Patents by Inventor Dan Mosoiu
Dan Mosoiu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7892849Abstract: A test strip having a small sample-receiving chamber on the order of less than 1 microliter. The inventive test strip includes a reagent layer that extends across the width of the test strip and also extends to the sample-receiving end, such that the edges of the reagent layer are aligned with the side and dose receiving edges of the test strip. The hydrophilic reagent extending to the dosing edge of the strip promotes wicking of the sample into the test strip. The end and side edges of the reagent layer are preferably formed as part of a cutting process that forms individual test strips from a larger web, which results in a smooth and thin reagent layer with a uniform thickness, substantially covering the entire floor of the sample-receiving chamber. The inventive mass production process helps improve the reproducibility of the quantity, location, thickness and other properties of the reagent layer, which in turn improves the accuracy of the test result.Type: GrantFiled: February 20, 2009Date of Patent: February 22, 2011Assignees: Roche Diagnostics Operations, Inc., Roche Operations Ltd.Inventors: David W. Burke, Michael Marquant, Udo Zapf, Michael Fritz, Dan Mosoiu, Chris Wilsey
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Patent number: 7879618Abstract: The present invention concerns a reagent coating mass which can be used in slot-die-coating of flat support materials in the manufacturing processes of test strips. Advantageously, the reagent mass of the invention exhibits certain superior rheological properties such as viscosity, surface tension and thixotropy. The reagent mass is preferably used to coat thin, narrow and homogeneous stripes of reagent material onto flat web material.Type: GrantFiled: January 29, 2009Date of Patent: February 1, 2011Assignees: Roche Diagnostics Operations, Inc., Roche Operations Ltd.Inventors: Dan Mosoiu, Christopher D. Wilsey
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Patent number: 7749437Abstract: The present invention concerns a reagent coating mass which can be used in slot-die-coating of flat support materials in the manufacturing processes of test strips. Advantageously, the reagent mass of the invention exhibits certain superior rheological properties such as viscosity, surface tension and thixotropy. The reagent mass is preferably used to coat thin, narrow and homogeneous stripes of reagent material onto flat web material.Type: GrantFiled: June 18, 2004Date of Patent: July 6, 2010Assignees: Roche Diagnostics Operations, Inc., Roche Operations, Ltd.Inventors: Dan Mosoiu, Christopher D. Wilsey
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Patent number: 7727467Abstract: A test strip having a small sample-receiving chamber on the order of less than 1 microliter. The inventive test strip includes a reagent layer that extends across the width of the test strip and also extends to the sample-receiving end, such that the edges of the reagent layer are aligned with the side and dose receiving edges of the test strip. The hydrophilic reagent extending to the dosing edge of the strip promotes wicking of the sample into the test strip. The end and side edges of the reagent layer are preferably formed as part of a cutting process that forms individual test strips from a larger web, which results in a smooth and thin reagent layer with a uniform thickness, substantially covering the entire floor of the sample-receiving chamber. The inventive mass production process helps improve the reproducibility of the quantity, location, thickness and other properties of the reagent layer, which in turn improves the accuracy of the test result.Type: GrantFiled: June 18, 2004Date of Patent: June 1, 2010Assignees: Roche Diagnostics Operations, Inc., Roche Operations, Ltd.Inventors: David W. Burke, Michael Marquant, Udo Zapf, Michael Fritz, Dan Mosoiu, Chris Wilsey
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Patent number: 7629175Abstract: The invention concerns test elements and methods for the optical detection of an analyte in a sample. The test element includes a support having at least one transparent portion, and a one-layer film positioned on the support. The film has a thickness when dry of less than about 10 ?m. The method includes contacting the sample with the test element and determining the analyte concentration in the sample.Type: GrantFiled: February 18, 2005Date of Patent: December 8, 2009Assignee: Roche Diagnostics Operations, Inc.Inventors: Wolfgang-Reinhold Knappe, Franz Wittmann, Dan Mosoiu, Carina Horn, Joachim Hoenes
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Publication number: 20090162532Abstract: The present invention concerns a reagent coating mass which can be used in slot-die-coating of flat support materials in the manufacturing processes of test strips. Advantageously, the reagent mass of the invention exhibits certain superior rheological properties such as viscosity, surface tension and thixotropy. The reagent mass is preferably used to coat thin, narrow and homogeneous stripes of reagent material onto flat web material.Type: ApplicationFiled: January 29, 2009Publication date: June 25, 2009Inventors: Dan Mosoiu, Christopher D. Wilsey
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Publication number: 20090151864Abstract: A test strip having a small sample-receiving chamber on the order of less than 1 microliter. The inventive test strip includes a reagent layer that extends across the width of the test strip and also extends to the sample-receiving end, such that the edges of the reagent layer are aligned with the side and dose receiving edges of the test strip. The hydrophilic reagent extending to the dosing edge of the strip promotes wicking of the sample into the test strip. The end and side edges of the reagent layer are preferably formed as part of a cutting process that forms individual test strips from a larger web, which results in a smooth and thin reagent layer with a uniform thickness, substantially covering the entire floor of the sample-receiving chamber. The inventive mass production process helps improve the reproducibility of the quantity, location, thickness and other properties of the reagent layer, which in turn improves the accuracy of the test result.Type: ApplicationFiled: February 20, 2009Publication date: June 18, 2009Inventors: David W. Burke, Michael Marquant, Udo Zapf, Michael Fritz, Dan Mosoiu, Chris Wilsey
