Patents by Inventor Dan M. Granoff

Dan M. Granoff has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Vaccines for broad spectrum protection against
    Patent number: 8980285
    Abstract: The present invention generally provides methods and vaccines for the prevention of diseases caused by Neisseria meningitidis bacteria, particularly serogroup B strains.
    Type: Grant
    Filed: March 15, 2005
    Date of Patent: March 17, 2015
    Assignee: Children's Hospital & Research Center At Oakland
    Inventors: Dan M. Granoff, Gregory R. Moe
  • GNA1870-based vesicle vaccines for broad spectrum protection against diseases caused by
    Patent number: 8968748
    Abstract: The present invention generally provides methods and compositions for eliciting an immune response against Neisseria spp. bacteria in a subject, particularly against a Neisseria meningitidis serogroup B strain.
    Type: Grant
    Filed: October 21, 2011
    Date of Patent: March 3, 2015
    Assignee: Children's Hospital & Research Center Oakland
    Inventors: Dan M. Granoff, Victor Chen-Hsi Hou
  • Ex-vivo passive protection bacteremia assay
    Patent number: 8663940
    Abstract: The present disclosure provides methods for assessing bactericidal antibodies in a biological sample by use of human fresh whole blood from a non-immune human as a reaction medium for the assay.
    Type: Grant
    Filed: December 10, 2009
    Date of Patent: March 4, 2014
    Assignee: Children's Hospital & Research Center Oakland
    Inventors: Dan M. Granoff, Jo Anne Welsch, Joyce Plested
  • Complement factor H-based assays for serum bactericidal activity against
    Patent number: 8476032
    Abstract: Assays for detection of bactericidal anti-Neisserial antibodies using a factor H polypeptide having a human amino acid sequence that mediates binding to Neisserial factor H binding protein (fHBp) are provided, as well as non-human animal models of Neisserial infection.
    Type: Grant
    Filed: August 26, 2009
    Date of Patent: July 2, 2013
    Assignees: Children's Hospital & Research Center Oakland, Novartis Vaccines and Diagnostics, SRL, The University of Massachusetts
    Inventors: Dan M. Granoff, JoAnne Welsch, Sanjay Ram
  • Peptides presenting an epitope of a domain of factor H binding protein and methods of use
    Patent number: 8470340
    Abstract: Polypeptides that can elicit antibodies that are bactericidal for different fHbp variant strains of N. meningitidis, and methods of use, are provided.
    Type: Grant
    Filed: September 2, 2009
    Date of Patent: June 25, 2013
    Assignees: Children's Hospital & Research Center Oakland, Novartis Vaccines and Diagnostics, SRL, Universita degli Studi del Molise
    Inventors: Peter Beernink, Franco Felici, Dan M. Granoff
  • Factor H Binding Proteins (FHBP) with Altered Properties and Methods of Use Thereof
    Publication number: 20120288517
    Abstract: Factor H binding proteins that can elicit antibodies that are bactericidal for at least one strain of N. meningitidis, and methods of use of such proteins, are provided.
    Type: Application
    Filed: May 9, 2012
    Publication date: November 15, 2012
    Inventors: Peter T. Beernink, Dan M. Granoff, Rolando Pajon Feyt
  • CHIMERIC FACTOR H BINDING PROTEINS (FHBP) AND METHODS OF USE
    Publication number: 20120121637
    Abstract: Chimeric fHbps that can elicit antibodies that are bactericidal for different fHbp variant strains of N. meningitidis, and methods of use, are provided.
    Type: Application
    Filed: April 29, 2010
    Publication date: May 17, 2012
    Inventors: Dan M. Granoff, Peter Beernink
  • Chimeric Factor H Binding Proteins (fHBP) Containing a Heterologous B Domain and Methods of Use
    Publication number: 20120107339
    Abstract: Chimeric fHBPs that can elicit antibodies that are bactericidal for different fHBP variant strains of N. meningitidis, and methods of use, are provided.
