Abstract: The present invention relates to oral hydrogel compositions, more particularly to thermosensitive gel compositions, which undergo a sol-gel transition in the oral cavity, and which optionally comprise therapeutic actives for sustained release.

Abstract: Disclosed are a bare cell, a cylindrical battery and an assembly method of the bare cell. The bare cell is formed a cylinder by stacking and winding a first electrode plate, a separator and a second electrode plate, the polarity of the first electrode plate is opposite to the polarity of the second electrode plate, at least one of the first electrode plate and the second electrode plate forms a plurality of tabs at at least one end of the cylinder in an axial direction, each of the plurality of tabs is provided with at least one die-cutting line to form a plurality of sub-tabs, the plurality of tabs are bent and flattened in a radial direction, and the plurality of sub-tabs of two adjacent layers of the plurality of tabs are arranged in a staggered manner.

Abstract: The present disclosure discloses a method for controlling virtual objects. The method includes: displaying a first virtual object performing a scene exploration task in a virtual scene; in response to a move operation on the first virtual object, controlling the first virtual object to move in the virtual scene in a direction corresponding to the move operation; in a case where a second virtual object in a first state is present in the virtual scene, controlling the first virtual object to change a state of the second virtual object to a second state, wherein the second state is different from the first state; in a case where the second virtual object is in the second state, displaying the second virtual object in the second state following the first virtual object, wherein the second virtual object assists the first virtual object in performing the scene exploration task.

Abstract: The disclosure pertains to games. Disclosed are a method and apparatus for virtual object interaction, and a device and a computer-readable storage medium thereof. The method includes: displaying a first virtual object and a virtual resource within a virtual scene; displaying, in a case where a first condition is fulfilled, movement of virtual resource moves from a position where the virtual resource is located to a resource collection prop corresponding to the first virtual object; and displaying, in a case where a second condition is fulfilled, upgrade of resource-consuming equipment with virtual resources that have been collected by the resource collection prop corresponding to the first virtual object, to adjust or maintain an environment parameter for the first virtual object to survive within a target area affected by the resource-consuming equipment. This enhances game playability with diversified interactions of the virtual objects and more flexible interaction modes.

Abstract: A three-arm polyethylene glycol derivative containing amino acid moieties (Formula 1), wherein ni is the degree of polymerization and is an integer from 30 to 1000; R2 is C1-6 alkyl; L1A, L1B, and L2 are divalent linking groups; Lys is a lysine residue; AA1 and AA2 are residues of amino acids or amino acid derivatives; p is an integer from 1 to 5, with —(AA1)p—representing a divalent residue formed by p AA1 units; q is 0 or 1, indicating the absence or presence of AA2; L3 is a linking bond or divalent linking group; R01 is H or a functional group capable of reacting with bio-related substances, optionally protected; and m is 1 or 2. This derivative is degradable within cells, prevents vacuole formation at higher molecular weights, and can modify drugs or bio-related substances, offering high biocompatibility, low toxicity, and excellent drug activity retention.

Abstract: A battery module comprises a fixing component including a plurality of insertion posts, the insertion posts being sandwiched between a plurality of the cells. Further, the cell is provided with a fillet structure on the edges and the insertion post is connected to the fillet structure. According to the battery module, a plurality of removable reinforcement points are provided by a plurality of insertion posts, which do not affect the stacking density of the cells in the battery pack, and increasing the mechanical connection strength of the battery module. The removable design of the battery module and insertion posts solves the maintenance problem of the integrated battery pack and improves the safety of the battery module, featuring high structural strength, integrity and stability. A battery pack can include the battery module and an electric vehicle can include the battery pack.

Abstract: A nitrogen-branched non-linear PEGylated lipid containing a tertiary amine, which is represented by the Formula (1); wherein, B1 and B2 are linking bonds or alkylene groups; L1, L2, Ld and Lx are linking bonds or divalent linking groups L; R1 and R2 are C1-50 aliphatic hydrocarbon groups or C1-50 residues of aliphatic hydrocarbon derivative, each containing 0-10 heteroatoms; Ncore is a multivalent group of valence y+1 and contains a trivalent nitrogen-atom branching core connected to Ld; y is 2, 3, 4, 5, 6, 7, 8, 9, or ?10; XPEG are polyethylene glycol components. Compared with linear PEGylated lipids, the nitrogen-branched PEGylated lipid herein can realize better surface modification of LNP. The present invention also provides a lipid pharmaceutical composition and its formulation containing the PEGylated lipid, which can enhance the targeting ability of drugs and improve the transfection efficiency of nucleic acid drugs.

