Abstract: Provided herein are Pyrrolopyrimidine Compounds having the following structure: wherein R1, R2, R3, and L are as defined herein, compositions comprising an effective amount of a Pyrrolopyrimidine Compound, and methods for treating or preventing breast cancer, more particularly triple negative breast cancer, comprising administering an effective amount of such Pyrrolopyrimidine Compounds to a subject in need thereof.

Abstract: Aspects of this disclosure relate to reference switchover. In one embodiment, an apparatus includes a phase error detector, a phase alignment detector, and a selection circuit. The phase error detector is configured to generate an indication of a relative phase difference between a first reference clock signal and a second reference clock signal. The phase alignment detector is configured to receive the indication of the relative phase difference and determine when the relative phase difference satisfies a preset threshold. The selection circuit is configured to transition from providing the first reference clock signal as a clock system reference signal to providing the second reference clock signal as the clock system reference signal responsive to the phase alignment detector detecting that the relative phase difference satisfies the preset threshold.

Abstract: Provided herein are Pyrrolopyrimidine Compounds having the following structure: wherein R1, R2, R3, and L are as defined herein, compositions comprising an effective amount of a Pyrrolopyrimidine Compound, and methods for treating or preventing breast cancer, more particularly triple negative breast cancer, comprising administering an effective amount of such Pyrrolopyrimidine Compounds to a subject in need thereof.

Abstract: Provided herein are methods for treating or preventing a cancer, in particular solid tumors and hematological cancers, comprising administering to a subject in need thereof an effective amount of a compound of formula (I):

Abstract: An image forming apparatus includes: an image forming unit configured to form an image on a paper sheet; a conveying unit configured to convey the paper sheet to the image forming unit at a first conveyance speed and convey the paper sheet in the image forming unit at a second conveyance speed; a trouble detecting unit configured to detect a trouble; and a control unit configured to control the conveyance of the paper sheet in the conveying unit and the image formation on the paper sheet in the image forming unit, wherein, when the trouble detecting unit detects a trouble from the paper sheet being conveyed, and the control unit controls the conveying unit to perform a purging process to discharge a troubled paper sheet to the outside of the apparatus, the control unit controls a conveyance speed to be equal to the second conveyance speed.

Abstract: Aspects of this disclosure relate to reference switchover. In one embodiment, an apparatus includes a phase error detector, a phase alignment detector, and a selection circuit. The phase error detector is configured to generate an indication of a relative phase difference between a first reference clock signal and a second reference clock signal. The phase alignment detector is configured to receive the indication of the relative phase difference and determine when the relative phase difference satisfies a preset threshold. The selection circuit is configured to transition from providing the first reference clock signal as a clock system reference signal to providing the second reference clock signal as the clock system reference signal responsive to the phase alignment detector detecting that the relative phase difference satisfies the preset threshold.

Abstract: Adhesives made from phosphorylated legume and oil seed flours are described. The adhesive composition includes water and a legume and/or oil seed flour in which at least a portion of ?-amino moieties in lysine residues present in the flour are phosphorylated. An oxidizing agent may also optionally be added to the adhesive composition.

Abstract: Provided herein are Pyrrolopyrimidine Compounds having the following structure: wherein R1, R2, R3, and L are as defined herein, compositions comprising an effective amount of a Pyrrolopyrimidine Compound, and methods for treating or preventing breast cancer, more particularly triple negative breast cancer, comprising administering an effective amount of such Pyrrolopyrimidine Compounds to a subject in need thereof.

Abstract: Provided herein are Pyrrolopyrimidine Compounds having the following structure: wherein R1, R2, R3, and L are as defined herein, compositions comprising an effective amount of a Pyrrolopyrimidine Compound, and methods for treating or preventing breast cancer, more particularly triple negative breast cancer, comprising administering an effective amount of such Pyrrolopyrimidine Compounds to a subject in need thereof.

Abstract: The present invention relates to a novel crystalline form of a Compound 3,4?,5-trihydroxy-stilbene-3-?-D-glucoside (polydatin) and a method of preparation and use thereof, and to a pharmaceutical composition containing crystalline form I of 3,4?,5-trihydroxy-stilbene-3-?-D-glucoside. Crystalline form I of 3,4?,5-trihydroxy-stilbene-3-?-D-glucoside of the present invention has a stable crystalline morphology, a definite melting point and a good chemical stability. Such a novel form of 3,4?,5-trihydroxy-stilbene-3-?-D-glucoside possesses the properties required for the preparation of solid formulations and is easily tabletable and readily formable when formulated, which allows for substantial decrease in raw materials costs, more facile operations in production and easier control over quality in industrial drug production, and moreover, better convenience in storage.

Abstract: A clock system includes a digital phase/frequency detector (DPFD), a buffer, a digitally-controlled oscillator (DCO) including a sigma-delta modulator (SDM), an adder, a first frequency divider. The DPFD may have a first input for a reference input clock and a second input for a feedback signal, and outputting a difference signal representing a phase and/or frequency difference between the reference input clock and the feedback signal. The first frequency divider may have an input for a clock signal and a control input coupled to the adder. The system clock also may include a phase-locked loop (PLL) including a phase/frequency detector that has a first input coupled to the output of the DCO and a second input that is phase-locked to the first input, and a second frequency divider coupled from the second input of the PLL to the second input of the DPFD.

