Abstract: The technology relates to devices and methods thereof for the detection of one or more biomarkers from a user's exhaled breath. In one embodiment, the present invention provides a device comprising a metered dose inhaler, and a sensor that detects one or more biomarkers comprising HFA, CO2, and NO. In another embodiment, the device detects HFA, CO2 and NO simultaneously by photoacoustic spectroscopy. In another embodiment, the device may be used as part of an overall treatment regimen for asthma or COPD.

Abstract: The technology relates to devices and methods thereof for the detection of one or more biomarkers from a user's exhaled breath. In one embodiment, the present invention provides a device comprising a metered dose inhaler, and a sensor that detects one or more biomarkers comprising HFA, CO2, and NO. In another embodiment, the device detects HFA, CO2 and NO simultaneously by photoacoustic spectroscopy. In another embodiment, the device may be used as part of an overall treatment regimen for asthma or COPD.

Abstract: The present invention relates to simple and integrated devices for assessing lung health. In one embodiment, an all-in-one device that is able to measure lung function, ventilation, inflammation and breath identification of aerosol propellant for monitoring asthma inhaler effectiveness and compliance. In another embodiment, the device uses a gas sensor composed of a sintered metal oxide and/or solid electrolyte that detects HFA-134a through a change in electrical conductivity or a change in voltage when gases are adsorbed on the sensor's surface.

Abstract: The invention relates to measuring the effectiveness and an compliance of inhaler medication, such as for asthma treatment. In one embodiment, the invention provides a method of determining the effectiveness of an inhaler medication, comprising taking a measurement of HFA-134(a) from an exhaled breath of an individual after the individual has inhaled a medication, and determining an effective administration of the medication based on the presence of a high level of HFA-134(a).

Abstract: Disclosed herein are devices comprising a solid state gas sensor comprising a catalyst and a detection component capable of sensing halogenated gases through an increase or decrease in electrical conductivity. Further disclosed herein are methods of detecting one or more halogenated organic compounds, comprising providing a device comprising a solid state gas sensor comprising a catalyst and a detection component capable of sensing halogenated gases through an increase or decrease in electrical conductivity, and using the device to detect one or more small solid state halogenated organic compounds. Also disclosed herein are various methods of treating asthma in an individual.

Abstract: The invention relates to measuring the effectiveness and an compliance of inhaler medication, such as for asthma treatment. In one embodiment, the invention provides a method of determining the effectiveness of an inhaler medication, comprising taking a measurement of HFA-134(a) from an exhaled breath of an individual after the individual has inhaled a medication, and determining an effective administration of the medication based on the presence of a high level of HFA-134(a).

Abstract: A bioreactor for sampling the headspace above cells includes a glass reactor vessel having an interior space and a plurality of valves operatively coupled to the interior space of the glass reactor vessel. The bioreactor includes a sample holder configured to reside in the interior space. The interior space includes a charge of air with a known composition of volatile organic gases and, in some instances, doped with carbon dioxide. The sample holder may hold cells, bacteria, or viruses. The headspace may be sampled after incubation to determine the VOC content or content of specific VOC constituents. Examples include acetaldehyde and hexanaldehyde.

Abstract: A bioreactor for sampling the headspace above cells includes a glass reactor vessel having an interior space and a plurality of valves operatively coupled to the interior space of the glass reactor vessel. The bioreactor includes a sample holder configured to reside in the interior space. The interior space includes a charge of air with a known composition of volatile organic gases and, in some instances, doped with carbon dioxide. The sample holder may hold cells, bacteria, or viruses. The headspace may be sampled after incubation to determine the VOC content or content of specific VOC constituents. Examples include acetaldehyde and hexanaldehyde.