Patents by Inventor Dan Tse

Dan Tse has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • A 5'-CAP ANALOG MODIFIED mRNA
    Publication number: 20250171513
    Abstract: The invention provides mRNAs modified with a series of novel 5?-cap analogs, wherein the 5?-cap analogs can improve transcription, mRNA stability, and mRNA translation efficiency and durability, and the mRNA modified with the 5?-cap analogs could inhibit tumor growth and improve survival significantly better than the control CleanCap modified-mRNA.
    Type: Application
    Filed: February 16, 2023
    Publication date: May 29, 2025
    Inventors: Dan Tse, Teodelinda Mirabella, Dehua Wang, Sheng Bi, Lakshmi Bhagat
  • A 5'-CAP ANALOG MODIFIED mRNA
    Publication number: 20240294592
    Abstract: The invention provides mRNAs modified with a series of novel 5?-cap analogs, wherein the 5?-cap analogs can improve transcription, mRNA stability, and mRNA translation efficiency and durability, and the mRNA modified with the 5?-cap analogs could inhibit tumor growth and improve survival significantly better than the control CleanCap modified-mRNA.
    Type: Application
    Filed: February 16, 2023
    Publication date: September 5, 2024
    Inventors: Dan Tse, Teodelinda Mirabella, Dehua Wang, Sheng Bi, Lakshmi Bhagat
  • Modification of gene transcription and translation efficiency by 5?UTR sequence variation
    Patent number: 11951120
    Abstract: This invention relates to the fields of mRNA vaccines, mRNA therapy, and gene therapy and specifically to the use of gene expression vectors or PCR amplicons containing various 5?UTR sequences followed by coding sequences for in vitro and in vivo production of mRNA or proteins of interest.
    Type: Grant
    Filed: December 7, 2022
    Date of Patent: April 9, 2024
    Inventors: Jaewoo Lee, Dehua Wang, Xiaoyao Hao, Yue Gao, Jie Liu, Shan He, Ting He, Dan Tse
  • Modification of Gene Transcription and Translation Efficiency by 5'UTR Sequence Variation
    Publication number: 20230310484
    Abstract: This invention relates to the fields of mRNA vaccines, mRNA therapy, and gene therapy and specifically to the use of gene expression vectors or PCR amplicons containing various 5?UTR sequences followed by coding sequences for in vitro and in vivo production of mRNA or proteins of interest.
    Type: Application
    Filed: December 7, 2022
    Publication date: October 5, 2023
    Inventors: Jaewoo Lee, Dehua Wang, Xiaoyao Hao, Yue Gao, Jie Liu, Shan He, Ting He, Dan Tse