Patents by Inventor Dana Larocca

Dana Larocca has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • EXOSOMES FROM CLONAL PROGENITOR CELLS
    Publication number: 20220403341
    Abstract: The invention provides methods, compositions, uses and kits relating to exosomes isolated from progenitor cells.
    Type: Application
    Filed: February 3, 2022
    Publication date: December 22, 2022
    Inventors: Dana Larocca, Mohammad Hassanipour, Paola A. Bignone
  • PERICYTE CELL EXOSOMES
    Publication number: 20220401494
    Abstract: Compositions and methods of use pertaining to exosomes, and more particularly to exosomes from pericytes and endothelial progenitor cells are presented.
    Type: Application
    Filed: February 3, 2022
    Publication date: December 22, 2022
    Inventors: Dana Larocca, Paola A. Bignone, Midori Greenwood-Goodwin
  • METHODS FOR DETECTING AND MODULATING THE EMBRYONIC-FETAL TRANSITION IN MAMMALIAN SPECIES
    Publication number: 20220160833
    Abstract: Aspects of the present invention include algorithms, methods and compositions related to the modulation of molecules regulating the mammalian transition from embryonic to fetal development. Methods and compositions for the use of such modulations to increase the regenerative potential in fetal and adult tissues otherwise incapable of scarless regeneration are also presented.
    Type: Application
    Filed: December 6, 2021
    Publication date: May 26, 2022
    Inventors: Michael D. West, Dana Larocca
  • PERIVASCULAR STROMAL CELLS FROM PRIMATE PLURIPOTENT STEM CELLS
    Publication number: 20220098554
    Abstract: The invention provides methods, compositions and kits for making and using pericyte-like cells or perivascular stromal cells derived from pPS cells.
    Type: Application
    Filed: June 29, 2021
    Publication date: March 31, 2022
    Inventors: Jiwei Yang, Dana Larocca, Midori Greenwood-Goodwin
  • METHODS FOR DETECTING AND MODULATING THE EMBRYONIC-FETAL TRANSITION IN MAMMALIAN SPECIES
    Publication number: 20220088138
    Abstract: Aspects of the present invention include algorithms, methods and compositions related to the modulation of molecules regulating the mammalian transition from embryonic to fetal development. Methods and compositions for the use of such modulations to increase the regenerative potential in fetal and adult tissues otherwise incapable of scarless regeneration are also presented.
    Type: Application
    Filed: December 6, 2021
    Publication date: March 24, 2022
    Inventors: Michael D. West, Dana Larocca
  • METHODS FOR DETECTING AND MODULATING THE EMBRYONIC-FETAL TRANSITION IN MAMMALIAN SPECIES
    Publication number: 20220088137
    Abstract: Aspects of the present invention include algorithms, methods and compositions related to the modulation of molecules regulating the mammalian transition from embryonic to fetal development. Methods and compositions for the use of such modulations to increase the regenerative potential in fetal and adult tissues otherwise incapable of scarless regeneration are also presented.
    Type: Application
    Filed: December 6, 2021
    Publication date: March 24, 2022
    Inventors: Michael D. West, Dana Larocca
  • Exosomes from clonal progenitor cells
    Patent number: 11274281
    Abstract: The invention provides methods, compositions, uses and kits relating to exosomes isolated from progenitor cells.
    Type: Grant
    Filed: February 7, 2019
    Date of Patent: March 15, 2022
    Assignee: ReCyte Therapeutics, Inc.
    Inventors: Dana Larocca, Mohammad Hassanipour, Paola A. Bignone
  • THERAPEUTIC EXOSOMES AND METHOD OF PRODUCING THEM
    Publication number: 20210338822
    Abstract: The invention provides improved methods, compositions, uses and kits relating to exosomes isolated from cells and therapeutic compositions and methods of using those exosomes. In one embodiment, the exosomes are loaded with one or more molecules to provide a desired therapeutic effect.
    Type: Application
    Filed: January 22, 2021
    Publication date: November 4, 2021
    Applicant: AgeX Therapeutics, Inc.
    Inventors: Dana LaRocca, Jieun Lee, Hal Sternberg
  • Perivascular stromal cells from primate pluripotent stem cells
    Patent number: 11078462
    Abstract: The invention provides methods, compositions and kits for making and using pericyte-like cells or perivascular stromal cells derived from pPS cells.
    Type: Grant
    Filed: February 18, 2015
    Date of Patent: August 3, 2021
    Assignee: ReCyte Therapeutics, Inc.
