Patents by Inventor Dan Robin Müller

Dan Robin Müller has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for the Identification and Separation of Non-regulatory T-cells from a Mixture of Regulatory T-cells
    Publication number: 20110097313
    Abstract: The present invention relates to a method of identifying and separating non-regulatory T-cells (conventional T-cells) from a mixture comprising regulatory T-cells by using of the CD154 molecule (CD40 ligand) through depletion of CD154+ T-cells from the mixture or in combination with additional positive selection of Treg using markers that are specific for regulatory T-cells, such as for example, CD25, GITR, CTLA4 or markers which are specific for activated regulatory T-cells, such as, for example, CD137, “latent TGF-beta (LAP)”, GARP (LRRC32), CD121a/b, thereby generating a cell composition of activated Treg cells. The invention relates also to a kit comprising an antibody for detecting CD154 and at least one additional antibody for detecting markers for activated or non-activated regulatory T-cells. The antibodies can be coupled to a fluorescent dye or magnetic microparticles.
    Type: Application
    Filed: September 9, 2010
    Publication date: April 28, 2011
    Applicant: Miltenyi Biotec GmbH
    Inventors: Anne Schönbrunn, Dan Robin Müller, Siegfried Kohler, Marco Frentsch, Andreas Thiel