Abstract: A novel synthetic crystalline aluminogermanosilicate molecular sieve material, designated SSZ-116, is provided. SSZ-116 can be synthesized using 3-[(3,5-di-tert-butylphenyl)methyl]-1,2-dimethyl-1H-imidazolium cations as a structure directing agent. SSZ-116 may be used in organic compound conversion reactions and/or sorptive processes.

Abstract: Described herein is a technique for mapping the raw text of a job title of an online job posting to an entity embedding, associated with an entity or entry of a title taxonomy. The raw text of the job title is first encoded to generate a multilingual word embedding in a multilingual word embedding space. Then, the vector representation of the job title, as represented in the multilingual word embedding space is translated, using a neural network, to a vector representation of the job title in the entity embedding space. Finally, a nearest neighbor search is performed to identify an entity embedding associated with an entity or entry in the title taxonomy that has a vector representation that is closest in distance to the vector output by the neural network.

Abstract: A transcript of a conference (e.g., a video conference, an audio conference, or a telephone call with two or more participants) is processed to extract a conference summary. A graphical user interface is presented that enables a user to edit highlighting to select portions of a conference recording for inclusion in the conference summary. The user can edit highlighting on strings of a transcript and/or on a playback slide bar and the highlighting edits are propagated to both of these interfaces. Video clips selected for inclusion in a summary based on timestamps of strings in a transcript may be extended forward in time to incorporate a nearest I-frame of video. The short video or audio summary may be presented to users along with a text summary of the conference to enable efficient storage and transmission of information from the conference within a unified communications system.

Abstract: Methods of inhibiting the growth or metastasis of a cancer in a subject by inhibiting a Ral GTPase in the subject, and small molecule inhibitors of Ral GTPases useful in the methods of the invention. Pharmaceutical compositions containing the compounds of the invention, and methods of using the same.

Abstract: The present invention relates to anti-IL13 antibodies that bind specifically and with high affinity to both glycosylated and non-glycosylated human IL13, does not bind mouse IL13, and neutralize human IL13 activity at an approximate molar ratio of 1:2 (MAb:IL13). The invention also relates to the use of these antibodies in the treatment of IL13-mediated diseases, such as allergic disease, including asthma, allergic asthma, non-allergic (intrinsic) asthma, allergic rhinitis, atopic dermatitis, allergic conjunctivitis, eczema, urticaria, food allergies, chronic obstructive pulmonary disease, ulcerative colitis, RSV infection, uveitis, scleroderma, and osteoporosis.

Abstract: Chimeric Fc fusion polypeptides are provided, optionally including biologically active polypeptides for therapeutic use.

Abstract: A power amplifier is disclosed for amplifying an input signal and providing an amplified signal to a load at a junction node. The power amplifier comprises a splitter network, a carrier amplifier path and a peaking amplifier path. The peaking amplifier path comprises a first impedance transformer coupled between a peaking output matching network and the junction node to enhance the off-state impedance of the peaking amplifier. The carrier amplifier path comprises a second impedance transformer coupled between a carrier output matching network and the junction node.

Abstract: The present disclosure relates to optimizing one or more database tables that may include one or more redundant records. Records are clustered and assigned stable identifiers. In this manner, the underlying records within a cluster are not removed or deleted. As updates to the database are made, new clustering analyses are performed using the underlying records and any updates made. Newly identified clusters are reassigned stable identifiers.

Abstract: A power amplifier is disclosed for amplifying an input signal and providing an amplified signal to a load at a junction node. The power amplifier comprises a splitter network, a carrier amplifier path and a peaking amplifier path. The peaking amplifier path comprises a first impedance transformer coupled between a peaking output matching network and the junction node to enhance the off-state impedance of the peaking amplifier. The carrier amplifier path comprises a second impedance transformer coupled between a carrier output matching network and the junction node.

Abstract: The invention provides combinations comprising a MERTK inhibitor, or a pharmaceutically acceptable salt thereof, and an EGFR inhibitor and methods of use thereof, including methods of treating disorders such as cancer.

