Abstract: The antibody-drug conjugates provided herein including embodiments thereof, include the compound triptolide attached to a cancer-specific antibody (e.g., cetuximab) and are, inter alia, useful as highly effective anti-cancer therapeutics. The conjugates provided herein are capable of targeting cancer cells and thereby specifically deliver triptolide to the cancer cell.

Abstract: A method comprising, in a cloud computing system: receiving a new job at the cloud computing system; sampling VMs (Virtual Machines) of the cloud computing system for the load currently handled by each of the VMs; if the load currently handled by the VMs is within operational bounds, sending the new job to one of the VMs which currently handles the highest load compared to other ones of the VMs; and if the load currently handled by the VMs is beyond operational bounds, sending the new job to one of the VMs which currently handles the lowest load compared to other ones of the VMs.

Abstract: Systems and methods for locating network errors. The system includes a plurality of host nodes in a network of host nodes and intermediary nodes, and a database storing route data for each of a plurality of host node pairs. The system includes a controller configured to identify a subject intermediary node to investigate for network errors and select, using route data stored in the database, a set of target probe paths. Each target probe path includes a respective pair of host nodes separated by a network path including at least one target intermediary node, which is either the subject intermediary node or an intermediary node that is a next-hop neighbor of the subject intermediary node. The controller is configured to test each target probe path in the set of target probe paths and to determine, based on a result of the testing, an operational status of the subject intermediary node.

Abstract: Systems and methods are provided for allocating resources of a network among a plurality of traffic demands to optimize fairness and network utilization. Methods based on flow-increase dynamics converge toward an upward max-min fair (UMMF) allocation, in which the value of each traffic demand cannot be increased, along any of its paths, even if larger traffic demands are removed from the network. An efficient iterative algorithm that converges to a UMMF solution is also provided. The described methods and systems can be implemented efficiently, distributively, and asynchronously.

Abstract: Systems and methods are provided for allocating resources of a network among a plurality of traffic demands to optimize fairness and network utilization. Methods based on flow-increase dynamics converge toward an upward max-min fair (UMMF) allocation, in which the value of each traffic demand cannot be increased, along any of its paths, even if larger traffic demands are removed from the network. An efficient iterative algorithm that converges to a UMMF solution is also provided. The described methods and systems can be implemented efficiently, distributively, and asynchronously.

Abstract: Systems and methods for fault detection in large scale networks are provided. Probing instructions are generated by a probing controller associated with a network having a plurality of nodes. The probing instructions include a specified source node and a specified destination node. Each probing instruction is transmitted to a probing agent coupled to the specified source node and a data packet is transmitted from the probing agent to the specified destination node. A fault detection module is informed of probing instructions associated with failed transmissions, identifies a plurality of nodes having a likelihood of being in a network path associated with failed transmissions, and processes the plurality of nodes having a likelihood of being in the network paths associated with failed transmissions to identify of a set of likely failed nodes.

Abstract: A drill bit is disclosed that in one embodiment includes a pad configured to extend and retract from a surface of the drill bit, a motor, a linearly movable member coupled to the motor, a hydraulic unit configured to apply force on the pad, and wherein motion of the motor in a first direction causes the linearly movable member in a first direction to cause the hydraulic unit to exert a force on the pad to extend the pad.

Abstract: A method comprising, in a cloud computing system: receiving a new job at the cloud computing system; sampling VMs (Virtual Machines) of the cloud computing system for the load currently handled by each of the VMs; if the load currently handled by the VMs is within operational bounds, sending the new job to one of the VMs which currently handles the highest load compared to other ones of the VMs; and if the load currently handled by the VMs is beyond operational bounds, sending the new job to one of the VMs which currently handles the lowest load compared to other ones of the VMs.

Abstract: A solar thermal energy system (20) includes a plurality of modules (22), which are connected end-to-end to define an extended solar trough. Each module includes a frame, having an outer edge of circular profile and an inner edge of parabolic profile, having a focus at a geometrical center of the circular profile. The frame includes first and second end segments (42) at respective first and second ends of the module, and a pair of rigid torque tubes (44) connected longitudinally between the first and second end segments. A motorized drive (46) engages and rotates the outer edge of the frame about the geometrical center. Multiple mirror segments (40) are fitted to the inner edge of the frame. At least one heat transfer tube segment (24) is held stationary at the geometrical center of the frame.

Abstract: A drill bit and method of drilling a wellbore. The drill bit includes a pad configured to extend and retract from a surface of the drill bit, and a force application device configured to extend and retract the pad. The force application device includes a screw driven by an electric motor that linearly moves a drive unit to extend and retract the pad from the drill bit surface. The drill bit may be conveyed by a drill string and the pad may be extended from the drill bit face to drill the wellbore.

