Abstract: Provided herein are compositions and methods for treating cancer. In particular, provided herein are compositions, methods, and uses of targeted therapy to treat cancer (e.g., prostate cancer) in subjects with CDK12 mutations.

Abstract: The present disclosure relates to methods of determining a treatment course of action. In particular, the present disclosure relates to mutations in the gene encoding estrogen receptor and their association with responsiveness to estrogen therapies for cancer.

Abstract: Methods, systems and computer program products provide for a Risk Assessment Engine that receives body ambient temperature data captured by a sensor in contact with a person. The Risk Assessment Engine characterizes types of activities performed by the person during a time range associated with the body ambient temperature data. The Risk Assessment Engine determines a risk classification individualized for the person based on respective workloads and the corresponding allocations of work and rest experienced by the person during performance of the characterized types of activities.

Abstract: Provided herein are compositions and methods for treating cancer. In particular, provided herein are compositions, methods, and uses of targeted therapy to treat cancer (e.g., prostate cancer) in subjects with CDK12 mutations.

Abstract: Methods, systems and computer program products provide for a Risk Assessment Engine that receives body ambient temperature data captured by a sensor in contact with a person. The Risk Assessment Engine characterizes types of activities performed by the person during a time range associated with the body ambient temperature data. The Risk Assessment Engine determines a risk classification individualized for the person based on respective workloads and the corresponding allocations of work and rest experienced by the person during performance of the characterized types of activities.

Abstract: The present disclosure relates to methods of determining a treatment course of action. In particular, the present disclosure relates to mutations in the gene encoding estrogen receptor and their association with responsiveness to estrogen therapies for cancer.

Abstract: The present disclosure relates to methods of determining a treatment course of action. In particular, the present disclosure relates to mutations in the gene encoding estrogen receptor and their association with responsiveness to estrogen therapies for cancer.

Abstract: The present disclosure relates to compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, the present disclosure relates to gene fusions as diagnostic markers and clinical targets for cancer.

Abstract: Provided herein are kits, compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, the present invention relates to recurrent gene fusions as diagnostic markers and clinical targets for hemangiopericytoma.

Abstract: The present disclosure relates to methods of determining a treatment course of action. In particular, the present disclosure relates to mutations in the gene encoding estrogen receptor and their association with responsiveness to estrogen therapies for cancer.

Abstract: The present disclosure relates to compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, the present disclosure relates to gene fusions as diagnostic markers and clinical targets for cancer.

Abstract: Provided herein are kits, compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, the present invention relates to recurrent gene fusions as diagnostic markers and clinical targets for hemangiopericytoma.

Abstract: Non-inclusive cache systems and methods are provided. In one embodiment a non-inclusive cache system is provided comprising a non-inclusive cache and a cache agent that receives a request for access to the non-inclusive cache and denies the request for access to the non-inclusive cache if the non-inclusive cache system exceeds a predetermined level of activity.

Abstract: An embodiment of a multiprocessor computer system comprises main memory, a remote processor capable of accessing the main memory, a remote cache device operative to store accesses by said remote processor to said main memory, and a filter tag cache device associated with the main memory. The filter cache device is operative to store information relating to remote ownership of data in the main memory including ownership by the remote processor. The filter cache device is operative to selectively invalidate filter tag cache entries when space is required in the filter tag cache device for new cache entries. The remote cache device is responsive to events indicating that a cache entry has low value to the remote processor to send a hint to the filter tag cache device. The filter tag cache device is responsive to a hint in selecting a filter tag cache entry to invalidate.

Abstract: The present disclosure relates to compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, the present disclosure relates to gene fusions as diagnostic markers and clinical targets for breast cancer.

Abstract: A molding apparatus is configured with article molding regions that receive a direct flow of a molding material feed such that external flow channels are not needed. The article molding regions are formed into front sides of opposed “A” and “B” surface mold tools that, when moved into a mating relationship with one another, form closed molding cavities within which molded articles are generated from molding material feed. The article molding regions each generally have a body bounded by a perimeter that establishes an outer edge for an article molded in the one of the closed molding cavities. With at least the “A” surface mold tool, a port is coupled with the body of each article molding region to establish a direct pathway is through which the molding material feed flows to enter the article molding regions, and thus the closed molding cavity, without having to flow along the tool front sides outside of the article molding regions.

Abstract: A molding apparatus is configured with a distribution channel configured to deliver a blended feed composition directly into an article molding region such that a molded article is formed with gating on the bottom surface of the article. The article molding regions are formed into front sides of opposed “A” and “B” surface mold tools that, when moved into a mating relationship with one another, form closed molding cavities within which molded articles are generated from molding material feed. The article molding regions each generally have a body bounded by a perimeter that establishes an outer edge for an article molded in the one of the closed molding cavities. Additionally, the body of each article molding region of the “A” surface mold tool is adapted for molding a bottom surface for the composite article, and the body of the article molding region of the “B” surface mold tool is adapted for molding a top surface for the composite article.

Abstract: A molding apparatus is configured with article molding regions that receive a direct flow of a molding material feed such that external flow channels are not needed. The article molding regions are formed into front sides of opposed “A” and “B” surface mold tools that, when moved into a mating relationship with one another, form closed molding cavities within which molded articles are generated from molding material feed. The article molding regions each generally have a body bounded by a perimeter that establishes an outer edge for an article molded in the one of the closed molding cavities. With at least the “A” surface mold tool, a port is coupled with the body of each article molding region to establish a direct pathway is through which the molding material feed flows to enter the article molding regions, and thus the closed molding cavity, without having to flow along the tool front sides outside of the article molding regions.

Abstract: In one embodiment, there are described a sectored cache system and method of operation. A cache data block comprises separately updatable cache sectors. A common tag block contains metadata for the cache sectors of the data block and is writable as a whole. A pending allocation table (PAT) contains data representing pending writes to the tag block. When writing changes data to the tag block, the changed data is broadcast to the PAT to update data representing other pending writes to the tag block so that when the other pending writes are written to the tag block changed data from received broadcasts is included.

Abstract: In one embodiment, a controller for an associative memory having n ways contains circuitry for sending a request to search an indexed location in each of the n ways for a tag, wherein the tag and an index that is used to denote the indexed location form a memory address. The controller also contains circuitry, responsive to the request, for sending a set of n validity values, each validity value indicating, for a respective way, whether the indexed location is a valid location or a defective location. Additionally, the controller contains circuitry for receiving a hit signal that indicates whether a match to the tag was found at any of the indexed locations, wherein no hit is ever received for a defective location.