Patents by Inventor Dan Wilkinson

Dan Wilkinson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Device and method for intracellular delivery of biomolecular cargo via acoustic wave exposure
    Patent number: 11684922
    Abstract: A microfluidic-based device and system is disclosed for the high-throughput intracellular delivery of biomolecular cargo to cells (eukaryotic or prokaryotic) or enveloped viruses. Cargo integration occurs due to transient membrane permeabilization by exposure to bulk acoustic waves (BAWs) transduced from surface acoustic waves (SAWs) generated by a rapidly oscillating piezoelectric substrate. In this approach, temporary pores are established across the cellular membrane as cells are partially deformed and squeezed or subject to shearing forces as they travel through the vibrational modes created within the microfludic channel(s) of the device.
    Type: Grant
    Filed: February 13, 2018
    Date of Patent: June 27, 2023
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Paul S. Weiss, Steven J. Jonas, Dan Wilkinson, Adam Z. Stieg, Jason Belling
  • DEVICE AND METHOD FOR INTRACELLULAR DELIVERY OF BIOMOLECULAR CARGO VIA ACOUSTIC WAVE EXPOSURE
    Publication number: 20190381507
    Abstract: A microfluidic-based device and system is disclosed for the high-throughput intracellular delivery of biomolecular cargo to cells (eukaryotic or prokaryotic) or enveloped viruses. Cargo integration occurs due to transient membrane permeabilization by exposure to bulk acoustic waves (BAWs) transduced from surface acoustic waves (SAWs) generated by a rapidly oscillating piezoelectric substrate. In this approach, temporary pores are established across the cellular membrane as cells are partially deformed and squeezed or subject to shearing forces as they travel through the vibrational modes created within the microfludic channel(s) of the device.
    Type: Application
    Filed: February 13, 2018
    Publication date: December 19, 2019
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Paul S. Weiss, Steven J. Jonas, Dan Wilkinson, Adam Z. Stieg, Jason Belling