Abstract: The invention relates to the field of biomedicine, in particular to a T cell co-expressing CXCR2 and a Synthetic T-Cell Receptor and Antigen Receptor (STAR) against GPC3, and uses thereof.

Abstract: The present disclosure provides use of Clostridium ghonii combined with a tumor angiogenesis inhibitor in preparing a pharmaceutical product for treating a tumor. The present disclosure further provides a drug for treating a tumor, where the drug includes active ingredients of Clostridium ghonii and a tumor angiogenesis inhibitor.

Abstract: The present disclosure relates to use of a Clostridium ghonii spore combined with pembrolizumab in cancer treatment. It is found for the first time that the Clostridium ghonii spore combined with pembrolizumab can significantly improve a curative effect of colon cancer and reduce a dose of the pembrolizumab, and thus is efficient and low-toxic. Oncolysis by Clostridium ghonii can affect immunogenicity of a tumor microenvironment (TME) by various ways, converts an immunosuppressive state of the TME into an immune-activated state, adjusts the immunosuppressive TME, and breaks an immune tolerance. An optimal combination of the Clostridium ghonii spore and the pembrolizumab thoroughly removes about 20% of mouse tumor tissues. A benefit range of patients with tumors treated by a PD-1 antibody is expanded. The combination even has an obvious curative effect on patients failed the treatment by the PD-1 antibody.

Abstract: Disclosed herein is a method and a data processing system for environment evaluation, and a computer-readable storage medium with a computer program for executing the aforementioned method stored thereon. A data processing system according to one aspect comprises: at least one processor; at least one memory; and a computer program stored on the memory and executable on the processor, wherein execution of the computer program on the processor results in the following operations: obtaining user evaluations of an environment and environmental parameter measurements from a plurality of mobile devices; and generating evaluation information about the environment from the user evaluations and the environmental parameter measurements.

Abstract: A computing device receives a first user input that includes user selection of a first data field of a data source from a schema information region of a user interface and placement of the first data field into a data visualization region of the user interface. When the first data field corresponds to a geographic data field, the computing device determines longitude and latitude information for data values of the first data field. The computing device generates a map data visualization corresponding to the first data field according to the determined longitude and latitude information. The map data visualization includes a first layer having a first set of data marks corresponding to the first data field. The computing device displays, in the data visualization region, the map data visualization including the first set of data marks.

Abstract: A method generates map visualizations with multiple map layers. A user selects a data source with geographic data. A device displays a data visualization user interface, including a schema information region with data fields, and shelf regions that defining characteristics for a data visualization. The user selects a first geographic data, and the user interface generates a map data visualization using coordinates associated with the first geographic data field. The visualization includes a first plurality of data marks in a first layer. The user selects a second geographic data field. In response, the user interface displays a new layer icon. Upon activation of the new layer icon by the second geographic data field, the user interface superimposes a second layer over the existing map data visualization to form an updated map data visualization. The second layer includes a second plurality of data marks corresponding to the second geographic data field.

Abstract: The present invention provides lymphatic system-directing lipid prodrugs, pharmaceutical compositions thereof, methods of producing such prodrugs and compositions, and methods of improving the bioavailability or other properties of a therapeutic agent that comprises part of the lipid prodrug. The present invention also provides methods of treating a disease, disorder, or condition such as those disclosed herein, comprising administering to a patient in need thereof a disclosed lipid prodrug or a pharmaceutical composition thereof.

Abstract: A method generates map visualizations with multiple map layers. A user selects a data source with geographic data. A device displays a data visualization user interface, including a schema information region with data fields, and shelf regions that defining characteristics for a data visualization. The user selects a first geographic data, and the user interface generates a map data visualization using coordinates associated with the first geographic data field. The visualization includes a first plurality of data marks in a first layer. The user selects a second geographic data field. In response, the user interface displays a new layer icon. Upon activation of the new layer icon by the second geographic data field, the user interface superimposes a second layer over the existing map data visualization to form an updated map data visualization. The second layer includes a second plurality of data marks corresponding to the second geographic data field.

Abstract: An approach is provided for synchronizing elements in files across a technical environment. In one embodiment, a processor obtains a first change to a first file. The processor also obtains data identifying a second file. The processor determines if the change is supported by a data library in a pre-defined list of data sources. The processor analyzes the data library to determine a type of the change. The processor applies the type of the change to the second file.

Abstract: An elastic adjustable brake pad for use in a train, comprising a brake pad frame (1) provided with a fourth through hole (18), a brake block assembly, and a spiral compression spring (6); the brake block assembly comprises a brake block (16), a rivet (4), a Belleville spring (5), and a rivet sleeve (3), the brake block (16) comprising a friction block (10) and a static sheet steel back (7) fixedly mounted together, the rivet (4) passing through the brake block (16) and being sleeved in turn by the Belleville spring (5) and the rivet sleeve (3); the fourth through hole (18) is a stepped counterbore, and the rivet (4) in the brake block (16) penetrates the fourth through hole (18) and extends outward therefrom, the spiral compression spring (6) being sleeved over the outside of the rivet sleeve (3), and the outer side of one end of the rivet sleeve (3) being provided with a clamping groove clamped to an elastic retainer ring (2), one end of the spiral compression spring (6) abutting a step on which a secondary

Abstract: Systems and methods for change in language-based textual analysis are disclosed. In one embodiment, in an information processing apparatus comprising at least one computer processor, a method for change in language-based textual analysis may include: (1) retrieving, from a data source, a first document of a first type; (2) retrieving, from the data source, a second document of the first type, the second document being subsequent in time to the first document; (3) identifying changes between the first document and the second document; (4) calculating a change score based on the changes; and (5) providing the change score to a downstream system for projecting a performance of an investment associated with the first document.

