Abstract: Devices, systems, and methods for a robot-assisted surgery. Navigable instrumentation, which are capable of being navigated by a surgeon using the surgical robot system, and navigation software allow for the navigated placement of interbody fusion devices or other surgical devices.

Abstract: This patent discloses formulations, compositions, and process method and device, of hydrophobic extracts and biomass of Skin Tree, also called Mimosa tenuiflora, also called Mimosa cabrera, also called Mimosa hostilis, also called Jurema, also called Tepezcohuite, and apparatus used for cell repair, and the regeneration and rejuvenation of glabrous skin and hair bearing skin. The formulations and compositions herein disclosed, alone and when used with apparatus described, i.e. in combination, will serve to modulate cell repair and block inflammatory processes, infection and disease, reversing skin aging, thereby restoring normal cell and skin conditions, coloration, homeostasis, youth, vitality, and firmness.

Abstract: A cleaning composition for removing soils includes an aluminum salt, a hydroxycarboxylate, an alkalinity source and optionally, a surfactant system. The cleaning composition has a pH of between about 9 and about 14.

Abstract: A system and method for asset tracking and monitoring using antenna diversity. Antenna diversity ensures that the mobile terminal maintains good visibility of a satellite throughout the transport route. In one example, a first antenna is mounted on a first side of an asset transporter (e.g., flatbed trailer) and a second antenna is mounted on a second side of the asset transporter. A selector/combiner in the mobile terminal enables multiple antennas to be leveraged in the satellite communication process.

Abstract: A system and method for asset tracking and monitoring using antenna diversity. Antenna diversity ensures that the mobile terminal maintains good visibility of a satellite throughout the transport route. In one example, a first antenna is mounted on a first side of an asset transporter (e.g., flatbed trailer) and a second antenna is mounted on a second side of the asset transporter. A selector/combiner in the mobile terminal enables multiple antennas to be leveraged in the satellite communication process.

Abstract: A system and method for asset tracking and monitoring using antenna diversity. Antenna diversity ensures that the mobile terminal maintains good visibility of a satellite throughout the transport route. In one example, a first antenna is mounted on a first side of an asset transporter (e.g., flatbed trailer) and a second antenna is mounted on a second side of the asset transporter. A selector/combiner in the mobile terminal enables multiple antennas to be leveraged in the satellite communication process.

Abstract: Methods of treating diseases of the nervous system by administration of compositions having the neurological therapeutic activity of human erythropoietin are disclosed. These compositions include therapeutic agents such as peptides, peptide dimers, polypeptides, and proteins that have the full range of biological activity of human erythropoietin or only certain biological activities of erythropoietin. Improved therapeutic regimens where the erythropoietin is administered at concentrations below those required to stimulate hematopoiesis are also provided.

Abstract: Improved processes are provided for the production of alkyl aromatic compounds using zeolite catalyst(s) and for periodic reactivation in situ of zeolite catalyst(s) that have at least in part become deactivated. Processes according to this invention are typically carried out in a reaction section loaded with catalyst(s) wherein a desired alkyl aromatic compound is produced from feed aromatic and olefin compounds followed by a separation section in which the desired product is isolated and recovered. Alkylation, transalkylation, and/or isomerization reactions that occur in the reaction section are carried out in liquid phase or partial liquid phase over the said zeolite catalyst(s).

Abstract: The invention is directed to triazolopyridazine compounds of Formula I: where R1, R5, R6, R7, R8, and A are as defined herein, the use of such compounds as protein tyrosine kinase modulators, particularly inhibitors of c-Met, and the use of such compounds to reduce or inhibit kinase activity of c-Met in a cell or a subject, and modulate c-Met expression in a cell or subject, and the use of such compounds for preventing or treating in a subject a cell proliferative disorder and/or disorders related to c-Met. The present invention is further directed to pharmaceutical compositions comprising the compounds of the present invention and to methods for treating conditions such as cancers and other cell proliferative disorders.

Abstract: Methods of treating diseases of the nervous system by administration of compositions having the neurological therapeutic activity of human erythropoietin are disclosed. These compositions include therapeutic agents such as peptides, peptide dimers, polypeptides, and proteins that have the full range of biological activity of human erythropoietin or only certain biological activities of erythropoietin. Improved therapeutic regimens where the erythropoietin is administered at concentrations below those required to stimulate hematopoiesis are also provided.

