Abstract: The present disclosure relates to an enhanced multi-dimensional chromatography system and method using selectable At-Column Dilution to improve compatibility of the interface and transfer between the multiple dimensions. The use of At-Column Dilution (“ACD”) with multi-dimensional chromatography can provide greater retention of the diverted components on subsequent stationary phases, and increase the sensitivity and peak shape of the component(s) separated on subsequent dimensions.

Abstract: Certain aspects of the present methods and systems may focus on computer implemented methods and systems for managing pseudonymous communication sessions. Such a system may include a data store, including data records corresponding to a plurality of available data communication addresses (“DCAs”), and including a first DCA; a CPU; and memory. The memory may include instructions for causing the CPU to execute a method including: obtaining a pseudonymous communication session (“PCS”) initiation request including a second DCA; removing the first data communication address from said plurality of available data communication addresses and associating the first DCA the second DCA in the data store; providing the first DCA in response to said pseudonymous communication session initiation request; and, in the event of obtaining a data communication from a source DCA directed to the first DCA, creating a PCS between the source DCA and the second DCA.

Abstract: The present disclosure relates to an enhanced multi-dimensional chromatography system and method using selectable At-Column Dilution to improve compatibility of the interface and transfer between the multiple dimensions. The use of At-Column Dilution (“ACD”) with multi-dimensional chromatography can provide greater retention of the diverted components on subsequent stationary phases, and increase the sensitivity and peak shape of the component(s) separated on subsequent dimensions.