Abstract: The present disclosure provides a display device and a method for assembling the same. The display device includes an electronic device and a flexible printed circuit board. The electronic device includes a lead region and a port located at the lead region, the flexible printed circuit board includes a first portion and a second portion. The first portion is a connector; the second portion includes connecting fingers through which the flexible printed circuit board is connected to the port through the connecting finger. The second portion of the flexible printed circuit board is arranged at a predetermined region, the predetermined region comprises the lead region and an extension region which is arranged outside the lead region and in a same plane where the lead region is located.

Abstract: Methods, systems, and computer program products for deriving a multi-pass matching algorithm for data de-duplication are provided herein. A method includes identifying multiple passes across multiple databases using a set of one or more blocking columns derived from a set of trained input data; identifying, in each of the multiple passes, one or more columns across the multiple databases that match one or more of the blocking columns; selecting a given pass from the multiple passes, wherein said given pass comprises a maximum number of matching columns within the multiple passes; determining, for the given pass, data that conform to the given pass comprising (i) a set of matching columns, (ii) one or more matching types and (iii) one or more weights; and determining one or more subsequent passes across the multiple databases iteratively by removing the data that conform to the given pass.

Abstract: An array substrate, a touch display device, and a driving method are provided. The array substrate includes a data line layer which includes a plurality of first touch electrodes; a common electrode layer which includes a plurality of second touch electrodes; and a first switch signal line. Each first touch electrode includes a plurality of data lines and a plurality of first switch elements, a control terminal (a) of the first switch element is connected to the first switch signal line, a first terminal (b) of the first switch element is connected one of the data lines in the first touch electrode, and a second terminal (c) of the first switch element is connected another of data lines in the first touch electrode, so that all of the data lines in the first touch electrode are electrically connected to each other upon the first touch electrode being turned on.

Abstract: An elastic adjustable brake pad for use in a train, comprising a brake pad frame (1) provided with a fourth through hole (18), a brake block assembly, and a spiral compression spring (6); the brake block assembly comprises a brake block (16), a rivet (4), a Belleville spring (5), and a rivet sleeve (3), the brake block (16) comprising a friction block (10) and a static sheet steel back (7) fixedly mounted together, the rivet (4) passing through the brake block (16) and being sleeved in turn by the Belleville spring (5) and the rivet sleeve (3); the fourth through hole (18) is a stepped counterbore, and the rivet (4) in the brake block (16) penetrates the fourth through hole (18) and extends outward therefrom, the spiral compression spring (6) being sleeved over the outside of the rivet sleeve (3), and the outer side of one end of the rivet sleeve (3) being provided with a clamping groove clamped to an elastic retainer ring (2), one end of the spiral compression spring (6) abutting a step on which a secondary

Abstract: Provided are a method and device for sending or acquiring a grant signalling. The method for sending a grant signalling includes: configuring one Multi-Physical Downlink Control Channel (M-PDCCH); and sending a grant signalling to N pieces of User Equipment (UE) through the M-PDCCH. By the technical solution, the technical problem that data throughput and spectral efficiency of a system are reduced by higher PDCCH overhead caused by the fact that one PDCCH or EPDCCH signalling can be granted to only one piece of UE in the related technology is solved, and the technical effect of improving the data throughput and spectral efficiency of the system is achieved.

Abstract: The present disclosure is directed to compositions comprising templated nanoconjugates and methods of their use.

Abstract: Embodiments of the present disclosure relate to the technical field of touch control display, and an array substrate and a touch control display device are provided. The array substrate includes a plurality of touch emitting lines and a plurality of touch sensing lines arranged perpendicular to each other and isolated from each other, each of the touch emitting lines and each of the touch sensing lines form a touch sensing capacitor. The touch sensing can be realized by sensing a variation in the capacitance value of the touch sensing capacitor when touch occurs. Meanwhile, the projection of each of the touch emitting lines or each of the touch sensing lines on the substrate falls into the projection of gate lines or data lines on the substrate, thus the aperture ratio of the touch control display device is increased.

Abstract: An approach is provided for synchronizing elements in files across a technical environment. In one embodiment, a processor obtains a first change to a first file. The processor also obtains data identifying a second file. The processor determines if the change is supported by a data library in a pre-defined list of data sources. The processor analyzes the data library to determine a type of the change. The processor applies the type of the change to the second file.

Abstract: An approach is provided for synchronizing elements in files across a technical environment. In one embodiment, a processor obtains a first change to a first file. The processor also obtains data identifying a second file. The processor determines if the change is supported by a data library in a pre-defined list of data sources. The processor analyzes the data library to determine a type of the change. The processor applies the type of the change to the second file.