Patents by Inventor Dan Peer

Dan Peer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Lipid particles for nucleic acid delivery and clinical applications of same
    Patent number: 12616662
    Abstract: Lipid particles for nucleic acid delivery and clinical applications of same are provided. Accordingly there is provided a lipid particle comprising a cationic lipid encapsulating a nucleic acid sequence, wherein said nucleic acid sequence encodes a protein having a length of at least 500 amino acids, the cationic lipid being represented by Formula I, as defined in the specification.
    Type: Grant
    Filed: November 17, 2022
    Date of Patent: May 5, 2026
    Assignee: Ramot at Tel-Aviv University Ltd.
    Inventors: Dan Peer, Daniel Rosenblum, Anna Gutkin
  • CANNABINOID ACID ESTER COMPOSITIONS AND USES THEREOF
    Publication number: 20260027079
    Abstract: The present disclosure provides pharmaceutical compositions including a cannabinoid acid ester compound alone or in combination with one or more additional cannabinoid compounds. In some embodiments, the cannabinoid acid ester compound is a cannabidiolic acid ester. A variety of therapeutic applications in which the cannabinoid acid ester compounds and pharmaceutical compositions find use are also provided, including combination therapies using cannabinoid acid ester compounds and one or more additional therapeutic agents.
    Type: Application
    Filed: July 31, 2025
    Publication date: January 29, 2026
    Inventors: Dror Robinson, Dan Peer, Joseph Tam, Raphael Mechoulam
  • Omentum based scaffold and delivery system
    Patent number: 12514957
    Abstract: Compositions of matter comprising decellularized omentum are disclosed. The compositions may be scaffolds, hydrogels or hydrogel precursor compositions. Methods of generating the compositions are disclosed as well as uses thereof.
    Type: Grant
    Filed: November 17, 2019
    Date of Patent: January 6, 2026
    Assignee: Ramot at Tel-Aviv University Ltd.
    Inventors: Tal Dvir, Dan Peer, Michal Shevach, Neta Soffer Tsur
  • Cannabinoid acid ester compositions and uses thereof
    Patent number: 12403114
    Abstract: The present disclosure provides pharmaceutical compositions including a cannabinoid acid ester compound alone or in combination with one or more additional cannabinoid compounds. In some embodiments, the cannabinoid acid ester compound is a cannabidiolic acid ester. A variety of therapeutic applications in which the cannabinoid acid ester compounds and pharmaceutical compositions find use are also provided, including combination therapies using cannabinoid acid ester compounds and one or more additional therapeutic agents.
    Type: Grant
    Filed: March 12, 2020
    Date of Patent: September 2, 2025
    Assignees: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD
    Inventors: Dror Robinson, Dan Peer, Joseph Tam, Raphael Mechoulam
  • CATIONIC LIPIDS FOR NUCLEIC ACID DELIVERY AND PREPARATION THEREOF
    Publication number: 20250162978
    Abstract: The present invention provides cationic lipids and lipid nanoparticle formulations comprising these lipids, alone or in combination with other lipids. These lipid nanoparticles may be formulated with nucleic acids to facilitate their intracellular delivery both in vitro and for therapeutic applications. The present invention also provides methods of chemical synthesis of these lipids, lipid nanoparticle preparation and formulation with nucleic acids.
    Type: Application
    Filed: October 21, 2024
    Publication date: May 22, 2025
    Inventors: Dan PEER, Srinivas RAMISHETTI
  • Method for treatment of a leukocyte related disease by delivery of nucleic acid molecules to leukocytes using targeted lipid particles
    Patent number: 12065664
    Abstract: Disclosed are targeted lipid based particles for delivery of nucleic acid molecules (such as siRNA) to leukocytes (such as T-Cells and B-cells). Further disclosed are uses of the targeted lipid based particles for treating Leukocytes-associated diseases, such as, cancer.
    Type: Grant
    Filed: December 21, 2020
    Date of Patent: August 20, 2024
    Assignee: RAMOT AT TEL-AVIV UNIVERSITY LTD.
    Inventors: Dan Peer, Shiri Weinstein, Itai Antoine Toker, Srinivas Ramishetti
  • CATIONIC LIPIDS FOR NUCLEIC ACID DELIVERY AND PREPARATION THEREOF
    Publication number: 20240246898
    Abstract: The present invention provides cationic lipids and lipid nanoparticle formulations comprising these lipids, alone or in combination with other lipids. These lipid nanoparticles may be formulated with nucleic acids to facilitate their intracellular delivery both in vitro and for therapeutic applications. The present invention also provides methods of chemical synthesis of these lipids, lipid nanoparticle preparation and formulation with nucleic acids.
