Patents by Inventor Dana E. Selley

Dana E. Selley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Potent and selective mu opioid receptor modulators
    Patent number: 10988481
    Abstract: Analogues of 6 ?/?-naltrexamine (NAQ) are provided. The analogues are selective, reversible antagonists of the mu opioid receptor (MOR) that exhibit good blood brain barrier penetration. The compounds are used in the treatment of opioid addiction and other diseases and conditions, including for the treatment of pain.
    Type: Grant
    Filed: May 16, 2017
    Date of Patent: April 27, 2021
    Assignee: Virginia Commonwealth University
    Inventors: Yan Zhang, Dana E. Selley, William Dewey, Hamid Abkarali
  • POTENT AND SELECTIVE MU OPIOID RECEPTOR MODULATORS
    Publication number: 20190152982
    Abstract: Analogues of 6 ?/?-naltrexamine (NAQ) are provided. The analogues are selective, reversible antagonists of the mu opioid receptor (MOR) that exhibit good blood brain barrier penetration. The compounds are used in the treatment of opioid addiction and other diseases and conditions, including for the treatment of pain.
    Type: Application
    Filed: May 16, 2017
    Publication date: May 23, 2019
    Inventors: Yan ZHANG, Dana E. SELLEY, William DEWEY, Hamid ABKARALI
  • Bivalent ligands for the treatment of neurological disorders
    Patent number: 9107954
    Abstract: Bivalent ligands that contain two pharmacophores linked through a spacer, one of which interacts with the ?-opioid receptor (MOR) and the other of which interacts with the co-receptor CC chemokine receptor 5 (CCR5), are used for the treatment of neurological disorders such as those associated with AIDS.
    Type: Grant
    Filed: December 12, 2014
    Date of Patent: August 18, 2015
    Assignee: Virginia Commonwealth University
    Inventors: Yan Zhang, Kurt F. Hauser, Dana E. Selley
  • Bivalent Ligands for the Treatment of Neurological Disorders
    Publication number: 20150157730
    Abstract: Bivalent ligands that contain two pharmacophores linked through a spacer, one of which interacts with the ?-opioid receptor (MOR) and the other of which interacts with the co-receptor CC chemokine receptor 5 (CCR5), are used for the treatment of neurological disorders such as those associated with AIDS.
    Type: Application
    Filed: December 12, 2014
    Publication date: June 11, 2015
    Inventors: Yan Zhang, Kurt F. Hauser, Dana E. Selley
  • Non-peptidyl, potent, and selective mu opioid receptor antagonists and their use in treating opioid addiction and opioid induced constipation
    Patent number: 8980908
    Abstract: Selective, non-peptide antagonists of the mu opioid receptor (MOR) and methods of their use are provided. The antagonists may be used, for example, to identify MOR agonists in competitive binding assays, and to treat conditions related to addiction in which MOR is involved, e.g. heroin, prescription drug and alcohol addiction, as well as in the treatment of opioid induced constipation (OIC).
    Type: Grant
    Filed: May 27, 2014
    Date of Patent: March 17, 2015
    Assignee: Virginia Commonwealth University
    Inventors: Yan Zhang, Dana E. Selley, William Dewey
  • Bivalent ligands for the treatment of neurological disorders
    Patent number: 8946254
    Abstract: Bivalent ligands that contain two pharmacophores linked through a spacer, one of which interacts with the ?-opioid receptor (MOR) and the other of which interacts with the co-receptor CC chemokine receptor 5 (CCR5), are used for the treatment of neurological disorders such as those associated with AIDS.
    Type: Grant
    Filed: January 10, 2013
    Date of Patent: February 3, 2015
    Assignee: Virginia Commonwealth University
    Inventors: Yan Zhang, Kurt F. Hauser, Dana E. Selley
  • NON-PEPTIDYL, POTENT, AND SELECTIVE MU OPIOID RECEPTOR ANTAGONISTS AND THEIR USE IN TREATING OPIOID ADDICTION AND OPIOID INDUCED CONSTIPATION
    Publication number: 20140371255
    Abstract: Selective, non-peptide antagonists of the mu opioid receptor (MOR) and methods of their use are provided. The antagonists may be used, for example, to identify MOR agonists in competitive binding assays, and to treat conditions related to addiction in which MOR is involved, e.g. heroin, prescription drug and alcohol addiction, as well as in the treatment of opioid induced constipation (OIC).
    Type: Application
    Filed: May 27, 2014
    Publication date: December 18, 2014
    Applicant: Virginia Commonwealth University
    Inventors: Yan Zhang, Dana E. Selley, William Dewey
  • Bivalent Ligands for the Treatment of Neurological Disorders
    Publication number: 20140357656
    Abstract: Bivalent ligands that contain two pharmacophores linked through a spacer, one of which interacts with the ?-opioid receptor (MOR) and the other of which interacts with the co-receptor CC chemokine receptor 5 (CCR5), are used for the treatment of neurological disorders such as those associated with AIDS.
    Type: Application
    Filed: January 10, 2013
    Publication date: December 4, 2014
    Applicant: Virginia Commonwealth University
    Inventors: Yan Zhang, Kurt F. Hauser, Dana E. Selley
  • Non-peptidyl, potent, and selective mu opioid receptor antagonists
    Patent number: 8772308
    Abstract: Selective, non-peptide antagonists of the mu opioid receptor (MOR) and methods of their use are provided. The antagonists may be used, for example, to identify MOR agonists in competitive binding assays, and to treat conditions related to addiction in which MOR is involved, e.g. heroin, prescription drug and alcohol addiction.
    Type: Grant
    Filed: January 15, 2010
    Date of Patent: July 8, 2014
    Assignee: Virginia Commonwealth University
    Inventors: Yan Zhang, Dana E. Selley, William Dewey
  • NON-PEPTIDYL, POTENT, AND SELECTIVE MU OPIOID RECEPTOR ANTAGONISTS
    Publication number: 20110306628
    Abstract: Selective, non-peptide antagonists of the mu opioid receptor (MOR) and methods of their use are provided. The antagonists may be used, for example, to identify MOR agonists in competitive binding assays, and to treat conditions related to addiction in which MOR is involved, e.g. heroin, prescription drug and alcohol addiction.
    Type: Application
    Filed: January 15, 2010
    Publication date: December 15, 2011
    Inventors: Yan Zhang, Dana E. Selley, William Dewey