Abstract: The present disclosure relates to recombinant binding proteins comprising a designed ankyrin repeat domain with binding specificity for fibroblast activation protein (FAP). In addition, the disclosure relates to nucleic acids encoding such binding proteins, pharmaceutical compositions comprising such binding proteins or nucleic acids, and the use of such binding proteins, nucleic acids or pharmaceutical compositions in methods for localizing or delivering a biologically active molecule in FAP-expressing tissue, such as tumor tissue, and for treating, diagnosing or imaging diseases, such as cancer, in a mammal, including a human.