Abstract: An RSV reporter strain that can be used for high-throughput drug discovery is disclosed. Also disclosed is a recombinant RSV vector that contains an RSV genome encoding the disclosed RSV reporter strain operably linked to an expression control sequence. Also disclosed is an infectious RSV virion produce by expression of the disclosed recombinant RSV vector in a host cell. Also disclosed is a recombinant nucleic acid that comprises an RSV F protein having an escape mutation operably linked to a heterologous expression control sequence. Also disclosed are methods of screening for antiviral agents using the disclosed RSV reporter strains.

Abstract: The invention provides combinations comprising a MERTK inhibitor, or a pharmaceutically acceptable salt thereof, and an EGFR inhibitor and methods of use thereof, including methods of treating disorders such as cancer.

Abstract: An RSV reporter strain that can be used for high-throughput drug discovery is disclosed. Also disclosed is a recombinant RSV vector that contains an RSV genome encoding the disclosed RSV reporter strain operably linked to an expression control sequence. Also disclosed is an infectious RSV virion produce by expression of the disclosed recombinant RSV vector in a host cell. Also disclosed is a recombinant nucleic acid that comprises an RSV F protein having an escape mutation operably linked to a heterologous expression control sequence. Also disclosed are methods of screening for antiviral agents using the disclosed RSV reporter strains.

Abstract: An intraocular lens injector cartridge assembly contains a pre-loaded lens and an integral lens-contacting plunger rod. Configured for removably mating with an injector handpiece, the cartridge assembly is suitable for use with either manual or automated injector systems. The injector cartridge assembly includes a tubular body having a longitudinal bore extending between a distal end and a proximal end, an IOL disposed within said longitudinal bore, and a lens-contacting plunger rod retained within said bore, between the IOL and the proximal end of the tubular body. The lens-contacting plunger rod is configured for translation along the longitudinal bore upon engagement by an injector rod introduced by the injector handpiece into the proximal end of the tubular body, so that the IOL is folded and ejected from the distal end of the tubular body by the translation of the lens-contacting plunger rod.

Abstract: A sterility test method includes: selecting strain and culture medium, preparing bacterial cultures, transcribing fingerprint characteristics in thermograms as indices to verify the characteristics, drawing the thermodynamic parameters of the thermogram, determining the positive judgment index and performing sterility test for the samples. A fully-enclosed bacteria collecting ampoule incubator includes bacteria collecting ampoule system, sample and liquid feeding system and peristalsis liquid discharge system. The sample and liquid feeding system is connected with the bacteria collecting ampoule system by the liquid intake tube; and the bacteria collecting ampoule system is connected with the peristalsis liquid discharge system by the liquid drainage tube. The invention is characterized by short inspection time, high sensitivity, high automation and accurate test results on microbial contamination. It can also provide the overall process curve on the growth conditions.

Abstract: A sterility test method includes: selecting strain and culture medium, preparing bacterial cultures, transcribing fingerprint characteristics in thermograms as indices to verify the characteristics, drawing the thermodynamic parameters of the thermogram, determining the positive judgment index and performing sterility test for the samples. A fully-enclosed bacteria collecting ampoule incubator includes bacteria collecting ampoule system, sample and liquid feeding system and peristalsis liquid discharge system. The sample and liquid feeding system is connected with the bacteria collecting ampoule system by the liquid intake tube; and the bacteria collecting ampoule system is connected with the peristalsis liquid discharge system by the liquid drainage tube. The invention is characterized by short inspection time, high sensitivity, high automation and accurate test results on microbial contamination. It can also provide the overall process curve on the growth conditions.

Abstract: An intraocular lens injector cartridge assembly contains a pre-loaded lens and an integral lens-contacting plunger rod. Configured for removably mating with an injector handpiece, the cartridge assembly is suitable for use with either manual or automated injector systems. The injector cartridge assembly includes a tubular body having a longitudinal bore extending between a distal end and a proximal end, an IOL disposed within said longitudinal bore, and a lens-contacting plunger rod retained within said bore, between the IOL and the proximal end of the tubular body. The lens-contacting plunger rod is configured for translation along the longitudinal bore upon engagement by an injector rod introduced by the injector handpiece into the proximal end of the tubular body, so that the IOL is folded and ejected from the distal end of the tubular body by the translation of the lens-contacting plunger rod.