Abstract: Provided herein are recombinant antibodies and antigen-binding fragments thereof useful for binding to and inhibiting carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1). Also provided are methods of using the disclosed CEACAM1 antibodies and antigen-binding fragments thereof for reducing T-cell tolerance and for the treatment of cancer.

Abstract: Provided herein are recombinant antibodies and antigen-binding portions thereof useful for binding to FcRn and blocking binding of FcRn to IgG Fc. The FcRn-binding proteins can be used to treat a variety of disorders including autoimmune disorders.

Abstract: Provided herein are recombinant antibodies and antigen-binding portions thereof useful for binding to FcRn and blocking binding of FcRn to IgG Fc. The FcRn-binding proteins can be used to treat a variety of disorders including autoimmune disorders.

Abstract: An automotive component (10) and a method for manufacturing the same are disclosed. The component (10) comprises a core portion (14) formed of a first material and a second portion (18) integral with the core portion (14) and formed of a second material. In one illustrated embodiment, the first and second materials have different material property characteristics. For example, the first material can be made of a relatively harder plastic material than the second material made of a softtouch plastic material. The method for manufacturing the component comprises the steps of injecting the first material into a first cavity of a mold to form the core portion (14), altering the mold cavity to form a second cavity and injecting the second material into the second cavity while the first material is in a reactive state to form the second portion (18) of the component. Because the first material is in the reactive state, the second material is integrally formed with the first material.

Abstract: An orthopedic treatment apparatus has a frame having a first movable platform having a platform frame movably attached to the frame for a reciprocating motion on a first pivot in a generally vertical motion. The first movable platform is also movably attached to said platform frame for a generally horizontal reciprocating motion on a second pivot. A first drive motor is attached to the frame and coupled to the first movable platform for driving the platform in a reciprocating motion relative to the frame while a second drive motor is attached to the first movable platform frame and coupled to the platform for moving the platform in a generally horizontal reciprocating motion relative to the frame.