Patents by Inventor Dan Xia
Dan Xia has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20250332275Abstract: The disclosure provides a branched structure polypeptide peptide carrier and its variations. The branched structure peptide has the following sequence formula: The technical solution of the disclosure enables efficient delivery of nucleic acids to tissues and organs in vivo for targeted therapy. The polypeptides have several times more conformational flexibility and affinity than macromolecular drugs (proteins and antibodies). The branched structure polypeptides possess long-lasting in vivo stability while maintaining strong affinity and minimal toxicity. By forming stable nanocomplexes or nanoparticles through electrostatic interactions with nucleic acid molecules, they can facilitate the delivery of nucleic acid drugs and their stable release inside cells, thereby enhancing the activity of nucleic acid-based therapeutics.Type: ApplicationFiled: February 21, 2025Publication date: October 30, 2025Applicant: SUZHOU HEALIRNA BIOTECHNOLOGY CO., LTD.Inventors: Qingqing LU, Dan XIA, Cheng YI, Youzhen GE, Hongpeng HU, Jianhao JIANG, Tianyi ZHONG, Lixia ZHANG, Kan JIA, Yuyang ZHANG
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Publication number: 20240409586Abstract: The present invention relates to a novel cyclic peptide carrier in the field of pharmaceutical technology and its various forms, where the cyclic peptide has the general sequence formula P-(X)m-Cys-(Y)n-Cys-(Z)o-P. The invention also encompasses the construction and preparation technology of a composition or formulation formed by the novel cyclic peptide carrier carrying nucleic acids, drugs, or therapeutic agents. Furthermore, it involves a method for effectively delivering nucleic acids to cells, tissues, or organisms using the composition or formulation, as well as its medical applications.Type: ApplicationFiled: November 16, 2022Publication date: December 12, 2024Applicant: SUZHOU HEALIRNA BIOTECHNOLOGY CO., LTD.Inventors: Lixiang ZHAO, Qingqing Lu, Yawen Fan, Cheng YI, Youzhen Ge, Dan Xia, Hongpeng Hu
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Patent number: 12057261Abstract: The present application relates to the technical field of electromagnetic-isolation shielding materials, and in particular to a heat-resistant nanocrystalline magnetic-isolation shielding material and a preparation method and application thereof. The preparation method includes the following steps: S1, applying a double-sided adhesive tape onto a nanocrystalline soft-magnetic alloy ribbon to prepare a adhesive-coated nanocrystalline ribbon; S2, performing primary magnet cracking treatment on the adhesive-coated nanocrystalline ribbon to obtain a single-layered nanocrystalline magnetic layer; S3, performing multi-layer combination on the single-layered nanocrystalline magnetic layer to obtain a composite, and performing stress relief treatment on the composite to obtain a multi-layered nanocrystalline magnetic layer; and S4: performing secondary magnet cracking treatment on the multi-layered nanocrystalline magnetic layer to obtain a heat-resistant nanocrystalline magnetic-isolation shielding material.Type: GrantFiled: January 24, 2024Date of Patent: August 6, 2024Assignee: HANGZHOU QUADRANT TECHNOLOGY CO., LTD.Inventors: Zhijian Liu, Chengliang Ni, Li Feng, Guwei Wang, Dan Xia
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Patent number: 11683398Abstract: The embodiments of the present invention provide a method, apparatus for cross-protocol opportunistic routing, an electronic device, and a storage medium, the method includes: when there is a first data packet in a low-power wireless network, simulating the first data packet to generate a second data packet including to-be-transmitted data in the first data packet; obtaining identification information of a destination node in the first data packet, and selecting a low-power node with the lowest delay to the destination node in the low-power wireless network, except the first low-power node, as a forwarding low-power node based on the identification information of the destination node; sending the generated second data packet to the forwarding low-power node, so that the forwarding low-power node forwards the to-be-transmitted data to the destination node.Type: GrantFiled: October 19, 2021Date of Patent: June 20, 2023Assignee: BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONSInventors: Xiaolong Zheng, Dan Xia, Liang Liu, Huadong Ma
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Patent number: 11664886Abstract: A routing method and apparatus for SDN-based LEO satellite network are disclosed. The LEO satellite network includes a control plane and a data plane. The control plane includes a central controller and a plurality of local controllers. The data plane includes a plurality of LEO satellite nodes and user terminals connecting to the LEO satellite nodes. The control plane may be located on the earth, and thus the centralized management and control of the data plane are placed on the earth. A local controllers monitors LEO satellite nodes in a subnet or subnets of the local controller. The distance between a local controller and a LEO satellite node is much smaller than the distance between a GEO satellite node and the LEO satellite node, and thus the time delay and the traffic loss of communication are reduced.Type: GrantFiled: April 23, 2020Date of Patent: May 30, 2023Assignee: Beijing University of Posts and TelecommunicationsInventors: Liang Liu, Huadong Ma, Pengrui Duan, Dan Xia
