Abstract: There is provided a method of re-classifying a clinically significant feature of a medical image as an artifact, comprising: feeding a target medical image captured by a specific medical imaging sensor at a specific setup into a machine learning model, obtaining a target feature map as an outcome of the machine learning model, wherein the target feature map includes target features classified as clinically significant, analyzing the target feature map with respect to sample feature map(s) obtained as an outcome of the machine learning model fed a sample medical image captured by at least one of: the same specific medical imaging sensor and the same specific setup, wherein the sample feature map(s) includes sample features classified as clinically significant, identifying target feature(s) depicted in the target feature map having attributes matching sample feature(s) depicted in the sample feature map(s), and re-classifying the identified target feature(s) as an artifact.