    Type: Application
    Filed: October 18, 2023
    Publication date: July 25, 2024
    Inventors: Dan PEER, Srinivas RAMISHETTI
  • LIPIDS SUITABLE FOR NUCLEIC ACID DELIVERY
    Publication number: 20240166593
    Abstract: The present invention provides lipids and lipid nanoparticle formulations comprising these lipids, alone or in combination with other lipids. These lipid nanoparticles may be formulated with nucleic acids to facilitate their intracellular delivery both in vitro and for therapeutic applications. The present invention also provides methods of chemical synthesis of these lipids, lipid nanoparticle preparation and formulation with nucleic acids.
    Type: Application
    Filed: February 2, 2022
    Publication date: May 23, 2024
    Inventors: Srinivas RAMISHETTI, Dan PEER
  • Cationic lipids for nucleic acid delivery and preparation thereof
    Patent number: 11851389
    Abstract: The present invention provides cationic lipids and lipid nanoparticle formulations comprising these lipids, alone or in combination with other lipids. These lipid nanoparticles may be formulated with nucleic acids to facilitate their intracellular delivery both in vitro and for therapeutic applications. The present invention also provides methods of chemical synthesis of these lipids, lipid nanoparticle preparation and formulation with nucleic acids.
    Type: Grant
    Filed: November 7, 2017
    Date of Patent: December 26, 2023
    Assignee: RAMOT AT TEL-AVIV UNIVERSITY LTD.
    Inventors: Dan Peer, Srinivas Ramishetti
  • MAdCAM-1 POLYPEPTIDES AND USES THEREOF
    Publication number: 20230357353
    Abstract: MAdCAM-1 polypeptides are provided. Accordingly there is provided a polypeptide comprising an amino acid sequence of MAdCAM-1 capable of binding alpha4beta7 integrin, wherein said polypeptide is in association with a therapeutic or a detectable moiety. Also provided are methods of treating and diagnosing inflammation mediated by MAdCAM-1.
    Type: Application
    Filed: November 17, 2022
    Publication date: November 9, 2023
    Applicant: Ramot at Tel-Aviv University Ltd.
    Inventors: Niels DAMMES, Dan PEER
  • MODULAR PLATFORM FOR TARGETED THERAPEUTICS
    Publication number: 20230312745
    Abstract: A lipidated secondary antibody is disclosed. Particles comprising same are also disclosed.
    Type: Application
    Filed: June 7, 2023
    Publication date: October 5, 2023
    Applicant: Ramot at Tel-Aviv University Ltd.
    Inventors: Ranit KEDMI, Nuphar VEIGA, Itai BENHAR, Dan PEER
  • Modular platform for targeted therapeutics
    Patent number: 11708421
    Abstract: A lipidated secondary antibody is disclosed. Particles comprising same are also disclosed.
    Type: Grant
    Filed: July 18, 2017
    Date of Patent: July 25, 2023
    Assignee: Ramot at Tel-Aviv University Ltd.
    Inventors: Ranit Kedmi, Nuphar Veiga, Itai Benhar, Dan Peer
  • LIPID PARTICLES FOR NUCLEIC ACID DELIVERY AND CLINICAL APPLICATIONS OF SAME
    Publication number: 20230201127
    Abstract: Lipid particles for nucleic acid delivery and clinical applications of same are provided. Accordingly there is provided a lipid particle comprising a cationic lipid encapsulating a nucleic acid sequence, wherein said nucleic acid sequence encodes a protein having a length of at least 500 amino acids, the cationic lipid being represented by Formula I, as defined in the specification.
    Type: Application
    Filed: November 17, 2022
    Publication date: June 29, 2023
    Applicant: Ramot at Tel-Aviv University Ltd.
    Inventors: Dan PEER, Daniel ROSENBLUM, Anna GUTKIN
  • Immunoparticles and methods of generating and using same
    Patent number: 11338042
    Abstract: A pharmaceutical composition comprising an immunoparticle is provided. The pharmaceutical composition comprising a monoclonal secondary antibody immunocomplexed with a primary antibody, wherein said monoclonal secondary antibody is coupled on an outer surface of a particle and wherein said particle is loaded with a pharmaceutical agent.
