Patents by Inventor Dan Simionescu
Dan Simionescu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11773362Abstract: Bioreactors and components of bioreactors are described as may be beneficially utilized in development and conditioning of cellular materials for study or implant. The bioreactors are modular, and components of the bioreactors can be easily assembled with alternatives provided to develop specific, predetermined conditioning environments for cellular materials (e.g., implantable tissue). By selection of one of multiple alternative compliance chambers, a bioreactor can be utilized to condition tissue in a low-pressure circuit (e.g., a pulmonary heart circuit), and by utilization of an alternative compliance chamber, the bioreactor can instead condition tissue in a high-pressure circuit (e.g., an aortic heart circuit).Type: GrantFiled: April 29, 2021Date of Patent: October 3, 2023Assignee: Clemson University Research FoundationInventors: Leslie Sierad, Christopher Delaney, Richard Pascal, III, Dan Simionescu, Agneta Simionescu
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Publication number: 20220073869Abstract: Embodiments of the present specification provide systems and methods for holding one or more tissues, such as veins, such that the tissue remains open in a chamber while undergoing orbital shaking with various solutions and to allow uniform treatment during a decellularization process. A frame is held on a stand to which the tissues are attached and comprises a tension inducing mechanism to cause the tissues to controllably stretch. The frame is removed from the stand, with the tissue attached to it, and placed in a decellularization chamber for uniform treatment of the tissue.Type: ApplicationFiled: September 3, 2021Publication date: March 10, 2022Inventors: Narendra R. Vyavahare, Teodor Dan Simionescu, Agnes Nagy-Mehesz, Ajay Houde
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Publication number: 20210246411Abstract: Bioreactors and components of bioreactors are described as may be beneficially utilized in development and conditioning of cellular materials for study or implant. The bioreactors are modular, and components of the bioreactors can be easily assembled with alternatives provided to develop specific, predetermined conditioning environments for cellular materials (e.g., implantable tissue). By selection of one of multiple alternative compliance chambers, a bioreactor can be utilized to condition tissue in a low-pressure circuit (e.g., a pulmonary heart circuit), and by utilization of an alternative compliance chamber, the bioreactor can instead condition tissue in a high-pressure circuit (e.g., an aortic heart circuit).Type: ApplicationFiled: April 29, 2021Publication date: August 12, 2021Inventors: LESLIE SIERAD, CHRISTOPHER DELANEY, RICHARD PASCAL, III, DAN SIMIONESCU, AGNETA SIMIONESCU
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Patent number: 11034928Abstract: Bioreactors and components of bioreactors are described as may be beneficially utilized in development and conditioning of cellular materials for study or implant. The bioreactors are modular and components of the bioreactors can be easily assembled with alternatives provided to develop specific, predetermined conditioning environments for cellular materials (e.g., implantable tissue). By selection of one of multiple alternative compliance chambers, a bioreactor can be utilized to condition tissue in a low pressure circuit (e.g., a pulmonary heart circuit), and by utilization of an alternative compliance chamber, the bioreactor can instead condition tissue in a high pressure circuit (e.g., an aortic heart circuit).Type: GrantFiled: July 23, 2015Date of Patent: June 15, 2021Assignee: Clemson University Research FoundationInventors: Leslie Sierad, Christopher Delaney, Richard Pascal, III, Dan Simionescu, Agneta Simionescu
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Patent number: 10987449Abstract: Systems and methods that establish a pressure differential across a tissue wall to encourage complete decellularization of the wall are described. The methods can be utilized for decellularization of blood vessel tissue including heart valves and surrounding tissues. The methods and systems can essentially completely decellularize the treated tissue segments. Systems can be utilized to decellularize one or multiple tissue segments at a single time.Type: GrantFiled: April 9, 2019Date of Patent: April 27, 2021Assignee: Clemson University Research FoundationInventors: Leslie Sierad, Eliza Laine Shaw, George Fercana, Dan Simionescu
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Publication number: 20200181558Abstract: Cell seeding devices and methods for utilization of the devices are described. The devices include a rolling needle support that carries a plurality of channeled needles thereon. Upon rolling the support over the surface of a scaffold, the needles penetrate the scaffold surface and deliver cells to the interior of the scaffold. The devices can deliver cells to a scaffold at a high density with high cellular retention and survival.Type: ApplicationFiled: October 31, 2019Publication date: June 11, 2020Inventors: Dan Simionescu, Benjamin Jesse Fisher, Harrison Smallwood