    Type: Application
    Filed: March 9, 2009
    Publication date: May 3, 2012
    Inventors: Dan M. Granoff, Peter Beernink, Jo Anne Welsch
  • GNA1870-Based Vesicle Vaccines for Broad Spectrum Protection Against Diseases Caused by Neisseria Meningitidis
    Publication number: 20120093867
    Abstract: The present invention generally provides methods and compositions for eliciting an immune response against Neisseria spp. bacteria in a subject, particularly against a Neisseria meningitidis serogroup B strain.
    Type: Application
    Filed: October 21, 2011
    Publication date: April 19, 2012
    Inventors: DAN M. GRANOFF, Victor Chen-Hsi Hou
  • Peptides Presenting an Epitope of a Domain of Factor H Binding Protein and Methods of Use
    Publication number: 20110318378
    Abstract: Polypeptides that can elicit antibodies that are bactericidal for different fHbp variant strains of N. meningitidis, and methods of use, are provided.
    Type: Application
    Filed: September 2, 2009
    Publication date: December 29, 2011
    Inventors: Peter Beernink, Franco Felici, Dan M. Granoff
  • Ex-Vivo Passive Protection Bacteremia Assay
    Publication number: 20110312020
    Abstract: The present disclosure provides methods for assessing bactericidal antibodies in a biological sample by use of human fresh whole blood from a non-immune human as a reaction medium for the assay.
    Type: Application
    Filed: December 10, 2009
    Publication date: December 22, 2011
    Inventors: Dan M. Granoff, Jo Anne Welsch, Joyce Plested
  • Factor H Binding Proteins (FHBP) with Altered Properties and Methods of Use Thereof
    Publication number: 20110256180
    Abstract: Factor H binding proteins that can elicit antibodies that are bactericidal for at least one strain of N. meningitidis, and methods of use of such proteins, are provided.
    Type: Application
    Filed: March 29, 2011
    Publication date: October 20, 2011
    Inventors: PETER T. BEERNINK, DAN M. GRANOFF, ROLANDO PAJON FEYT
  • Combination B/C vaccines
    Patent number: 8007815
    Abstract: Combination vaccines for treating or preventing Neisseria meningitidis infection are described. The vaccines include Neisseria meningitidis serogroup B proteoliposomic vesicles and Neissera meningitidis serogroup C conjugated oligosaccharides.
    Type: Grant
    Filed: May 28, 1999
    Date of Patent: August 30, 2011
    Assignees: Novartis AG, Statens Institutt for Folkehelse
    Inventors: Dan M. Granoff, Howard Raff, Ingeborg S. Aaberge, Bjorn Haneberg, Johan Holst
  • COMPLEMENT FACTOR H-BASED ASSAYS FOR SERUM BACTERICIDAL ACTIVITY AGAINST NEISSERIA MENINGITIDIS
    Publication number: 20100240075
    Abstract: Assays for detection of bactericidal anti-Neisserial antibodies using a factor H polypeptide having a human amino acid sequence that mediates binding to Neisserial factor H binding protein (fHBp) are provided, as well as non-human animal models of Neisserial infection.
    Type: Application
    Filed: August 26, 2009
    Publication date: September 23, 2010
    Inventors: Dan M. Granoff, JoAnne Welsch, Sanjay Ram
  • POLYSACCHARIDE DERIVATIVES AND USES IN INDUCTION OF AN IMMUNE RESPONSE
    Publication number: 20100068728
    Abstract: The present invention generally provides compositions comprising a polysaccharide derivative, and methods of their preparation and use for the prevention or treatment of diseases caused by Neisseria meningitidis bacteria, particularly group B (NmB) strains, and by E. coli K1. The invention provides a de-N-acetylated PS derivative in which one or more residues of the PS has been modified by de-N-acetylation. The invention also includes derivatives in which one or more of the N-acetyl groups of PS containing de-N-acetylated PS are replaced with other N-acyl groups, usually a lower acyl group of C2-C3. Further, the invention includes de-N-acetylated PS derivatives containing long chain hydrocarbons, as well as conjugates in which the de-N-acetylated PS derivative is linked to a carrier, e.g., a carrier protein.
