Patents by Inventor Dana Nadler

Dana Nadler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Variant Cas9 polypeptides comprising internal insertions
    Patent number: 11008555
    Abstract: The present disclosure provides variant Cas9 polypeptides, where a variant Cas9 polypeptide of the present disclosure comprises an internal insertion of a heterologous polypeptide. The present disclosure provides nucleic acids comprising nucleotide sequences encoding the variant Cas9 polypeptides. The present disclosure provides host cells comprising a variant Cas9 polypeptide of the present disclosure, or comprising a nucleic acid encoding a variant Cas9 polypeptide of the present disclosure. The present disclosure provides methods of binding and/or modifying a target nucleic acid, involving use of a variant Cas9 polypeptide of the present disclosure.
    Type: Grant
    Filed: September 15, 2016
    Date of Patent: May 18, 2021
    Assignee: The Regents of the University of California
    Inventors: Benjamin Oakes, David Savage, Dana Nadler, Abraham I. Flamholz, Jennifer A. Doudna
  • VARIANT CAS9 POLYPEPTIDES COMPRISING INTERNAL INSERTIONS
    Publication number: 20200199552
    Abstract: The present disclosure provides variant Cas9 polypeptides, where a variant Cas9 polypeptide of the present disclosure comprises an internal insertion of a heterologous polypeptide. The present disclosure provides nucleic acids comprising nucleotide sequences encoding the variant Cas9 polypeptides. The present disclosure provides host cells comprising a variant Cas9 polypeptide of the present disclosure, or comprising a nucleic acid encoding a variant Cas9 polypeptide of the present disclosure. The present disclosure provides methods of binding and/or modifying a target nucleic acid, involving use of a variant Cas9 polypeptide of the present disclosure.
    Type: Application
    Filed: September 15, 2016
    Publication date: June 25, 2020
    Applicant: The Regents of the University of California
    Inventors: Benjamin Oakes, David Savage, Dana Nadler, Abraham I. Flamholz, Jennifer A. Doudna