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Patent number: 11607187Abstract: A multi-spectral tomography imaging system includes one or more source devices configured to direct beams of radiation in multiple spectra to a region of interest (ROI), and one or more detectors configured to receive the beams of radiation. The system includes a processor configured to cause movement in at least one of the components such that a first beam of radiation with a first spectrum is directed to the ROI for less than 360 degrees of movement of the ROI. The processor is also configured to process data detected by the one or more detectors, where the data results at least in part from the first beam of radiation with the first spectrum that is directed to the ROI for less than the 360 degrees of movement of the ROI. The processor is further configured to generate an image of the ROI based on the processed data.Type: GrantFiled: December 14, 2021Date of Patent: March 21, 2023Assignee: THE UNIVERSITY OF CHICAGOInventors: Xiaochuan Pan, Buxin Chen, Zheng Zhang, Emil Sidky, Dan Xia
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Publication number: 20220124179Abstract: The embodiments of the present invention provide a method, apparatus for cross-protocol opportunistic routing, an electronic device, and a storage medium, the method includes: when there is a first data packet in a low-power wireless network, simulating the first data packet to generate a second data packet including to-be-transmitted data in the first data packet; obtaining identification information of a destination node in the first data packet, and selecting a low-power node with the lowest delay to the destination node in the low-power wireless network, except the first low-power node, as a forwarding low-power node based on the identification information of the destination node; sending the generated second data packet to the forwarding low-power node, so that the forwarding low-power node forwards the to-be-transmitted data to the destination node.Type: ApplicationFiled: October 19, 2021Publication date: April 21, 2022Inventors: Xiaolong Zheng, Dan Xia, Liang Liu, Huadong Ma
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Publication number: 20220104783Abstract: A multi-spectral tomography imaging system includes one or more source devices configured to direct beams of radiation in multiple spectra to a region of interest (ROI), and one or more detectors configured to receive the beams of radiation. The system includes a processor configured to cause movement in at least one of the components such that a first beam of radiation with a first spectrum is directed to the ROI for less than 360 degrees of movement of the ROI. The processor is also configured to process data detected by the one or more detectors, where the data results at least in part from the first beam of radiation with the first spectrum that is directed to the ROI for less than the 360 degrees of movement of the ROI. The processor is further configured to generate an image of the ROI based on the processed data.Type: ApplicationFiled: December 14, 2021Publication date: April 7, 2022Inventors: Xiaochuan Pan, Buxin Chen, Zheng Zhang, Emil Sidky, Dan Xia
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Patent number: 11278254Abstract: A multi-spectral tomography imaging system includes one or more source devices configured to direct beams of radiation in multiple spectra to a region of interest (ROI), and one or more detectors configured to receive the beams of radiation. The system includes a processor configured to cause movement in at least one of the components such that a first beam of radiation with a first spectrum is directed to the ROI for less than 360 degrees of movement of the ROI. The processor is also configured to process data detected by the one or more detectors, where the data results at least in part from the first beam of radiation with the first spectrum that is directed to the ROI for less than the 360 degrees of movement of the ROI. The processor is further configured to generate an image of the ROI based on the processed data.Type: GrantFiled: September 21, 2018Date of Patent: March 22, 2022Assignee: THE UNIVERSITY OF CHICAGOInventors: Xiaochuan Pan, Buxin Chen, Zheng Zhang, Emil Sidky, Dan Xia
