Abstract: Disclosed are isolated single heavy chain variable (VHH) monoclonal antibodies, antigen binding fragments thereof, and bispecific antibodies include these VHH monoclonal antibodies, wherein the VHH monoclonal antibody or antigen binding fragment specifically binds a canine programmed death (PD)-1. Nucleic acid molecules encoding these VHH monoclonal antibodies and antigen binding fragments are also disclosed, as are expression vectors including these nucleic acid molecules and host cells including these expression vectors. Methods of detecting canine PD-1, and methods of increasing cytotoxic T cell activity and treating tumors are also disclosed.

Abstract: Disclosed are isolated single heavy chain variable (VHH) monoclonal antibodies, antigen binding fragments thereof, and bispecific antibodies include these VHH monoclonal antibodies, wherein the VHH monoclonal antibody or antigen binding fragment specifically binds a canine programmed death (PD)-1. Nucleic acid molecules encoding these VHH monoclonal antibodies and antigen binding fragments are also disclosed, as are expression vectors including these nucleic acid molecules and host cells including these expression vectors. Methods of detecting canine PD-1, and methods of increasing cytotoxic T cell activity and treating tumors are also disclosed.

Abstract: A lock for lavatory plumbing fixtures includes one or more griping members adapted to receive and attach to an internal rim of the lavatory fixture bowl. At least one of the gripping members can be translationally adapted or slideably engaged. A keyed rotational lock or a padlock can be incorporated for locking the article in place. Alternatively, a screw having a special head can be utilized to prevent unauthorized unlocking of the article.

Abstract: A lock for lavatory plumbing fixtures includes one or more griping members adapted to receive and attach to an internal rim of the lavatory fixture bowl. At least one of the gripping members can be translationally adapted or slideably engaged. A keyed rotational lock or a padlock can be incorporated for locking the article in place. Alternatively, a screw having a special head can be utilized to prevent unauthorized unlocking of the article.