Patents by Inventor Dana C. Baiu

Dana C. Baiu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Phospholipid Ether Analogs for Imaging and Targeted Treatment of Pediatric Solid Tumors
    Publication number: 20220008442
    Abstract: It is disclosed herein that that certain alkylphosphocholine analogs are preferentially taken up by malignant pediatric tumor cells. The alkylphophocholine analogs are compounds having the formula: or salts thereof, wherein n is an integer from 12 to 24; and R2 is —N+(CH3)3. The compounds can be used to treat pediatric solid tumors or to detect pediatric solid tumors. In therapeutic treatment, R1 includes a radioactive iodine isotope that locally delivers therapeutic dosages of radiation to the malignant pediatric tumor cells that preferentially take up the compound. In detection/imaging applications, R1 includes a detection moiety, such as a fluorophore or a radioactive iodine isotope.
    Type: Application
    Filed: September 21, 2021
    Publication date: January 13, 2022
    Inventors: Mario Otto, Dana C. Baiu, Bryan P. Bednarz, Jamey Paul Weichert
  • Phospholipid ether analogs for imaging and targeted treatment of pediatric solid tumors
    Patent number: 11147823
    Abstract: It is disclosed herein that that certain alkylphosphocholine analogs are preferentially taken up by malignant pediatric tumor cells. The alkylphophocholine analogs are compounds having the formula: or salts thereof, wherein n is an integer from 12 to 24; and R2 is —N+(CH3)3. The compounds can be used to treat pediatric solid tumors or to detect pediatric solid tumors. In therapeutic treatment, R1 includes a radioactive iodine isotope that locally delivers therapeutic dosages of radiation to the malignant pediatric tumor cells that preferentially take up the compound. In detection/imaging applications, R1 includes a detection moiety, such as a fluorophore or a radioactive iodine isotope.
    Type: Grant
    Filed: July 12, 2017
    Date of Patent: October 19, 2021
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Mario Otto, Dana C. Baiu, Bryan P. Bednarz, Jamey Paul Weichert
  • Phospholipid Ether Analogs for Imaging and Targeted Treatment of Pediatric Solid Tumors
    Publication number: 20180015113
    Abstract: It is disclosed herein that that certain alkylphosphocholine analogs are preferentially taken up by malignant pediatric tumor cells. The alkylphophocholine analogs are compounds having the formula: or salts thereof, wherein n is an integer from 12 to 24; and R2 is —N+(CH3)3. The compounds can be used to treat pediatric solid tumors or to detect pediatric solid tumors. In therapeutic treatment, R1 includes a radioactive iodine isotope that locally delivers therapeutic dosages of radiation to the malignant pediatric tumor cells that preferentially take up the compound. In detection/imaging applications, R1 includes a detection moiety, such as a fluorophore or a radioactive iodine isotope.
    Type: Application
    Filed: July 12, 2017
    Publication date: January 18, 2018
    Inventors: Mario Otto, Dana C. Baiu, Bryan P. Bednarz, Jamey Paul Weichert