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Patent number: 10660754Abstract: Tissue holders that can be used for gripping natural or synthetic heart valves are described. The tissue holder can include a clamping mechanism and a spring and can be self-adjusting with regard to pressure applied to the tissue gripped in the holder. The tissue holder can be removably attached to systems for processing the tissues and can provide completely hands-free processing of a tissue from development or excisement to implantation and/or completion of testing.Type: GrantFiled: June 18, 2018Date of Patent: May 26, 2020Assignee: Clemson University Research FoundationInventors: Leslie Sierad, Richard Pascal, III, Chris deBorde, Dan Simionescu, Agneta Simionescu
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Publication number: 20190231930Abstract: Systems and methods that establish a pressure differential across a tissue wall to encourage complete decellularization of the wall are described. The methods can be utilized for decellularization of blood vessel tissue including heart valves and surrounding tissues. The methods and systems can essentially completely decellularize the treated tissue segments. Systems can be utilized to decellularize one or multiple tissue segments at a single time.Type: ApplicationFiled: April 9, 2019Publication date: August 1, 2019Inventors: LESLIE SIERAD, ELIZA LAINE SHAW, GEORGE FERCANA, DAN SIMIONESCU
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Patent number: 10293082Abstract: Systems and methods that establish a pressure differential across a tissue wall to encourage complete decellularization of the wall are described. The methods can be utilized for decellularization of blood vessel tissue including heart valves and surrounding tissues. The methods and systems can essentially completely decellularize the treated tissue segments. Systems can be utilized to decellularize one or multiple tissue segments at a single time.Type: GrantFiled: July 23, 2015Date of Patent: May 21, 2019Assignee: Clemson University Research FoundationInventors: Leslie Sierad, Eliza Laine Shaw, George Fercana, Dan Simionescu
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Publication number: 20180296342Abstract: Tissue holders that can be used for gripping natural or synthetic heart valves are described. The tissue holder can include a clamping mechanism and a spring and can be self-adjusting with regard to pressure applied to the tissue gripped in the holder. The tissue holder can be removably attached to systems for processing the tissues and can provide completely hands-free processing of a tissue from development or excisement to implantation and/or completion of testing.Type: ApplicationFiled: June 18, 2018Publication date: October 18, 2018Inventors: Leslie Sierad, Richard Pascal, III, Chris deBorde, Dan Simionescu, Agneta Simionescu
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Patent number: 10022225Abstract: Tissue holders that can be used for gripping natural or synthetic heart valves are described. The tissue holder can include a clamping mechanism and a spring and can be self-adjusting with regard to pressure applied to the tissue gripped in the holder. The tissue holder can be removably attached to systems for processing the tissues and can provide completely hands-free processing of a tissue from development or excisement to implantation and/or completion of testing.Type: GrantFiled: July 23, 2015Date of Patent: July 17, 2018Assignee: CLEMSON UNIVERSITY RESEARCH FOUNDATIONInventors: Leslie Sierad, Richard Pascal, Christopher deBorde, Dan Simionescu, Agneta Simionescu
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Publication number: 20160243282Abstract: A hydrogel biomaterial that can be utilized as a nucleus pulposus replacement material is described. The hydrogel biomaterial can is an elastin-glycosaminoglycan-collagen composite hydrogel biomaterial that can mimic the biochemical and functional characteristics of the human nucleus pulposus. Methods for forming the hydrogel biomaterial are also described as are methods for use of the hydrogel biomaterial, one of which is as an in vivo nucleus pulposus replacement material, another of which is a scaffolding material for use in nucleus pulposus tissue engineering applications.Type: ApplicationFiled: March 4, 2016Publication date: August 25, 2016Inventors: Dan Simionescu, Jeremy J. Mercuri
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Patent number: 9283301Abstract: A hydrogel biomaterial that can be utilized as a nucleus pulposus replacement material is described. The hydrogel biomaterial can is an elastin-glycosaminoglycan-collagen composite hydrogel biomaterial that can mimic the biochemical and functional characteristics of the human nucleus pulposus. Methods for forming the hydrogel biomaterial are also described as are methods for use of the hydrogel biomaterial, one of which is as an in vivo nucleus pulposus replacement material, another of which is a scaffolding material for use in nucleus pulposus tissue engineering applications.Type: GrantFiled: December 13, 2012Date of Patent: March 15, 2016Assignee: Clemson UniversityInventors: Dan Simionescu, Jeremy J. Mercuri
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Patent number: 9283241Abstract: Disclosed is a medical device treated with a phenolic compound and a process for treating a device with the phenolic compound. For example, a collagen or elastin-based scaffold can be treated with pentagalloyl glucose (PGG). The treated scaffold can become resistant to glycoxidative stress associated with advanced glycation end products (AGEs) that are present in a hyperglycemic environments associated with diabetes mellitus. The treated scaffold can exhibit a reduced increase in stiffness as compared to an untreated scaffold. The treated scaffold can also exhibit reduced inflammation without negatively affecting the ability of the scaffold to remodel in vivo.Type: GrantFiled: July 10, 2013Date of Patent: March 15, 2016Assignee: Clemson UniversityInventors: Agneta Simionescu, Dan Simionescu, James Chow