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Publication number: 20200343968Abstract: A routing method and apparatus for SDN-based LEO satellite network are disclosed. The LEO satellite network includes a control plane and a data plane. The control plane includes a central controller and a plurality of local controllers. The data plane includes a plurality of LEO satellite nodes and user terminals connecting to the LEO satellite nodes. The control plane may be located on the earth, and thus the centralized management and control of the data plane are placed on the earth. A local controllers monitors LEO satellite nodes in a subnet or subnets of the local controller. The distance between a local controller and a LEO satellite node is much smaller than the distance between a GEO satellite node and the LEO satellite node, and thus the time delay and the traffic loss of communication are reduced.Type: ApplicationFiled: April 23, 2020Publication date: October 29, 2020Inventors: Liang LIU, Huadong MA, Pengrui DUAN, Dan XIA
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Patent number: 10789738Abstract: An apparatus and method are provided for computed tomography (CT) imaging to reduce artifacts due to objects outside the field of view (FOV) of a reconstructed image. The artifacts are suppressed by using an iterative reconstruction method to minimize a cost function that includes a de-emphasis operator. The de-emphasis operator operates in the data domain, and minimizes the contributions of data inconsistencies arising from attenuation due to objects outside the FOV. This can be achieved by penalizing images that manifest indicia of artifacts due to outside objects especially those outside objects have high-attenuation densities and minimizing components of the data inconsistency likely attributable to the outside object.Type: GrantFiled: November 2, 2018Date of Patent: September 29, 2020Assignees: THE UNIVERSITY OF CHICAGO, CANON MEDICAL SYSTEMS CORPORATIONInventors: Xiaochuan Pan, Zheng Zhang, Dan Xia, Yu-Bing Chang, Jingwu Yao, Joseph Manak
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Publication number: 20200222016Abstract: A multi-spectral tomography imaging system includes one or more source devices configured to direct beams of radiation in multiple spectra to a region of interest (ROI), and one or more detectors configured to receive the beams of radiation. The system includes a processor configured to cause movement in at least one of the components such that a first beam of radiation with a first spectrum is directed to the ROI for less than 360 degrees of movement of the ROI. The processor is also configured to process data detected by the one or more detectors, where the data results at least in part from the first beam of radiation with the first spectrum that is directed to the ROI for less than the 360 degrees of movement of the ROI. The processor is further configured to generate an image of the ROI based on the processed data.Type: ApplicationFiled: September 21, 2018Publication date: July 16, 2020Inventors: Xiaochuan Pan, Buxin Chen, Zheng Zhang, Emil Sidky, Dan Xia
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Patent number: 10517543Abstract: A method and apparatus is provided to generate a multiresolution image having at least two regions with different pixel pitches. The multiresolution image is reconstructed using projection data having various pixel pitches corresponding to the pixel pitches of the multiresolution image. By using a higher resolution inside regions of interest (ROIs) in both the image and projection domains and lower resolution outside the ROIs, fast image reconstruction can be performed while avoiding truncation artifacts, which result imaging is limited to an ROI excluding attenuation regions. Further, those regions of greater clinical relevance and greater structural variance within the reconstructed images can be selected to be within the ROIs to improve the clinical benefit of the multiresolution image. The multiresolution image can be reconstructed using an iterative reconstruction method in which the high- and low-resolution regions are uniquely evaluated.Type: GrantFiled: September 13, 2017Date of Patent: December 31, 2019Assignees: The University of Chicago, Canon Medical Systems CorporationInventors: Xiaochuan Pan, Zheng Zhang, Dan Xia, Yu-Bing Chang, Joseph Manak
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Publication number: 20190139272Abstract: An apparatus and method are provided for computed tomography (CT) imaging to reduce artifacts due to objects outside the field of view (FOV) of a reconstructed image. The artifacts are suppressed by using an iterative reconstruction method to minimize a cost function that includes a de-emphasis operator. The de-emphasis operator operates in the data domain, and minimizes the contributions of data inconsistencies arising from attenuation due to objects outside the FOV. This can be achieved by penalizing images that manifest indicia of artifacts due to outside objects especially those outside objects have high-attenuation densities and minimizing components of the data inconsistency likely attributable to the outside object.Type: ApplicationFiled: November 2, 2018Publication date: May 9, 2019Applicants: THE UNIVERSITY OF CHICAGO, CANON MEDICAL SYSTEMS CORPORATIONInventors: Xiaochuan Pan, Zheng Zhang, Dan Xia, Yu-Bing Chang, Jingwu Yao, Joseph Manak