    Type: Grant
    Filed: December 3, 2019
    Date of Patent: May 24, 2022
    Assignee: Ramot at Tel-Aviv University Ltd.
    Inventors: Ranit Kedmi, Dan Peer
  • CANNABINOID ACID ESTER COMPOSITIONS AND USES THEREOF
    Publication number: 20220151972
    Abstract: The present disclosure provides pharmaceutical compositions including a cannabinoid acid ester compound alone or in combination with one or more additional cannabinoid compounds. In some embodiments, the cannabinoid acid ester compound is a cannabidiolic acid ester. A variety of therapeutic applications in which the cannabinoid acid ester compounds and pharmaceutical compositions find use are also provided, including combination therapies using cannabinoid acid ester compounds and one or more additional therapeutic agents.
    Type: Application
    Filed: March 12, 2020
    Publication date: May 19, 2022
    Inventors: Dror Robinson, Dan Peer, Joseph Tam, Raphael Mechoulam
  • TARGETED LIPID PARTICLES FOR SYSTEMIC DELIVERY OF NUCLEIC ACID MOLECULES TO LEUKOCYTES
    Publication number: 20210108228
    Abstract: Disclosed are targeted lipid based particles for delivery of nucleic acid molecules (such as siRNA) to leukocytes (such as T-Cells and B-cells). Further disclosed are uses of the targeted lipid based particles for treating Leukocytes-associated diseases, such as, cancer.
    Type: Application
    Filed: December 21, 2020
    Publication date: April 15, 2021
    Inventors: Dan PEER, Shiri WEINSTEIN, Itai Antoine TOKER, Srinivas RAMISHETTI
  • Targeted lipid particles for systemic delivery of nucleic acid molecules to leukocytes
    Patent number: 10920246
    Abstract: Disclosed are targeted lipid based particles for delivery of nucleic acid molecules (such as siRNA) to leukocytes (such as T-Cells and B-cells). Further disclosed are uses of the targeted lipid based particles for treating Leukocytes-associated diseases, such as, cancer.
    Type: Grant
    Filed: May 25, 2016
    Date of Patent: February 16, 2021
    Assignee: RAMOT AT TEL-AVIV UNIVERSITY LTD.
    Inventors: Dan Peer, Shiri Weinstein, Itai Antoine Toker, Srinivas Ramishetti
  • OMENTUM BASED SCAFFOLD AND DELIVERY SYSTEM
    Publication number: 20200101198
    Abstract: Compositions of matter comprising decellularized omentum are disclosed. The compositions may be scaffolds, hydrogels or hydrogel precursor compositions. Methods of generating the compositions are disclosed as well as uses thereof.
    Type: Application
    Filed: November 17, 2019
    Publication date: April 2, 2020
    Applicant: Ramot at Tel-Aviv University Ltd.
    Inventors: Tal DVIR, Dan PEER, Michal SHEVACH, Neta SOFFER TSUR
  • IMMUNOPARTICLES AND METHODS OF GENERATING AND USING SAME
    Publication number: 20200101170
    Abstract: A pharmaceutical composition comprising an immunoparticle is provided. The pharmaceutical composition comprising a monoclonal secondary antibody immunocomplexed with a primary antibody, wherein said monoclonal secondary antibody is coupled on an outer surface of a particle and wherein said particle is loaded with a pharmaceutical agent.
    Type: Application
    Filed: December 3, 2019
    Publication date: April 2, 2020
    Applicant: Ramot at Tel-Aviv University Ltd.
    Inventors: Ranit KEDMI, Dan PEER
  • Liposomal formulations for delivery of nucleic acids
    Patent number: 10583084
    Abstract: There are provided liposomes, comprising cationic lipids, a membrane stabilizing lipid and at least one lipid conjugated to a polyethylene glycol (PEG) derivative, in particular PEG-amine, the liposomes are coated with a glycosaminoglycan, in particular, Hyaluronic Acid (HA), compositions comprising the same, methods for their preparation and uses thereof for the efficient delivery of nucleic acids, such as, si RNA molecules and for treating various conditions, such as cancer.
    Type: Grant
    Filed: June 25, 2015
    Date of Patent: March 10, 2020
    Assignee: RAMOT AT TEL-AVIV UNIVERSITY LTD.
    Inventor: Dan Peer