Abstract: Provided herein are host cells or host cellular expression systems that express a membrane protein. Also, methods are provided that use such host cells or host cellular expression systems to produce higher amounts of the membrane proteins. Further, the cells or cellular systems can be used as tools for the functional characterization of membrane proteins, as well as for screening and drug discovery efforts targeting membrane proteins.

Abstract: Provided herein are host cells or host cellular expression systems that express a membrane protein. Also, methods are provided that use such host cells or host cellular expression systems to produce higher amounts of the membrane proteins. Further, the cells or cellular systems can be used as tools for the functional characterization of membrane proteins, as well as for screening and drug discovery efforts targeting membrane proteins.

Abstract: Disclosed herein are antibacterial and antimicrobial compositions and methods of use. Also disclosed are screening assays for identification of an agent that specifically inhibits DsbB or bVKOR. Such methods are useful, for example, in identifying antibacterial and antimicrobial agents and compositions.

Abstract: Aspects of the invention relate to a method for inhibiting the growth of a microbe that expresses bacterial vitamin K epoxide reductase (bVKOR). The method involves contacting the bacterial cell with an effective amount of an agent that inhibits bVKOR. Agents include a drug, ligand or portion thereof, protein, polypeptide, small organic molecule, antisense nucleic acid, RNAi, or antibody. Examples of useful agents are a phenylpropanoid, a modified phenylpropanoid, a coumarin or modified coumarin. A particularly useful agents is warfarin or a variant thereof or ferulenol or a variant thereof. The microbe is any microbe carrying a bVKOR gene, such as Mycobacterium tuberculosis.

Abstract: A coextruded opaque multilayer film comprises an opaque thermoplastic polymer core and pigmented color layers on both sides of the core provided the composition of the core is different from the compositions of the pigmented color layers, and the pigmented color layers are not black or gray. The inventive film provides a method to vary the color or colors of the outer surfaces of the film which is advantageous in the variety of obtainable colors and also in cost when less expensive pigments are used in the opaque core which allows using less of expensive pigments in the pigmented color layers.

Abstract: The present invention relates to a halogen-free, multilayered, uniaxially oriented heat shrink film comprising (A) a core layer comprising a blend of polyolefins; (B) a first skin layer on the upper surface of the core layer, and (C) a second skin layer on the lower surface of the core layer, wherein the first and second skin layers independently comprise a polyolefin blend and wherein the shrinkage of the film is at least about 40% in the machine direction at 270° F. The present invention further relates to a label having an adhesive applied to at least a portion of at least one of the skin layers of the multilayered heat shrink film. The heat shrink labels of the present invention are used to encapsulate articles.

Abstract: The present invention relates to a halogen-free, multilayered, uniaxially oriented heat shrink film comprising (A) a core layer comprising a blend of polyolefins; (B) a first skin layer on the upper surface of the core layer, and (C) a second skin layer on the lower surface of the core layer, wherein the first and second skin layers independently comprise a polyolefin blend and wherein the shrinkage of the film is at least about 40% in the machine direction at 270° F.