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Publication number: 20190076101Abstract: A method and apparatus is provided to generate a multiresolution image having at least two regions with different pixel pitches. The multiresolution image is reconstructed using projection data having various pixel pitches corresponding to the pixel pitches of the multiresolution image. By using a higher resolution inside regions of interest (ROIs) in both the image and projection domains and lower resolution outside the ROIs, fast image reconstruction can be performed while avoiding truncation artifacts, which result imaging is limited to an ROI excluding attenuation regions. Further, those regions of greater clinical relevance and greater structural variance within the reconstructed images can be selected to be within the ROIs to improve the clinical benefit of the multiresolution image. The multiresolution image can be reconstructed using an iterative reconstruction method in which the high- and low-resolution regions are uniquely evaluated.Type: ApplicationFiled: September 13, 2017Publication date: March 14, 2019Applicants: The University of Chicago, Toshiba Medical Systems CorporationInventors: Xiaochuan Pan, Zheng Zhang, Dan Xia, Yu-Bing Chang, Joseph Manak
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Patent number: 9840411Abstract: The present disclosure relates to a photoelectric conversion apparatus. The photoelectric conversion apparatus includes a carbon nanotube layer, a first thermoelectric conversion layer, a second thermoelectric conversion layer, a first electrode and a second electrode. The carbon nanotube layer includes a plurality of carbon nanotubes. An areal density of the carbon nanotube layer is in a range from about 0.16 g/m2 to about 0.32 g/m2.Type: GrantFiled: February 13, 2015Date of Patent: December 12, 2017Assignees: Tsinghua University, HON HAI PRECISION INDUSTRY CO., LTD.Inventors: Chang-Hong Liu, Dan Xia, Shou-Shan Fan
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Publication number: 20150243820Abstract: The present disclosure relates to a photoelectric conversion apparatus. The photoelectric conversion apparatus includes a carbon nanotube layer, a first thermoelectric conversion layer, a second thermoelectric conversion layer, a first electrode and a second electrode. The carbon nanotube layer includes a plurality of carbon nanotubes. An areal density of the carbon nanotube layer is in a range from about 0.16 g/m2 to about 0.32 g/m2.Type: ApplicationFiled: February 13, 2015Publication date: August 27, 2015Inventors: CHANG-HONG LIU, DAN XIA, SHOU-SHAN FAN
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Patent number: 9025843Abstract: A method and apparatus for reconstruction of a region of interest for an object is provided. The reconstruction of the object may be based on chords which may fill a part, all, or more than all of the region of interest. Using chords for reconstruction may allow for reducing data acquired and/or processing for reconstructing a substantially exact image of the ROI. Moreover, various methodologies may be used in reconstructing the image, such as backprojection-filtration, and modified filtration backprojection.Type: GrantFiled: February 20, 2012Date of Patent: May 5, 2015Assignee: The University of ChicagoInventors: Xiaochuan Pan, Yu Zou, Lifeng Yu, Chien-Min Kao, Martin King, Maryellen Giger, Dan Xia, Howard Halpern, Charles Pelizzari, Emil Y. Sidky, Seungryong Cho
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Publication number: 20120215090Abstract: A method and apparatus for reconstruction of a region of interest for an object is provided. The reconstruction of the object may be based on chords which may fill a part, all, or more than all of the region of interest. Using chords for reconstruction may allow for reducing data acquired and/or processing for reconstructing a substantially exact image of the ROI. Moreover, various methodologies may be used in reconstructing the image, such as backprojection-filtration, and modified filtration backprojection.Type: ApplicationFiled: February 20, 2012Publication date: August 23, 2012Inventors: Xiaochuan Pan, Yu Zou, Lifeng Yu, Chien-Min Kao, Martin King, Maryellen Giger, Dan Xia, Howard Halpern, Charles Pelizzari, Emil Y. Sidky, Seungryong Cho
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Patent number: 8121245Abstract: A method and apparatus for reconstruction of a region of interest for an object is provided. The reconstruction of the object may be based on chords which may fill a part, all, or more than all of the region of interest. Using chords for reconstruction may allow for reducing data acquired and/or processing for reconstructing a substantially exact image of the ROI. Moreover, various methodologies may be used in reconstructing the image, such as backprojection-filtration, and modified filtration backprojection.Type: GrantFiled: January 19, 2011Date of Patent: February 21, 2012Assignee: The University of ChicagoInventors: Xiaochuan Pan, Yu Zou, Lifeng Yu, Chien-Min Kao, Martin King, Maryellen Giger, Dan Xia, Howard Halpern, Charles Pelizzari, Emil Y. Sidky, Seungryong Cho