Abstract: The present disclosure provides nucleic acid guided genome modifier chimeric or fusion proteins, complexes or conjugate thereof, having enhanced homology-directed repair (HDR). The nucleic acid guided genome modifier disclosed herein comprise the following two components (a) at least one defective CRISPR-Cas protein (CRISPR-dCas) devoid of a nucleolytic activity or any variant or mutant thereof; and (b) at least one nucleic acid modifier component; and at least one of: (c) at least one donor attachment domain (DAD) for binding at least one Donor nucleic acid molecule; and (d) at least one repair factor recruitment domain (RFRD). The present disclosure further provides nucleic acid sequences encoding the nucleic acid guided genome modifier disclosed herein, as well as systems thereof and therapeutic and non-therapeutic methods thereof.

Abstract: The present disclosure provides a display substrate and a display panel. The display substrate comprises: a base substrate, a first electrode layer, a first light-emitting layer, a first common connection layer, a second light-emitting layer, a third light-emitting layer, and a second electrode layer. The first electrode layer is provided on a side of the base substrate; the first light-emitting layer is provided on a side of the first electrode layer away from the base substrate; the first common connection layer is provided on a side of the first light-emitting layer away from the first electrode layer, and comprises a plurality of first sub-common connection layers; each second sub-light-emitting layer of the second light-emitting layer is provided on a side of each first sub-common connection layer away from the first light-emitting layer in one-to-one correspondence.

Abstract: This disclosure describes chimeric antigen receptors for expression in a Natural Killer (NK) cell, pharmaceutical compositions that include NK cells (and/or iPSCs) modified to express a chimeric antigen receptor, and methods involving such chimeric antigen receptors. Generally, the chimeric antigen receptor includes an ectodomain that includes an antigen recognition region, a transmembrane domain linked to the ectodomain, and an endodomain linked to the transmembrane domain. The endodomain can include a signaling peptide that activates an NK cell.

Abstract: Disclosed herein are systems and methods for generating and presenting virtual audio for mixed reality systems. A method may include determining a collision between a first object and a second object, wherein the first object comprises a first virtual object. A memory storing one or more audio models can be accessed. It can be determined if the one or more audio models stored in the memory comprises an audio model corresponding to the first object. In accordance with a determination that the one or more audio models comprises an audio model corresponding to the first object, an audio signal can be synthesized, wherein the audio signal is based on the collision and the audio model corresponding to the first object, and the audio signal can be presented to a user via a speaker of a head-wearable device.

Abstract: A corpus of textual data is generated with a machine-learned text generation model. The corpus of textual data includes a plurality of sentences. Each sentence is descriptive of a type of audio. For each of a plurality of audio recordings, the audio recording is processed with a machine-learned audio classification model to obtain training data including the audio recording and one or more sentences of the plurality of sentences closest to the audio recording within a joint audio-text embedding space of the machine-learned audio classification model. The sentence(s) are processed with a machine-learned generation model to obtain an intermediate representation of the one or more sentences. The intermediate representation is processed with a machine-learned cascaded diffusion model to obtain audio data. The machine-learned cascaded diffusion model is trained based on a difference between the audio data and the audio recording.

Abstract: A thermoformable spinal brace for customizable shaping to a wearer by a skilled clinician, preferably worn under the wearer's clothes and worn over and releasably attached to a subsystem of neuromotor training garments for the torso. The subsystem of garments for the torso may include upper- and lower-torso garments whether unitary or two or more pieces interconnected with flexible straps. An anterior apron assembly with strapping is included for further support, creating a unique therapeutic mammalian musculoskeletal spinal orthosis system.

Abstract: A system and method for monitoring and controlling an energy demand by an HVAC system utilizes a control device that is operably installed in the HVAC system. The system performs the following steps: receiving, in a control device, values of one or more parameters related to performance of the plurality of powered components; comparing the received values with corresponding predetermined threshold values; determining overloading of the electrical grid by a powered component based on respective values of one or more parameters being less than the corresponding predetermined threshold values for the powered component; and selectively controlling the operation of the powered component without disrupting operation of the remaining plurality of powered components.

Abstract: A thermoformable spinal brace for customizable shaping to a wearer by a skilled clinician, preferably worn under the wearer's clothes and worn over and releasably attached to a subsystem of neuromotor training garments for the torso. The subsystem of garments for the torso may include upper- and lower-torso garments whether unitary or two or more pieces interconnected with flexible straps. An anterior apron assembly with strapping is included for further support, creating a unique therapeutic mammalian musculoskeletal spinal orthosis system.

Abstract: A sequence online analytical processing (S-OLAP) system 50 for analysing an event database (41) storing events (12), the system (50) comprising: an S-OLAP engine (53) to compute an S-cuboid (49) for a query on the event database (41); a sequence query engine (54) to form part of the S-cuboid (49) by performing the steps of: selection, clustering, sequence formation and sequence grouping; a cuboid repository (52) to store computed S-cuboids (49) and to be searched by the S-OLAP engine (53) for an S-cuboid query to determine whether an S-cuboid has previously been computed; and a sequence cache (56) to cache constructed sequence groups.

