Patents by Inventor Dana R. Leach

Dana R. Leach has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling
    Patent number: 7229628
    Abstract: T cell activation in response to antigen is increased by the administration of binding agents that block CTLA-4 signaling. When CTLA-4 signaling is thus blocked, the T cell response to antigen is released from inhibition. Such an enhanced response is useful for the treatment of tumors, chronic viral infections, and as an adjuvant during immunization.
    Type: Grant
    Filed: December 7, 1999
    Date of Patent: June 12, 2007
    Assignee: The Regents of the University of California, Office of Technology Transfer
    Inventors: James Patrick Allison, Dana R. Leach, Matthew E. Krummel
  • Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling
    Patent number: 6051227
    Abstract: T cell activation in response to antigen is increased by the administration of binding agents that block CTLA-4 signaling. When CTLA-4 signaling is thus blocked, the T cell response to antigen is released from inhibition. Such an enhanced response is useful for the treatment of tumors, chronic viral infections, and as an adjuvant during immunization.
    Type: Grant
    Filed: December 4, 1996
    Date of Patent: April 18, 2000
    Assignee: The Regents of the University of California, Office of Technology Transfer
    Inventors: James Patrick Allison, Dana R. Leach, Matthew F. Krummel
  • Blockade of lymphocyte down-regulation associated with CTLA-4 signaling
    Patent number: 5855887
    Abstract: T cell activation in response to antigen is increased by the administration of binding agents that block CTLA-4 signaling. When CTLA-4 signaling is thus blocked, the T cell response to antigen is released from inhibition. Such an enhanced response is useful for the treatment of tumors, chronic viral infections, and as an adjuvant during immunization.
    Type: Grant
    Filed: December 4, 1995
    Date of Patent: January 5, 1999
    Assignee: The Regents of the University of California
    Inventors: James Patrick Allison, Dana R. Leach, Matthew F. Krummel
  • Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling
    Patent number: 5811097
    Abstract: T cell activation in response to antigen is increased by the administration of binding agents that block CTLA-4 signaling. When CTLA-4 signaling is thus blocked, the T cell response to antigen is released from inhibition. Such an enhanced response is useful for the treatment of tumors, chronic viral infections, and as an adjuvant during immunization.
    Type: Grant
    Filed: May 8, 1996
    Date of Patent: September 22, 1998
    Assignee: The Regents of the University of California
    Inventors: James Patrick Allison, Dana R. Leach, Matthew F. Krummel