Patents by Inventor Dana R. Smulski

Dana R. Smulski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Yeast with increased butanol tolerance involving cell wall integrity pathway
    Patent number: 8795992
    Abstract: Increasing tolerance to butanol in yeast has been accomplished by increasing activity of the cell wall integrity pathway. Yeast with increased expression of SLT2p, a mitogen activated protein kinase of the MAPK module of the cell wall integrity pathway had increased tolerance to isobutanol. These yeast may be used for improved butanol production.
    Type: Grant
    Filed: December 21, 2009
    Date of Patent: August 5, 2014
    Assignee: Butamax Advanced Biofuels LLC
    Inventors: Michael G. Bramucci, Robert A. Larossa, Dana R. Smulski
  • Yeast with increased butanol tolerance involving high osmolarity/glycerol response pathway
    Patent number: 8455225
    Abstract: Increasing tolerance to butanol in yeast has been accomplished by increasing activity of the high osmolarity/glycerol response pathway. Yeast with increased expression of PBS2p, a mitogen activated protein kinase kinase of the MAPK module of the high osmolarity/glycerol response pathway may be used for improved butanol production.
    Type: Grant
    Filed: December 21, 2009
    Date of Patent: June 4, 2013
    Assignee: Butamax Advanced Biofuels LLC
    Inventors: Michael G. Bramucci, Robert A. Larossa, Dana R. Smulski
  • Production of four carbon alcohols using improved strain
    Patent number: 8372612
    Abstract: Using screening of transposon random insertion mutants, genes involved in accumulation of (p)ppGpp were found to be involved in bacterial cell response to butanol. Reduced production of proteins with enzymatic activity for (p)ppGpp biosynthesis confers increased butanol tolerance. Bacterial strains with reduced (p)ppGpp accumulation and having a butanol or 2-butanone biosynthetic pathway are useful for production of butanol or 2-butanone.
    Type: Grant
    Filed: December 9, 2008
    Date of Patent: February 12, 2013
    Assignee: Butamax(TM) Advanced Biofuels LLC
    Inventors: Robert A. Larossa, Dana R. Smulski, Vasantha Nagarajan
  • YEAST WITH INCREASED BUTANOL TOLERANCE INVOLVING HIGH OSMOLARITY/GLYCEROL RESPONSE PATHWAY
    Publication number: 20100167365
    Abstract: Increasing tolerance to butanol in yeast has been accomplished by increasing activity of the high osmolarity/glycerol response pathway. Yeast with increased expression of PBS2p, a mitogen activated protein kinase kinase of the MAPK module of the high osmolarity/glycerol response pathway may be used for improved butanol production.
    Type: Application
    Filed: December 21, 2009
    Publication date: July 1, 2010
    Applicant: Butamax (TM) Advanced Biofuels LLC
    Inventors: Michael G. Bramucci, Robert A. Larossa, Dana R. Smulski
  • YEAST WITH INCREASED BUTANOL TOLERANCE INVOLVING CELL WALL INTEGRITY PATHWAY
    Publication number: 20100167364
    Abstract: Increasing tolerance to butanol in yeast has been accomplished by increasing activity of the cell wall integrity pathway. Yeast with increased expression of SLT2p, a mitogen activated protein kinase of the MAPK module of the cell wall integrity pathway had increased tolerance to isobutanol. These yeast may be used for improved butanol production.
    Type: Application
    Filed: December 21, 2009
    Publication date: July 1, 2010
    Applicant: Butamax (TX) Advanced Biofuels LLC
    Inventors: MICHAEL G. BRAMUCCI, ROBERT A. LAROSSA, DANA R. SMULSKI
  • PRODUCTION OF FOUR CARBON ALCOHOLS USING IMPROVED STRAIN
    Publication number: 20090203139
    Abstract: Using screening of transposon random insertion mutants, genes involved in accumulation of (p)ppGpp were found to be involved in bacterial cell response to butanol. Reduced production of proteins with enzymatic activity for (p)ppGpp biosynthesis confers increased butanol tolerance. Bacterial strains with reduced (p)ppGpp accumulation and having a butanol or 2-butanone biosynthetic pathway are useful for production of butanol or 2-butanone.
    Type: Application
    Filed: December 9, 2008
    Publication date: August 13, 2009
    Inventors: Robert A. Larossa, Dana R. Smulski, Vasantha Nagarajan
  • STRAIN FOR BUTANOL PRODUCTION
    Publication number: 20090162911
    Abstract: Using screening of transposon random insertion mutants, genes involved in a complex that is a three-component proton motive force-dependent multidrug efflux system were found to be involved in E. coli cell response to butanol. Reduced production of the AcrA and/or AcrB proteins of the complex confers increased butanol tolerance. E. coli strains with reduced AcrA or AcrB production and having a butanol or 2-butanone biosynthetic pathway are useful for production of butanol or 2-butanone.
    Type: Application
    Filed: December 9, 2008
    Publication date: June 25, 2009
    Inventors: Robert A. Larossa, Dana R. Smulski