Patents by Inventor Dan Shochat

Dan Shochat has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Radioprotectant for peptides labeled with radioisotope
    Patent number: 6338835
    Abstract: A method of ameliorating degradation radiolabeled peptides, especially radiolabeled proteins such as antibodies, by including povidone, also widely known as polyvinylpyrrolidone or PVP, as a radioprotectant in a composition containing a radiolabeled peptide is described. A radioprotectant composition and a stable peptide-radioisotope composition having povidone are also described. Ascorbic acid or other secondary stabilizers may also be added to the compositions to further enhance radioprotection.
    Type: Grant
    Filed: December 2, 1999
    Date of Patent: January 15, 2002
    Assignee: Coulter Pharmaceutical, Inc.
    Inventors: Dan Shochat, Albert S. K. Chan, Michael J. Buckley, David Colcher
  • Radioprotectant for peptides labeled with radioisotope
    Patent number: 5961955
    Abstract: A method of ameliorating degradation of radiolabeled peptides, especially radiolabeled proteins such as antibodies, by including povidone, also widely known as polyvinylpyrrolidone or PVP, as a radioprotectant in a composition containing a radiolabeled peptide is described. A radioprotectant composition and a stable peptide-radioisotope composition having povidone are also described. Ascorbic acid or other secondary stabilizers may also be added to the compositions to further enhance radioprotection.
    Type: Grant
    Filed: August 21, 1997
    Date of Patent: October 5, 1999
    Assignee: Coulter Pharmaceutical, Inc.
    Inventors: Dan Shochat, Albert S. K. Chan, Michael J. Buckley, David Colcher
  • Method for radiolabeling antibody fragments
    Patent number: 5514363
    Abstract: A protein containing at least one pendant sulfhydryl group is directly radiolabeled with a radiometal which binds tightly to sulfhydryl groups, using one or more pendant sulfhydryl groups on the protein as endogenous ligands and optionally using an exogenous ligand which binds tightly to the radiometal ion to further stabilize the chelate.
    Type: Grant
    Filed: January 7, 1993
    Date of Patent: May 7, 1996
    Assignee: Immunomedics, Inc.
    Inventors: Dan Shochat, Hans J. Hansen, Robert S. Wu
  • Method for radiolabeling proteins
    Patent number: 5061641
    Abstract: A protein containing at least one pendant sulfhydryl group is directly radiolabeled with a radiometal which binds tightly to sulfhydryl groups, using one or more pendant sulfhydral groups on the protein as endogenous ligands and optionally using an exogenous ligand which binds tightly to the radiometal ion to further stabilize the chelate.
    Type: Grant
    Filed: April 1, 1988
    Date of Patent: October 29, 1991
    Assignee: Immunomedics, Inc.
    Inventors: Dan Shochat, Hans J. Hansen, Robert S. Wu
  • Non-enzymatic immunohistochemical staining system and reagents
    Patent number: 4792521
    Abstract: A non-enzymatic method of immunohistochemical staining uses a bound electron transfer agent to achieve amplification of antibody binding to specific antigens of interest in a histology or cytology specimen. A preferred embodiment uses a bound phenazine, which is reduced with a soluble reducing agent, and which in turn reduces a tetrazolium salt, to precipitate a formazan dye at the site of primary antibody binding to the antigen of interest. Reagents and kits for use in the method are also provided.
    Type: Grant
    Filed: August 15, 1985
    Date of Patent: December 20, 1988
    Assignee: Immunomedics, Inc.
    Inventor: Dan Shochat
  • Method for producing a CSAp tryptic peptide and anti-CSAp antibodies
    Patent number: 4468457
    Abstract: A tryptic peptide is produced by partial tryptic digestion of purified, high molecular size colon-specific antigen-p (CSAp), to produce a lower molecular size antigen carrying the CSAp antigenic determinant. The tryptic peptide is used to produce monospecific anti-CSAp antibodies.
    Type: Grant
    Filed: June 1, 1981
    Date of Patent: August 28, 1984
    Assignee: David M. Goldenberg
    Inventors: Milton D. Goldenberg, Dan Shochat