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Publication number: 20060003397Abstract: The invention concerns test elements and methods for the optical detection of an analyte in a sample. The test element includes a support having at least one transparent portion, and a one-layer film positioned on the support. The film has a thickness when dry of less than about 10 ?m. The method includes contacting the sample with the test element and determining the analyte concentration in the sample.Type: ApplicationFiled: February 18, 2005Publication date: January 5, 2006Inventors: Wolfgang-Reinhold Knappe, Franz Wittmann, Dan Mosoiu, Carina Horn, Joachim Hoenes
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Publication number: 20050016844Abstract: A test strip having a small sample-receiving chamber on the order of less than 1 microliter. The inventive test strip includes a reagent layer that extends across the width of the test strip and also extends to the sample-receiving end, such that the edges of the reagent layer are aligned with the side and dose receiving edges of the test strip. The hydrophilic reagent extending to the dosing edge of the strip promotes wicking of the sample into the test strip. The end and side edges of the reagent layer are preferably formed as part of a cutting process that forms individual test strips from a larger web, which results in a smooth and thin reagent layer with a uniform thickness, substantially covering the entire floor of the sample-receiving chamber. The inventive mass production process helps improve the reproducibility of the quantity, location, thickness and other properties of the reagent layer, which in turn improves the accuracy of the test result.Type: ApplicationFiled: June 18, 2004Publication date: January 27, 2005Inventors: David Burke, Michael Marquant, Udo Zapf, Michael Fritz, Dan Mosoiu, Chris Wilsey
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Publication number: 20050008537Abstract: The present invention concerns a reagent coating mass which can be used in slot-die-coating of flat support materials in the manufacturing processes of test strips. Advantageously, the reagent mass of the invention exhibits certain superior rheological properties such as viscosity, surface tension and thixotropy. The reagent mass is preferably used to coat thin, narrow and homogeneous stripes of reagent material onto flat web material.Type: ApplicationFiled: June 18, 2004Publication date: January 13, 2005Inventors: Dan Mosoiu, Christopher Wilsey
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Patent number: 6455001Abstract: A skeleton-free functional layer of high precision which contains a wetting agent of formula I, II and/or III R1—CO—N(R2)—CH2—COOMe (I) R1—CO—N(R2)—CH2—CH2—SO3Me (II) HO2C—CH2—CH2—CH(NH—COR1)—CO2Me (III) in which R1 is a long-chained aliphatic residue, R2 is an alkyl residue with 1 to 8 C atoms and Me represents hydrogen or a metal atom, a diagnostic test strip having this functional layer as well as processes for the production of these objects are described.Type: GrantFiled: October 22, 1999Date of Patent: September 24, 2002Assignee: Roche Diagnostics GmbHInventors: Wolfgang-Reinhold Knappe, Dan Mosoiu
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Patent number: 5302346Abstract: A test carrier for the determination of ions containing a test layer which has a liquid-resistant, organic phase which contains a hydrophobic polymer in a homogeneous mixture with a hydrophobic, organic liquid of low volatility and an ionophore, as well as a substance which changes its colour in the presence of the ion to be determined. The test carrier is characterized in that the test layer contains particles with an oil number of 80-200 and the ionophore is homogeneously dispersed in the hydrophobic, organic phase. A second test layer contains a buffer capable of maintaining the pH therein at a value of between 5-10.Type: GrantFiled: March 8, 1993Date of Patent: April 12, 1994Assignee: Boehringer Mannheim GmbHInventors: Peter Vogel, Detlef Thym, Michael Fritz, Dan Mosoiu
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Patent number: 5290515Abstract: Method for the manufacture of a self-supporting test field material of very small layer thickness. In a strip of test material (1) comprising an open-pored fibre structure a reagent film mass (6) is embedded from an application side (1a) in such a way that it extensively penetrates into the pores of the carrier material. The reagent film mass (6) is smoothed on the opposite side (1b) by the relative motion of the ribbon and a smoothing tool (4) in such a way that the pores of the composite fibre structure are spanned by the reagent film mass (6). Finally, the carrier material ribbon (10) thus produced is dried essentially free of contact.Type: GrantFiled: October 20, 1992Date of Patent: March 1, 1994Assignee: Boehringer Mannheim GmbHInventors: Winfried Plesch, Dan Mosoiu, Hans Gotschel
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Patent number: 5211914Abstract: The invention concerns a test carrier for the determination of ions containing a test layer which has a liquid-resistant, organic phase which contains a hydrophobic polymer in a homogeneous mixture with a hydrophobic, organic liquid of low volatility and an ionophore, as well as a substance which changes its colour in the presence of the ion to be determined. The test carrier is characterized in that the test layer contains particles with an oil number of 80-200 and the ionophore is homogeneously dispersed in the hydrophobic, organic phase.Type: GrantFiled: May 10, 1991Date of Patent: May 18, 1993Assignee: Boehringer Mannheim GmbHInventors: Peter Vogel, Detlef Thym, Michael Fritz, Dan Mosoiu