    Type: Application
    Filed: August 12, 2009
    Publication date: March 18, 2010
    Inventors: Gregory R. Moe, Dan M. Granoff
  • Polysaccharide derivatives and uses in induction of an immune response
    Patent number: 7595307
    Abstract: The present invention generally provides compositions comprising a polysaccharide derivative, and methods of their preparation and use for the prevention or treatment of diseases caused by Neisseria meningitidis bacteria, particularly group B (NmB) strains, and by E. coli K1. The invention provides a de-N-acetylated PS derivative in which one or more residues of the PS has been modified by de-N-acetylation. The invention also includes derivatives in which one or more of the N-acetyl groups of PS containing de-N-acetylated PS are replaced with other N-acyl groups, usually a lower acyl group of C2-C3. Further, the invention includes de-N-acetylated PS derivatives containing long chain hydrocarbons, as well as conjugates in which the de-N-acetylated PS derivative is linked to a carrier, e.g., a carrier protein.
    Type: Grant
    Filed: June 23, 2005
    Date of Patent: September 29, 2009
    Assignee: Children's Hospital and Research Center at Oakland
    Inventors: Gregory R. Moe, Dan M. Granoff
  • Molecular mimetics of meningococcal B epitopes which elicit functionally active antibodies
    Patent number: 7534444
    Abstract: Molecular mimetics of a surface-exposed epitope on loop 4 of PorA of Neisseria meningitidis serogroup B (MenB) P1.2 serosubtype and antibodies produced against the same are disclosed. Compositions containing such molecular mimetics or the antibodies thereto can be used to prevent MenB disease, as well as for diagnosis of MenB infection.
    Type: Grant
    Filed: April 11, 2002
    Date of Patent: May 19, 2009
    Assignee: Novattis Vaccines and Diagnostics, Inc.
    Inventors: Dan M. Granoff, Gregory Moe, Rino Rappuoli
  • Methods for isolating molecular mimetics of unique serogroup B epitopes
    Patent number: 7504254
    Abstract: Novel bactericidal antibodies against Neisseria meningitidis serogroup B (“MenB”) are disclosed. The antibodies either do not cross-react or minimally cross-react with host tissue polysialic acid and hence pose minimal risk of autoimmune activity. The antibodies are used to identify molecular mimetics of unique epitopes found on MenB or E. coli K1. Examples of such peptide mimetics are described that elicit serum antibody capable of activating complement-mediated bacteriolysis of MenB. Vaccine compositions containing such mimetics can be used to prevent MenB or E. coli K1 disease without the risk of evoking autoantibody.
    Type: Grant
    Filed: October 5, 2005
    Date of Patent: March 17, 2009
    Assignee: Novartis Vaccines and Diagnostics, Inc.
    Inventors: Dan M. Granoff, Gregory R. Moe
  • Gna1870-Based Vesicle Vaccines for Broad Spectrum Protection Against Diseases Caused by Neisseria Meningitidis
    Publication number: 20080248065
    Abstract: The present invention generally provides methods and compositions for eliciting an immune response against Neisseria spp. bacteria in a subject, particularly against a Neisseria meningitidis serogroup B strain.
    Type: Application
    Filed: January 23, 2006
    Publication date: October 9, 2008
    Inventors: Dan M. Granoff, Victor Chen-Hsi
  • Methods for isolating molecular mimetics of unique serogroup B epitopes
    Patent number: 7063949
    Abstract: Novel bactericidal antibodies against Neisseria meningitidis serogroup B (“MenB”) are disclosed. The antibodies either do not cross-react or minimally cross-react with host tissue polysialic acid and hence pose minimal risk of autoimmune activity. The antibodies are used to identify molecular mimetics of unique epitopes found on MenB or E. coli K1. Examples of such peptide mimetics are described that elicit serum antibody capable of activating complement-mediated bacteriolysis of MenB. Vaccine compositions containing such mimetics can be used to prevent MenB or E. coli K1 disease without the risk of evoking autoantibody.
    Type: Grant
    Filed: August 19, 2003
    Date of Patent: June 20, 2006
    Assignees: Chiron Corporation, Children's Hospital Medical Center of Northern California
    Inventors: Dan M. Granoff, Gregory R. Moe