Patents by Inventor Dan R. Littman

Dan R. Littman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DNA encoding the T cell surface protein T4 and use of fragments of T4 in the treatment of AIDS
    Patent number: 5871913
    Abstract: A single-stranded nucleic acid molecule which encodes the amino acid sequence comprising at least a portion of a T4 glycoprotein is provided. Additionally, amino acid sequences which comprise at least a portion of a T4 glycoprotein and are useful as a prophylaxis for treating a subject with acquired immune deficiency syndrome are provided. These amino acid sequences, which are capable of specifically forming a complex with a human immunodeficiency virus glycoprotein and which are soluble in an aqueous solution may be administered to a subject infected with a human immunodeficiency virus so as to block the human immunodeficiency virus from binding to T4 cells. Monoclonal antibodies directed to the water-soluble amino acid sequences of the present invention may be used as vaccines for immunizing a subject against acquired immune deficiency syndrome.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: February 16, 1999
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Paul J. Maddon, Dan R. Littman, Leonard Chess, Richard Axel, Robin Weiss, J. Steven McDougal
  • Soluble forms of the T cell surface protein CD4
    Patent number: 5126433
    Abstract: A single-stranded nucleic acid molecule which encodes an amino acid sequence comprising at least a portion of a T4 glycoprotein is provided. Additionally, amino acid sequences which comprise at least a portion of a T4 glycoprotein and are useful as a prophylaxis for treating a subject with acquired immune deficiency syndrome are provided. These amino acid sequences, are capable of specifically forming a complex with a human immunodeficiency virus envelope glycoprotein and which are soluble in an aqueous solution. Monoclonal antibodies directed to the water-soluble amino acid sequences of the present invention may be used as vaccines for immunizing a subject against acquired immune deficiency syndrome.
    Type: Grant
    Filed: October 23, 1987
    Date of Patent: June 30, 1992
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Paul J. Maddon, Leonard Chess, Richard Axel, Robin Weiss, Dan R. Littman, J. Steven McDougal