Abstract: A method of reducing or inhibiting kinase activity of FLT3 in a cell or a subject, and the use of such compounds for preventing or treating in a subject a cell proliferative disorder and/or disorders related to FLT3 using a ompound of the present invention: or a solvate, hydrate, tautomer or pharmaceutically acceptable salt thereof. The present invention is further directed to methods for treating conditions such as cancers and other cell proliferative disorders.

Abstract: The invention is directed to N-substituted tricyclic 3-AMINOPYRAZOLE derivatives, which are useful as inhibitors of platelet-derived growth factor receptor (PDGF-R) kinase, and methods for the preparation of said derivatives. The present invention is further directed to pharmaceutical compositions comprising the compounds of the present invention and to methods for treating conditions such as tumors and other cell. proliferative disorders.

Abstract: The invention is directed to acylhydrazones compounds of Formula I: where R1, R2 and A are as defined herein, the use of such compounds as protein tyrosine kinase modulators, particularly inhibitors of c-Met, and the use of such compounds to reduce or inhibit kinase activity of c-Met in a cell or a subject, and modulate c-Met expression in a cell or subject, and the use of such compounds for preventing or treating in a subject a cell proliferative disorder and/or disorders related to c-Met. The present invention is further directed to pharmaceutical compositions comprising the compounds of the present invention and to methods for treating conditions such as cancers and other cell proliferative disorders.

Abstract: The invention relates to the discovery of triazolopyrimidine derivatives of formula (I), which have been found to exhibit inhibitory activity against the serine-tyrosine and tyrosine kinases.

Abstract: The invention is directed to a method of inhibiting FLT3 tyrosine kinase activity or expression or reducing FLT3 kinase activity or expression in a cell or a subject comprising the administration of a farnesyl transferase inhibitor and a FLT3 kinase inhibitor selected from alkylquinoline and alkylquinazoline compounds of Formula I?: where R1, R2, R3, Z, G, Q and X are as defined herein. Included within the present invention is both prophylactic and therapeutic methods for treating a subject at risk of (or susceptible to) developing a cell proliferative disorder or a disorder related to FLT3.

Abstract: The invention is directed to a method of inhibiting FLT3 tyrosine kinase activity or expression or reducing FLT3 kinase activity or expression in a cell or a subject comprising the administration of a farnesyl transferase inhibitor and a FLT3 kinase inhibitor selected from compounds of Formula I?: Included within the present invention is both prophylactic and therapeutic methods for treating a subject at risk of (or susceptible to) developing a cell proliferative disorder or a disorder related to FLT3.

Abstract: The invention is directed to alkylquinoline and alkylquinazoline compounds of Formula I: wherein R1, R2, R3, B, Z, G, Q and X are as defined herein, the use of such compounds as protein tyrosine kinase modulators, particularly inhibitors of FLT3 and/or c-kit and/or TrkB, the use of such compounds to reduce or inhibit kinase activity of FLT3 and/or c-kit and/or TrkB in a cell or a subject, and the use of such compounds for preventing or treating in a subject a cell proliferative disorder and/or disorders related to FLT3 and/or c-kit and/or TrkB. The present invention is further directed to pharmaceutical compositions comprising the compounds of the present invention and to methods for treating conditions such as cancers and other cell proliferative disorders.

Abstract: The invention features computer-assisted methods for identifying molecules which will bind to the EPO receptor and act as an erythropoietin (EPO) mimetic. Preferred EPO mimetics identified using the method of the invention act as agonists of the EPO receptor in one or more in vitro or in vivo biological assays of EPO activity.

Abstract: Improved integrated processes for the production of alkyl aromatic compounds are disclosed wherein aromatic compounds which may be treated for removal of deleterious substances are reacted with olefin compounds, which may also be treated for contaminant removal, in the presence of acidic zeolite catalyst(s) to produce the desired alkyl aromatic compound(s). The aromatic and preferably also the olefin feeds are treated substantially to remove contaminants, particularly the nitrogen compounds contained therein, before they are brought together for reaction in the presence of the zeolite catalyst(s). In accordance with the present invention, it has been found that feed pretreatment for removal of nitrogen compounds significantly improves the run length and life of the acidic zeolite catalyst(s). The feed pretreatment of this invention may include the steps of distillation, extraction, and/or adsorption by solid adsorbent, which may be regenerated in accordance with further embodiments of this invention.