Abstract: In one aspect, a drill bit is disclosed that in one embodiment includes a pad configured to extend and retract from a surface of the drill bit and a force application device configured to extend and retract the pad, wherein the force application device includes a force action member that includes a lever action device configured to extend and retract the pad from the drill bit surface. In another aspect, a method of drilling a wellbore is provided that in one embodiment includes: conveying a drill string having a drill bit at an end thereof, wherein the drill bit includes a pad configured to extend and retract from a surface of the drill bit and a force application device that includes a lever action device configured to extend and retract the pad from the surface of the drill bit; and rotating the drill bit to drill the wellbore.

Abstract: Systems and methods for splitting a network traffic flow in a data network are described. A flow of traffic between a source node and a destination node in the data network is split into a set of data paths. A data path includes one or more data links between nodes in the data network. A submap of the data network that excludes at least one data link is used to determine the set of flow paths.

Abstract: A method for erecting a solar field includes inserting piles into the ground in a predefined pattern covering an area of the solar field, and deploying rails between the piles. Elements of an array of solar collectors are transported along the rails to respective deployment locations in the solar field. The solar collectors are erected on the piles using the elements at the respective deployment locations.

Abstract: A closure includes a panel closing against a frame. A set of abutment surfaces for supporting the panel against applied forces is completed by a displaceable abutment block which selectively assumes an engaged state disposed between an abutment surface of the panel and an abutment surface of a strike jamb. The geometry of engagement is such that forces acting on the abutment block opposing opening of the panel are primarily compressive forces. Certain implementations additionally, or alternatively, employ abutment blocks for locking along the lintel or the threshold of the opening.

Abstract: A closure includes a panel closing against a frame. A set of abutment surfaces for supporting the panel against applied forces is completed by a displaceable abutment block which selectively assumes an engaged state disposed between an abutment surface of the panel and an abutment surface of a strike jamb. The geometry of engagement is such that forces acting on the abutment block opposing opening of the panel are primarily compressive forces. Certain implementations additionally, or alternatively, employ abutment blocks for locking along the lintel or the threshold of the opening.

Abstract: In one aspect, a drill bit is disclosed that in one embodiment includes a pad configured to extend and retract from a surface of the drill bit and a force application device configured to extend and retract the pad, wherein the force application device includes a force action member that includes a lever action device configured to extend and retract the pad from the drill bit surface. In another aspect, a method of drilling a wellbore is provided that in one embodiment includes: conveying a drill string having a drill bit at an end thereof, wherein the drill bit includes a pad configured to extend and retract from a surface of the drill bit and a force application device that includes a lever action device configured to extend and retract the pad from the surface of the drill bit; and rotating the drill bit to drill the wellbore.

Abstract: A drill bit is disclosed that in one embodiment includes a pad configured to extend and retract from a surface of the drill bit, a motor, a linearly movable member coupled to the motor, a hydraulic unit configured to apply force on the pad, and wherein motion of the motor in a first direction causes the linearly movable member in a first direction to cause the hydraulic unit to exert a force on the pad to extend the pad.

Abstract: In one aspect, a drill bit is disclosed that in one embodiment includes a pad configured to extend and retract from a surface of the drill bit, and a force application device configured to extend and retract the pad, wherein the force application device includes a screw driven by an electric motor that linearly moves a drive unit to extend and retract the pad from the drill bit surface. In another aspect, a method of drilling a wellbore is provided that in one embodiment includes: conveying a drill string having a drill bit at an end thereof, wherein the drill bit includes a pad configured to extend and retract from a surface of the drill bit and a force application device configured to extend and retract the pad, wherein the force application device includes a screw driven by an electric motor that moves a drive unit to extend the pad from the drill bit face; and rotating the drill bit to drill the wellbore.

Abstract: A seating system for supporting a user in a seated position employs a worn article (10), such as a tactical vest or a backpack, carried on the torso of the user (12). An anchoring system is deployed in defined spatial relation to a lower seat support (16). The anchoring system and the worn article have complementary connecting portions (20) selectively interconnectable to anchor the worn article (10) relative to the lower seat support (16) so that the lower seat support and the worn article together define a seat for supporting the user in a seated position with a region (14) of the worn article providing a back rest. The complementary connecting portions are disconnectable to allow the user to move freely with the worn article remaining on the torso of the user.

Abstract: Systems and methods are provided for allocating resources of a network among a plurality of traffic demands to optimize fairness and network utilization. Methods based on flow-increase dynamics converge toward an upward max-min fair (UMMF) allocation, in which the value of each traffic demand cannot be increased, along any of its paths, even if larger traffic demands are removed from the network. An efficient iterative algorithm that converges to a UMMF solution is also provided. The described methods and systems can be implemented efficiently, distributively, and asynchronously.