Abstract: A drug delivery device for administration to a subject may include a reservoir containing an active pharmaceutical ingredient and a potential energy source. The drug delivery device may also include a trigger operatively associated with the potential energy source. The trigger may be configured to actuate at a predetermined location within the subject to deploy a jet of the active pharmaceutical ingredient into a tissue of an adjacent portion of the gastrointestinal tract. In some instances, the jet may be deployed into tissue of the stomach and/or small intestine of the subject. Further, in some embodiments, the operating parameters of the jet may be selected such that the jet penetrates the tissue of the gastrointestinal tract to form a depot of the active pharmaceutical ingredient disposed within the tissue.

Abstract: The present invention provides a drug delivery device (1) comprising: a drug reservoir (20) comprising a reservoir body (21) extending along a reference axis and an elastomeric stopper (30) arranged in the reservoir body (21), the elastomeric stopper (30) comprising a stopper body (31) extending between a front stopper end (32) and a rear stopper end (34) and having a plurality of axially spaced apart circumferential ribs (33) for sealing interaction with an interior wall (22) of the reservoir body (21), and a plunger rod structure (10) for displacing the elastomeric stopper (30) relative to the interior wall (22), the plunger rod structure (10) extending along the reference axis and comprising a distal end face (12, 14) adapted to interface with the rear stopper end (34).

Abstract: A drug delivery device (100) for estimating the amount of free air in a cartridge (1) comprising a cartridge receiving portion (not shown) adapted to receive a cartridge (1), the cartridge (1) comprising a body portion (6), an axially displaceable piston (5), and a distal outlet portion (4), an expelling assembly comprising an axially displaceable piston drive member (10) adapted to interface with the proximal piston (5) portion of a received cartridge (1), the piston drive member (10) is adapted to be moveable in a distal direction, and to thereby pressurize the drug in a received cartridge. The drug delivery device further comprises means for measuring and acquiring a property relating to a fluid pres-sure of the drug in a received cartridge (1), and where the property depends on the amount of free air (7) contained in the cartridge (1).

Abstract: The present invention relates to a device for storage and administration of a medicament suspension comprising a container (1) for receiving a medicament suspension wherein the container has two mixing elements (5, 6) which differ with respect to their density such that the first mixing element (5) has a density significantly above the background liquid and significantly above the fully mixed suspension density and the second mixing element (6) has a density significantly below the background liquid and significantly below the fully mixed suspension density.