Abstract: According to one embodiment of the invention, a network element synchronizes a number of clocks within the system while supporting multiple independent timing domains. The network element includes a local clock, which is free-running and is not necessarily synchronized with an external reference, that synchronously provides a local time value to the slave and master interfaces of each timing domain. Each slave interface of each timing domain independently determines timing information based on a received master clock synchronization event and the value of the local time when that synchronization event was received. The timing information is distributed to the master interfaces of the appropriate timing domain, and each master interface calculates an adjusted synchronization event based on the received timing information and the value of the local time when that timing information was received. The adjusted synchronization events are transmitted out of the network element to an external slave interface.

Abstract: A sequence online analytical processing (S-OLAP) system 50 for analysing an event database (41) storing events (12), the system (50) comprising: an S-OLAP engine (53) to compute an S-cuboid (49) for a query on the event database (41); a sequence query engine (54) to form part of the S-cuboid (49) by performing the steps of: selection, clustering, sequence formation and sequence grouping; a cuboid repository (52) to store computed S-cuboids (49) and to be searched by the S-OLAP engine (53) for an S-cuboid query to determine whether an S-cuboid has previously been computed; and a sequence cache (56) to cache constructed sequence groups.

Abstract: According to one embodiment of the invention, a network element synchronizes a number of clocks within the system while supporting multiple independent timing domains. The network element includes a local clock, which is free-running and is not necessarily synchronized with an external reference, that synchronously provides a local time value to the slave and master interfaces of each timing domain. Each slave interface of each timing domain independently determines timing information based on a received master clock synchronization event and the value of the local time when that synchronization event was received. The timing information is distributed to the master interfaces of the appropriate timing domain, and each master interface calculates an adjusted synchronization event based on the received timing information and the value of the local time when that timing information was received. The adjusted synchronization events are transmitted out of the network element to an external slave interface.

Abstract: A method and apparatus for a hot swappable media interface card capable of layer-1 processing is described. The media interface card transmits and receives physical layer network traffic with a main board. The main board performs media access control layer transformation.

Abstract: According to one embodiment of the invention, an apparatus used for collecting fluids during a medical procedure includes a fluid collection pouch having an open end, an inflatable bladder substantially surrounding a perimeter of the open end, and a pump coupled to the inflatable bladder. The pump is operable to inflate the inflatable bladder. According to another embodiment of the invention, an apparatus used for collecting fluids during a medical procedure includes a fluid collection pouch having an open end with a perimeter, a channel surrounding approximately one half of the perimeter of the open end, an inflatable bladder disposed within the channel, and a pump disposed within the channel and coupled to the inflatable bladder. The pump is operable to inflate the inflatable bladder.

Abstract: The wellbore pump of the present invention comprises a plunger having passage means which may be open or closed by a valve operated by a piston which is biased in the open position by a spring of selected strength such that the wellbore pressure may overcome the spring to close the valve when the accumulated hydrostatic pressure reaches a certain value. When the valve closes the reservoir pressure forces the plunger to the surface and causes the accumulated liquids to be pumped out of the wellbore. A stem extending from the top of the piston engages a top plate and causes the valve to open when the plunger reaches the top of the wellbore. Means is provided whereby the valve opens when it reaches the top of the wellbore and a latch may be provided to retain the plunger from returning to the bottom of the well.

Abstract: A mobile communication device (200) has a software architecture (302) that includes a closed operating environment (306). The closed operating environment is inaccessible to the user of the mobile communication device, and it includes software for implementing a reporting function designed to collect certain information from within the mobile communication device, and to transmit it to an entity outside the mobile communication device, such as a server (310).

Abstract: The wellbore pump of the present invention comprises a plunger having passage means which may be open or closed by a valve operated by a piston which is biased in the open position by a spring of selected strength such that the wellbore pressure may overcome the spring to close the valve when the accumulated hydrostatic pressure reaches a certain value. When the valve closes the reservoir pressure forces the plunger to the surface and causes the accumulated liquids to be pumped out of the wellbore. A stem extending from the top of the piston engages a top plate and causes the valve to open when the plunger reaches the top of the wellbore. Means is provided whereby the valve opens when it reaches the top of the wellbore and a latch may be provided to retain the plunger from returning to the bottom of the well.

Abstract: The wellbore pump of the present invention comprises a plunger having passage means which may be open or closed by a valve operated by a piston which is biased in the open position by a spring of selected strength such that the wellbore pressure may overcome the spring to close the valve when the accumulated hydrostatic pressure reaches a certain value. When the valve closes the reservoir pressure forces the plunger to the surface and causes the accumulated liquids to be pumped out of the wellbore. A stem extending from the top of the piston engages a top plate and causes the valve to open when the plunger reaches the top of the wellbore. Means is provided whereby the valve opens when it reaches the top of the wellbore and a latch may be provided to retain the plunger from returning to the bottom of the well.