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Publication number: 20160022420Abstract: Tissue holders that can be used for gripping natural or synthetic heart valves are described. The tissue holder can include a clamping mechanism and a spring and can be self-adjusting with regard to pressure applied to the tissue gripped in the holder. The tissue holder can be removably attached to systems for processing the tissues and can provide completely hands-free processing of a tissue from development or excisement to implantation and/or completion of testing.Type: ApplicationFiled: July 23, 2015Publication date: January 28, 2016Inventors: Leslie Sierad, Richard Pascal, III, Christopher deBorde, Dan Simionescu, Agneta Simionescu
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Publication number: 20160022408Abstract: Systems and methods that establish a pressure differential across a tissue wail to encourage complete decellularization of the wall are described. The methods can be utilized for decellularization of blood vessel tissue including heart valves and surrounding tissues. The methods and systems can essentially completely decellularize the treated tissue segments. Systems can be utilized to decellularize one or multiple tissue segments at a single time.Type: ApplicationFiled: July 23, 2015Publication date: January 28, 2016Inventors: Leslie Sierad, Eliza Laine Shaw, George Fercana, Dan Simionescu
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Publication number: 20160024452Abstract: Bioreactors and components of bioreactors are described as may be beneficially utilized in development and conditioning of cellular materials for study or implant. The bioreactors are modular and components of the bioreactors can be easily assembled with alternatives provided to develop specific, predetermined conditioning environments for cellular materials (e.g., implantable tissue). By selection of one of multiple alternative compliance chambers, a bioreactor can be utilized to condition tissue in a low pressure circuit (e.g., a pulmonary heart circuit), and by utilization of an alternative compliance chamber, the bioreactor can instead condition tissue in a high pressure circuit (e.g., an aortic heart circuit).Type: ApplicationFiled: July 23, 2015Publication date: January 28, 2016Inventors: Leslie Sierad, Christopher Delaney, Richard Pascal, III, Dan Simionescu, Agneta Simionescu
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Patent number: 9005289Abstract: A nucleus pulposus replacement is described that includes a containment balloon that can sequester synthetic and/or tissue engineered fill material(s) in the nucleus pulposus region of the IVD thus mitigating migration and expulsion of the fill materials. The containment balloon can be formed of a biocompatible material that includes the structural proteins elastin and collagen. The containment balloon is joined to a closure device that can be used to deliver a fill material, e.g., a hydrogel, to the interior of the containment balloon following implantation of the replacement device in the intervertebral disc area.Type: GrantFiled: June 22, 2012Date of Patent: April 14, 2015Assignee: Clemson UniversityInventors: Dan Simionescu, Jeremy Mercuri
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Patent number: 8840150Abstract: A male fitting has a body that defines a fluid passage that extends through the body from a first end to a second end. The body may include a first portion adjacent to the first end, a second portion adjacent to the second end and a middle portion separating the first and second portions. The body may further define a slot between the middle portion and the second end. The slot extends at least partially circumferentially around the body. An actuating member may extend at least partially around the body. The actuating member may have at least one stop feature that engages with the body, and a retaining feature that is at least partially aligned with the slot. A spring disposed between the body and the actuating member may exert a force on the actuating member so as to position the retaining feature radially outward from the slot.Type: GrantFiled: June 25, 2013Date of Patent: September 23, 2014Inventors: Leslie Sierad, Samuel G. Rankin, Dan Simionescu
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Publication number: 20140018909Abstract: Disclosed is a medical device treated with a phenolic compound and a process for treating a device with the phenolic compound. For example, a collagen or elastin-based scaffold can be treated with pentagalloyl glucose (PGG). The treated scaffold can become resistant to glycoxidative stress associated with advanced glycation end products (AGEs) that are present in a hyperglycemic environments associated with diabetes mellitus. The treated scaffold can exhibit a reduced increase in stiffness as compared to an untreated scaffold. The treated scaffold can also exhibit reduced inflammation without negatively affecting the ability of the scaffold to remodel in vivo.Type: ApplicationFiled: July 10, 2013Publication date: January 16, 2014Inventors: Agneta Simionescu, Dan Simionescu, James Chow