Patents by Inventor Dan Mitchell

Dan Mitchell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods for the identification of inhibitors of protein synthesis
    Patent number: 8431341
    Abstract: Compositions and methods for identifying inhibitors of RNA-target molecule interactions are provided as well as identifying inhibitors that block the role of tRNA in protein synthesis. The methods involve forming a mixture comprising a tRNA fragment molecule containing a modified nucleotide, a target molecule capable of binding to the tRNA fragment, and a test compound. The mixture is incubated under conditions that allow binding of the tRNA and the target molecule in the absence of the test compound. Assays can then be performed that detect whether or not the test compound inhibits the binding of the tRNA molecule and the target molecule. High throughput assays are also provided.
    Type: Grant
    Filed: June 28, 2010
    Date of Patent: April 30, 2013
    Assignee: Trana Discovery, Inc.
    Inventors: Richard H. Guenther, Winnell H. Newman, Samuel P. Yenne, Dan Mitchell, Andrzej Malkiewicz
  • Compositions and methods for the identification of inhibitors of protein synthesis
    Patent number: 8232378
    Abstract: Compositions and methods for identifying inhibitors of RNA-target molecule interactions are provided as well as identifying inhibitors that block the role of tRNA in protein synthesis. The methods involve forming a mixture comprising a tRNA fragment molecule containing a modified nucleotide, a target molecule capable of binding to the tRNA fragment, and a test compound. The mixture is incubated under conditions that allow binding of the tRNA and the target molecule in the absence of the test compound. Assays can then be performed that detect whether or not the test compound inhibits the binding of the tRNA molecule and the target molecule. High throughput assays are also provided.
    Type: Grant
    Filed: August 24, 2009
    Date of Patent: July 31, 2012
    Assignee: Trana Discovery, Inc.
    Inventors: Richard H. Guenther, Winnell H. Newman, Samuel P. Yenne, Dan Mitchell, Andrzej Malkiewicz
  • COMPOSITIONS AND METHODS FOR THE IDENTIFICATION OF INHIBITORS OF PROTEIN SYNTHESIS
    Publication number: 20110306509
    Abstract: Compositions and methods for identifying inhibitors of RNA-target molecule interactions are provided as well as identifying inhibitors that block the role of tRNA in protein synthesis. The methods involve forming a mixture comprising a tRNA fragment molecule containing a modified nucleotide, a target molecule capable of binding to the tRNA fragment, and a test compound. The mixture is incubated under conditions that allow binding of the tRNA and the target molecule in the absence of the test compound. Assays can then be performed that detect whether or not the test compound inhibits the binding of the tRNA molecule and the target molecule. High throughput assays are also provided.
    Type: Application
    Filed: June 28, 2010
    Publication date: December 15, 2011
    Inventors: Richard H. Guenther, Winnell H. Newman, Samuel P. Yenne, Dan Mitchell, Andrzej Malkiewicz
  • COMPOSITIONS AND METHODS FOR THE IDENTIFICATION OF INHIBITORS OF PROTEIN SYNTHESIS
    Publication number: 20100069260
    Abstract: Compositions and methods for identifying inhibitors of RNA-target molecule interactions are provided as well as identifying inhibitors that block the role of tRNA in protein synthesis. The methods involve forming a mixture comprising a tRNA fragment molecule containing a modified nucleotide, a target molecule capable of binding to the tRNA fragment, and a test compound. The mixture is incubated under conditions that allow binding of the tRNA and the target molecule in the absence of the test compound. Assays can then be performed that detect whether or not the test compound inhibits the binding of the tRNA molecule and the target molecule. High throughput assays are also provided.
    Type: Application
    Filed: August 24, 2009
    Publication date: March 18, 2010
    Inventors: Richard H. Guenther, Winnell H. Newman, Samuel P. Yenne, Dan Mitchell, Andrzej Malkiewicz
  • Compositions and methods for the identification of inhibitors of protein synthesis
    Patent number: 7598040
    Abstract: Compositions and methods for identifying inhibitors of RNA-target molecule interactions are provided as well as identifying inhibitors that block the role of tRNA in protein synthesis. The methods involve forming a mixture comprising a tRNA fragment molecule containing a modified nucleotide, a target molecule capable of binding to the tRNA fragment, and a test compound. The mixture is incubated under conditions that allow binding of the tRNA and the target molecule in the absence of the test compound. Assays can then be performed that detect whether or not the test compound inhibits the binding of the tRNA molecule and the target molecule. High throughput assays are also provided.
    Type: Grant
    Filed: November 21, 2007
    Date of Patent: October 6, 2009
    Assignee: Trana Discovery, Inc.
    Inventors: Richard H. Guenther, Winnell H. Newman, Samuel P. Yenne, Dan Mitchell, Andrzej Malkiewicz
  • COMPOSITIONS AND METHODS FOR THE IDENTIFICATION OF INHIBITORS OF PROTEIN SYNTHESIS
    Publication number: 20080199870
    Abstract: Compositions and methods for identifying inhibitors of RNA-target molecule interactions are provided as well as identifying inhibitors that block the role of tRNA in protein synthesis. The methods involve forming a mixture comprising a tRNA fragment molecule containing a modified nucleotide, a target molecule capable of binding to the tRNA fragment, and a test compound. The mixture is incubated under conditions that allow binding of the tRNA and the target molecule in the absence of the test compound. Assays can then be performed that detect whether or not the test compound inhibits the binding of the tRNA molecule and the target molecule. High throughput assays are also provided.
    Type: Application
    Filed: November 21, 2007
    Publication date: August 21, 2008
    Inventors: Richard H. GUENTHER, Winnell H. Newman, Samuel P. Yenne, Dan Mitchell, Andrzej Malkiewicz
  • Charcoal tray and grate lift system for gas barbecue grills
    Publication number: 20040112226
    Abstract: A gas barbecue grill including a firebox assembly containing a gas burner element, a cooking grate supported thereabove, a top casting rotatably affixed thereto, the firebox assembly defining a receiving slot in a sidewall thereof, and a tray carrier assembly configured to be slidably received within the receiving slot of the firebox assembly, the tray carrier assembly being configured to support a charcoal tray. The gas barbecue grill further includes a grate frame configured to support the cooking grate, and a grate lift assembly configured to raise and lower the grate frame relative to the firebox assembly.
    Type: Application
    Filed: November 7, 2003
    Publication date: June 17, 2004
    Inventors: Robert Johnston, Alex T. Gafford, Dan Mitchell, Sam Zaidspiner, Joseph Hale Andrews