    Inventors: Jiwei Yang, Dana Larocca, Midori Greenwood-Goodwin
  • SUPERCENTENARIAN INDUCED PLURIPOTENT STEM (sciPS) CELLS AND METHODS OF MAKING AND USING THEREOF
    Publication number: 20210102175
    Abstract: Provided herein are cells and methods for reprogramming iPS cells from a supercentenarian and their differentiated derivatives having differences from non-supercentenarian iPS derived cells that contribute to disease resistance and longevity. Additionally, provided herein are methods for treatment and prevention of age related diseases by administration of therapeutic sciPS derived cells or cell derived reagents. Also provided herein, are methods for identifying reagents for treatment of age related diseases using sciPS cell-based assays.
    Type: Application
    Filed: December 2, 2020
    Publication date: April 8, 2021
    Inventor: Dana Larocca
  • INDUCED TISSUE REGENERATION USING EXTRACELLULAR VESICLES
    Publication number: 20200306296
    Abstract: Exosomes are generated from host embryonal carcinoma or embryonic progenitor cell lines and used for induced tissue regeneration. These inventive compositions and methods provide for induced tissue regeneration in aged or diseased mammalian tissues in vivo without the use of transgenically-expressed genes. Cells are reprogrammed to a prenatal, indeed a pre-fetal state, as indicated by for example in the case of many stromal cell types, by a decrease in the markers ADIRF and COX7A1.
    Type: Application
    Filed: March 27, 2020
    Publication date: October 1, 2020
    Applicant: AgeX Therapeutics, Inc.
    Inventors: Michael West, Dana Larocca, Jieun Lee
  • EXOSOMES FROM CLONAL PROGENITOR CELLS
    Publication number: 20190241873
    Abstract: The invention provides methods, compositions, uses and kits relating to exosomes isolated from progenitor cells.
    Type: Application
    Filed: February 7, 2019
    Publication date: August 8, 2019
    Inventors: Dana Larocca, Mohammad Hassanipour, Paola A. Bignone
  • METHODS AND COMPOSITIONS FOR TARGETING PROGENITOR CELL LINES
    Publication number: 20190218511
    Abstract: The invention provides methods, compositions and kits for the identification and enrichment of progenitor cell lines obtained from pluripotent stem cells.
    Type: Application
    Filed: January 22, 2019
    Publication date: July 18, 2019
    Inventors: Dana Larocca, Paola Bignone, Michael D. West, Evan Snyder
  • METHODS FOR DETECTING AND MODULATING THE EMBRYONIC-FETAL TRANSITION IN MAMMALIAN SPECIES
    Publication number: 20190175691
    Abstract: Aspects of the present invention include algorithms, methods and compositions related to the modulation of molecules regulating the mammalian transition from embryonic to fetal development. Methods and compositions for the use of such modulations to increase the regenerative potential in fetal and adult tissues otherwise incapable of scarless regeneration are also presented.
    Type: Application
    Filed: December 6, 2018
    Publication date: June 13, 2019
    Inventors: Michael D. West, Dana Larocca
  • PERICYTE CELL EXOSOMES
    Publication number: 20190151372
    Abstract: Compositions and methods of use pertaining to exosomes, and more particularly to exosomes from pericytes and endothelial progenitor cells are presented.
    Type: Application
    Filed: June 19, 2018
    Publication date: May 23, 2019
    Inventors: Dana Larocca, Paola A. Bignone, Midori Greenwood-Goodwin
  • Exosomes from clonal progenitor cells
    Patent number: 10240127
    Abstract: The invention provides methods, compositions, uses and kits relating to exosomes isolated from progenitor cells.
    Type: Grant
    Filed: June 23, 2015
    Date of Patent: March 26, 2019
    Assignee: ReCyte Therapeutics, Inc.
    Inventors: Dana Larocca, Mohammad Hassanipour, Paola A. Bignone
  • Methods and compositions for targeting progenitor cell lines
    Patent number: 10227561
    Abstract: The invention provides methods, compositions and kits for the identification and enrichment of progenitor cell lines obtained from pluripotent stem cells.
    Type: Grant
    Filed: November 2, 2015
    Date of Patent: March 12, 2019
    Assignees: Mandala Biosciences, LLC, BioTime, Inc., Sanford-Burnham Medical Research Institute
    Inventors: Dana Larocca, Paola Bignone, Michael D. West, Evan Snyder