Abstract: A system that permits a retailer to have an in-store computer terminal that is connected to the Internet and configured to access a set of pages on a supplier's server. The accessible pages show a set of merchandise items selected by the retailer and tagged with prices set by the retailer. The terminal is either made available for direct ordering by a retail customer, or ordering by store personnel at the request of a retail customer. Changes in wholesale price or models offered may cause an automatic updating of the display pages, to avoid suboptimal pricing, inaccurate display and orders of unavailable items.

Abstract: A clock system includes a digital phase/frequency detector (DPFD), a buffer, a digitally-controlled oscillator (DCO) including a sigma-delta modulator (SDM), an adder, a first frequency divider. The DPFD may have a first input for a reference input clock, a second input for a feedback signal, the DPFD generating an output representing a difference between the reference input clock and the feedback signal. The buffer may be coupled to the DPFD for storing the difference signal over time. The SDM may have a control input coupled to the buffer. The adder may have inputs coupled to the SDM and a source of an integer control word. The first frequency divider may have an input for receiving an external clock signal and a control input coupled to the adder, the DCO generating an output clock signal having an average frequency representing a frequency of the external clock signal divided by (N+F/M).

Abstract: A clock system includes a digital phase/frequency detector (DPFD), a buffer, a digitally-controlled oscillator (DCO) including a sigma-delta modulator (SDM), an adder, a first frequency divider. The DPFD may have a first input for a reference input clock, a second input for a feedback signal, the DPFD generating an output representing a difference between the reference input clock and the feedback signal. The buffer may be coupled to the DPFD for accumulating the difference signal over time. The sigma-delta modulator (SDM) may have a control input coupled to the buffer. The adder may have inputs coupled to the (SDM) and a source of an integer control word. The first frequency divider may have an input for a clock signal and a control input coupled to the adder, the DCO generating an output clock signal having an average frequency representing a frequency of the input clock signal divided by (N+F/M), wherein N is determined by the integer control word and F/M is determined by an output of the SDM.

Abstract: A clock system includes a digital phase/frequency detector (DPFD), a buffer, a digitally-controlled oscillator (DCO) including a sigma-delta modulator (SDM), an adder, a first frequency divider. The DPFD may have a first input for a reference input clock and a second input for a feedback signal, and outputting a difference signal representing a phase and/or frequency difference between the reference input clock and the feedback signal. The buffer may be coupled to the DPFD for accumulating the difference signal over time. The sigma-delta modulator (SDM) may have a control input coupled to the buffer. The adder may have inputs coupled to the (SDM) and a source of an integer control word.

Abstract: The present invention relates to a surface chemically modified organic high polymer nanometer powder and its preparation method. The phosphoric acid modified nanometer powdery material of the present invention is polyether polyurethane or polyester polyurethane nanometer powder. The surface of the powder has self-assembled phosphate groups. It is prepared by the following method: phosphate groups are introduced into polyether polyurethane or polyester polyurethane nanometer powder in a phosphoric acid buffer solution by means of physical adsorption. This method can improve the stability and dispersibility of the powder and change its physical, chemical and biological properties and hopefully will realize intensive and extensive application in biomedical field. The surface modified nanometer powder of the present invention is in a controllable size of 50 nm˜500 nm and its surface Zeta potential in physiological environment is negative.

Abstract: A system that permits a retailer to have an in-store computer terminal that is connected to the Internet and configured to access a set of pages on a supplier's server. The accessible pages show a set of merchandise items selected by the retailer and tagged with prices set by the retailer. The terminal is either made available for direct ordering by a retail customer, or ordering by store personnel at the request of a retail customer. Changes in wholesale price or models offered may cause an automatic updating of the display pages, to avoid suboptimal pricing, inaccurate display and orders of unavailable items.

Abstract: The present invention provides novel compositions and methods for producing protein-polysaccharide conjugates in aqueous solutions. Also provided are methods for limiting the Maillard reaction to the very initial stage, the formation of the Schiff base. Provided are methods to obtain a simple product of Schiff base with white color, and compositions obtained using the methods of the present invention.

Abstract: The present invention relates to a novel crystalline form of a Compound 3,4?,5-trihydroxy-stilbene-3-?-D-glucoside (polydatin) and a method of preparation and use thereof, and to a pharmaceutical composition containing crystalline form I of 3,4?,5-trihydroxy-stilbene-3-?-D-glucoside. Crystalline form I of 3,4?,5-trihydroxy-stilbene-3-?-D-glucoside of the present invention has a stable crystalline morphology, a definite melting point and a good chemical stability. Such a novel form of 3,4?,5-trihydroxy-stilbene-3-?-D-glucoside possesses the properties required for the preparation of solid formulations and is easily tabletable and readily formable when formulated, which allows for substantial decrease in raw materials costs, more facile operations in production and easier control over quality in industrial drug production, and moreover, better convenience in storage.

Abstract: A composition includes polydatin and solvent for dissolving the polydatin, wherein the solvent comprises alcohol in a range between 40 and 95% by volume, propanediol in a range between 0 and 60% by volume, and water in remaining volume. The concentration of the polydatin must be at least 6 mg/ml. The composition has good stability in cold preservation. The composition is in a pharmaceutically acceptable administrative form selected from the group consisting of an intravenous injection, and intramuscular injection, an oral administration, a spray solution, and an aerosol form.