Abstract: Technologies for customized drug provisioning include a drug dosage determination server and a drug dispenser device. The drug dosage determination server is configured to obtain patient physiological data associated with a patient, determine a drug dosage for the patient based on the patient physiological data, generate drug dosage instructions for a drug dispenser device, based on the determined drug dosage, and transmit the drug dosage instructions to the drug dispenser device. The drug dispenser device is configured to receive drug dosage instructions from the drug dosage determination server, prompt the patient for authentication credentials, determine whether the patient is authenticated, generate the drug based on the drug dosage instructions in response to a determination that the patient is authenticated, and dispense the drug. Other embodiments are described.