Abstract: A cationic lipid containing a disulfide bond of Formula (1), wherein, —S—S— is a disulfide bond; L1 and L2 are each independently a degradable divalent linking group, X1 and X2 are each independently an acyclic divalent linking group containing a tertiary amine group; G1 and G2 are each independently a linking bond or a trivalent branching group; when G1 is a linking bond, k1 is 1; when G1 is a trivalent branching group, k1 is 2; when G2 is a linking bond, k1 is 1; when G2 is a trivalent branching group, k2 is 2; R1 and R2 are each independently a substituted or unsubstituted C5-30 hydrocarbon group or C5-30 hydrocarbon derivative residue. The lipid composition prepared with the cationic lipid can more effectively exert the therapeutic effect of the LNP-nucleic acid pharmaceutical composition formulation, thereby improving immunological or therapeutic outcomes.

Abstract: A sodium ion battery cathode material and its preparation method and application, belonging to the field of sodium ion battery technology. The sodium ion battery cathode material includes a polyanionic iron-manganese core material and a fast ion conductor layer coated on the outer surface of said polyanionic iron-manganese core material; the polyanionic iron-manganese core material contains iron and manganese, and the iron and manganese are non-uniformly distributed within the polyanionic iron-manganese core material; at the center of the polyanionic iron-manganese core material, the manganese content is higher than the iron content; on the surface layer of the polyanionic iron-manganese core material, the iron content is higher than the manganese content. The non-uniform distribution of iron and manganese can effectively mitigate the risk of structural collapse caused by metal ion migration during cycling; the fast ion conductor coating reduces side reactions caused by electrolyte erosion.

Abstract: A free-radical in-situ polymerization semi-solid-state battery includes a positive electrode, a negative electrode and a semi-solid electrolyte. The semi-solid electrolyte is formed through in-situ polymerization by adding a polymerizable monomer, a plasticizer and an initiator into a liquid electrolyte. The polymerizable monomer is a combination of vinylene carbonate (VC) and trimethylene carbonate (TMC) with a mass ratio of 20 to 35:0.1 to 1.5. By optimizing the components of the gel electrolyte, the impedance of the battery is reduced, the performance of the battery is improved, the hardness of the gel electrolyte is enhanced, the solid-solid interface in the battery is benefited, and the safety of the battery is improved.

Abstract: A microfluidic flow channel structure and a microfluidic chip are described. The microfluidic flow channel structure includes a main chamber, wherein the main chamber includes at least two division zones and a reaction zone, and the at least two division zones are respectively connected with the reaction zone, wherein each division zone includes a first division wall, and the first division wall is provided with an opening for liquid inlet; a diversion structure is arranged at the opening of at least one division zone, and the diversion structure at least includes a first diversion wall, which is arranged opposite the first division wall; a first division channel is formed between the first diversion wall and the first division wall, and the first division channel includes at least two liquid outlets.

Abstract: Methods of shifting biofilm composition in an individual's oral cavity are disclosed. The methods comprise applying to the individual's oral cavity an oral care composition in an amount effective to shift biofilm composition to increase the amount from healthy bacteria in biofilm relative to pathogenic bacteria in biofilm. The oral care composition comprising: zinc oxide, zinc citrate, and arginine. The shift in biofilm composition provides a balance having a greater amount of healthy bacteria in biofilm compared to pathogenic bacteria.

Abstract: A unified mesh vertex indexing method for high-fidelity parallel full-core fast reactor simulation belongs to the fields of high performance computing and numerical simulation. Firstly, a constant is defined and a message passing interface (MPI) is initialized; processors then generate local hash tables concurrently to obtain local vertex numbers; next, a processor 0 generates a global hash table by MPI_Send( ) and MPI_Recv( ) functions, processes a conflict, and finally obtains global vertex numbers, thus building indexes. Local numbering and global numbering of mesh vertexes are realized with the hash table. Parallel processing of vertex numbering tasks of the processors is realized through the MPI. An innovative global vertex numbering method is provided for the processors. Large-scale parallel efficiency is improved. The research and development of large-scale high-fidelity numerical simulation software for a thermal fluid can be facilitated.

Abstract: Provided herein is an oral care composition comprising a basic amino acid or a salt thereof in an amount of from 0.001 weight % to 0.08 weight % by total weight of the composition, and an orally acceptable carrier. The composition is effective in accelerating HSP 27 production in damaged tissues of the oral cavity and enhances repair of the damaged tissue.

Abstract: Adapters are provided. An adapter includes at least one first sub-adapter. Each first sub-adapter includes: a first nucleotide single strand and a second nucleotide single strand, the first nucleotide single strand being complementarily paired with the second nucleotide single strand; and a first nucleotide single strand segment, the first nucleotide single strand segment being ligated to an end of the first nucleotide single strand or an end of the second nucleotide single strand. The first nucleotide single strand segment includes at least one random base and at least one adenine (A) base. Each random base is any one of an A base, a cytosine (C) base, a guanine (G) base and a thymine (T) base.

Abstract: The present invention discloses a non-linear PEGylated lipid, including the structure represented by the Formula (1); wherein, B1 and B2 are linking bonds or alkylene groups; L1 and L2 are linking bonds or divalent linking groups; Lx, Y, and Ld are divalent linking groups; R1 and R2 are C4-50 hydrocarbon groups or C4-50 residues of hydrocarbon derivative containing 1-4 heteroatoms; X is —CH< or n1, n2, and n3 are integers in the range of 4-250; T is a terminal group. Compared with linear PEGylated lipids, the non-linear PEGylated lipid provided herein can realize better protective effects toward the modified LNPs. The lipid pharmaceutical composition of the present invention exhibits high efficiency of drug encapsulation, appropriate particle size, non-toxicity, and good stability in serum. The LNP-nucleic acid pharmaceutical composition of the present invention demonstrates an excellent ability to complex with nucleic acids and shows high transfection activity.

Abstract: A non-linear PEGylated lipid of the Formula (1) contains a tertiary amine; wherein, B1 and B2 are linking bonds or alkylene groups; L1, L2, Ld, and Lx are linking bonds or divalent linking groups; R1 and R2 are C1-50 aliphatic hydrocarbon groups or C1-50 residues of aliphatic hydrocarbon derivatives, each containing 0-10 heteroatoms; y is 2 or 3; X is C or CH; XPEG is a polyethylene glycol component. Compared with linear PEGylated lipids, the PEGylated lipid can realize better surface modification of LNP, better protective effects, extended systemic circulation of LNP, and significantly reduced biological toxicity of LNP. The LNP pharmaceutical composition shows excellent drug delivery capabilities. The lipid-nucleic acid pharmaceutical composition and its formulation exhibit higher pharmaceutical efficacy, especially the LNP-nucleic acid pharmaceutical composition.

Abstract: A nitrogen-branched non-linear PEGylated lipid containing a tertiary amine, which is represented by the Formula (1); wherein, B1 and B2 are linking bonds or alkylene groups; L1, L2, Ld and Lx are linking bonds or divalent linking groups L; R1 and R2 are C1-50 aliphatic hydrocarbon groups or C1-50 residues of aliphatic hydrocarbon derivative, each containing 0-10 heteroatoms; Ncore is a multivalent group of valence y+1 and contains a trivalent nitrogen-atom branching core connected to Ld; y is 2, 3, 4, 5, 6, 7, 8, 9, or ?10; XPEG are polyethylene glycol components. Compared with linear PEGylated lipids, the nitrogen-branched PEGylated lipid herein can realize better surface modification of LNP. The present invention also provides a lipid pharmaceutical composition and its formulation containing the PEGylated lipid, which can enhance the targeting ability of drugs and improve the transfection efficiency of nucleic acid drugs.

Abstract: A nitrogen-branched non-linear PEGylated lipid of Formula (1), wherein, X is —CRa< or (Ra is H or a C1-12 alkyl group); B1 and B2 are linking bonds or C1-20 alkylene groups; L1 and L2 are linking bonds or divalent linking groups; R1 and R2 are C1-50 aliphatic hydrocarbon groups or C1-50 residues of aliphatic hydrocarbon derivative, each containing 0-10 heteroatoms; Ld is a linking bond or a divalent linking group; Ncore is a multivalent group of valence y+1, and contains a trivalent nitrogen-atom branching core connected to Ld; y is 2, 3, 4, 5, 6, 7, 8, 9, or ?10; Lx is a linking bond or a divalent linking group; XPEG is a polyethylene glycol component. The non-linear PEGylated lipid herein can realize better surface modification of LNP. The lipid nanoparticle pharmaceutical composition and its formulation exhibit higher drug efficacy, especially for nucleic acid drugs.

Abstract: Methods of identifying an individual as being a slow gingivitis responder or a high gingivitis responder are disclosed. Some methods are based on IL-1? levels in the individual's GCF at the site of inflammation. Some methods are based on MIF and/or CCL-1 levels in the individual's GCF in healthy tissue distant from the site of inflammation. Some disclosed methods are based on temporal differences in IL-8, IL-6 and/or TNF? levels in the individual's GCF in healthy tissue distant from the site of inflammation during the development of plaque induced inflammation. Methods of treating an individual who has gingivitis and methods of preventing gingivitis are also provided. The treatment and prevention methods comprise determining if individual is a slow gingivitis responder or a high gingivitis responder and applying oral care compositions to the individual's oral cavity.