Abstract: The present application relates to the use of CYP4V2 and RdCVF in the manufacture of a medicament for treating, alleviating, and/or preventing a disease or disorder associated with retinal pigment epithelium (RPE) atrophy. The present application also relates to an isolated nucleic acid molecule comprising a polynucleotide encoding CYP4V2 and a polynucleotide encoding RdCVF. The present application also relates to an amino acid sequence encoded by the isolated nucleic acid molecule, a vector comprising the isolated nucleic acid molecule, and a cell comprising the nucleic acid or the vector as well as use thereof in the manufacture of a medicament for treating, alleviating, and/or preventing a disease or disorder associated with retinal pigment epithelium (RPE) atrophy.

Abstract: A vector includes a polynucleotide encoding CYP4V2 and a promoter operably linked to the polynucleotide encoding CYP4V2. The vector has a good expression effect, high expression speed, and more stable expression intensity. Cells, pharmaceutical compositions, and kits can include the vector. Methods for treating, alleviating, and/or preventing a disease or disorder associated with retinal pigment epithelium (RPE) atrophy can include administering the vector to a subject.

Abstract: One or more embodiments herein relate to a method for an uplink transmission timing adjustment in a wireless communication device served by a network node and configured to operate in a coverage enhancement mode. The coverage enhancement mode comprises a repetitive transmission of a first uplink signal during a first repetition period. The method comprises determining a change in a downlink timing (210), determining whether the first repetition period is ongoing (240); and in response to the change in the downlink timing and the first repetition period being ongoing, performing an adjustment of an uplink transmission timing outside the first repetition period (260).

Abstract: The present application relates to a fusion protein and use thereof. The fusion protein comprises RdCVF and a signal peptide, wherein the signal peptide is an amino acid sequence set forth in any one of SEQ ID NOs: 27-31 and 33. The present application also relates to an isolated nucleic acid molecule comprising a) a polynucleotide encoding RdCVF and b) a polynucleotide encoding a signal peptide. The present application also provides a vector, a cell, and a pharmaceutical composition containing the nucleic acid molecule, as well as medical use thereof. The fusion protein and/or isolated nucleic acid molecule described herein can effectively increase the secretion of RdCVF.

Abstract: A distributed wireless system comprises a controlling node (20) and two or more antenna processing nodes (22) communicatively coupled to the controlling node (20) but spatially separated from each other and from the controlling node (20). A method in the controlling node (20) comprises controlling (1110) a first subset of the antenna processing nodes (22) to transmit synchronization signal blocks, SSBs, having a first SSB identifier, the first subset including one or more of the antenna processing nodes, and controlling (1120) a second subset of the antenna processing nodes (22) to transmit SSBs having a second SSB identifier, the second subset including one or more of the antenna processing nodes (22) and being disjoint with the first subset.

Abstract: The present application relates to the use of CYP4V2 and RdCVF in the manufacture of a medicament for treating, alleviating, and/or preventing a disease or disorder associated with retinal pigment epithelium (RPE) atrophy. The present application also relates to an isolated nucleic acid molecule comprising a polynucleotide encoding CYP4V2 and a polynucleotide encoding RdCVF. The present application also relates to an amino acid sequence encoded by the isolated nucleic acid molecule, a vector comprising the isolated nucleic acid molecule, and a cell comprising the nucleic acid or the vector as well as use thereof in the manufacture of a medicament for treating, alleviating, and/or preventing a disease or disorder associated with retinal pigment epithelium (RPE) atrophy.

Abstract: Embodiments disclosed herein relate to a method in a wireless communication device that operates in an enhanced coverage mode, the enhanced coverage mode comprising sequential repetition of messages sent from the wireless communication device to a network node. An example method includes: receiving a Timing Advance Command TAC from the network node; and adapting a time at which the TAC is applied, wherein a time difference between the time at which the TAC is applied and a time at which the TAC is received shall be greater than or equal to a specified time depending on a type of the used Radio Access Technology, such that application of the TAC does not occur during a period after a first subframe of a repeated uplink transmission till the end of the repeated uplink transmission.

Abstract: In an example embodiment, a system comprises a chain of serially coupled nodes, including a central processing node (CPN) and one or more radio communications nodes (RCNs). The CPN couples to a first RCN in the chain via a dielectric waveguide (DWG) link and any further RCNs in the chain are successively connected in serial fashion from the first RCN via further (DWG) links. The CPN generates outbound radio carrier signals that are waveguide-propagated in a downstream direction of the chain, for over-the-air (OTA) by targeted ones of the RCNs, while radio carrier signals received via OTA reception by respective ones of the RCNs are waveguide propagated as inbound radio signals in an upstream direction of the chain, for processing by the CPN. Advantages from he contemplated system include greatly simplified implementation of the RCNs, with lower cost and power consumption. Further, strategic placement of failover CPNs and DWG links provide for continued operation in the face of CPN or DWG link failures.

Abstract: Embodiments disclosed herein relate to a method in a wireless communication device that operates in an enhanced coverage mode, the enhanced coverage mode comprising sequential repetition of messages sent from the wireless communication device to a network node. An example method includes: receiving a Timing Advance Command TAC from the network node; and adapting a time at which the TAC is applied, wherein a time difference between the time at which the TAC is applied and a time at which the TAC is received shall be greater than or equal to a specified time depending on a type of the used Radio Access Technology, such that application of the TAC does not occur during a period after a first subframe of a repeated uplink transmission till the end of the repeated uplink transmission.

Abstract: Detection of Narrow-Band IOT (NB-IOT) Synchronization signal and Cyclic Prefix length determination at UE. The detection method implements symbol level correlation, comprising: filtering the radio signal with a plurality of matched filters to obtain a correlation for each OFDM symbol in the synchronization signal, wherein each matched filter provides a correlation with one OFDM symbol in the synchronization signal; delaying and combining the outputs of the plurality of matched filters in a first way to provide a first combined output for the normal cyclic prefix configuration and delaying and combining the outputs of the plurality of matched filters in a second way to provide a second combined output for the extended cyclic prefix configuration; and detecting a correlation peak indicative of the synchronization signal in one of the first or second combined outputs. The present disclosure also relates to a user equipment including the apparatus.

Abstract: Embodiments disclosed herein relate to a method in a wireless communication device that operates in an enhanced coverage mode, the enhanced coverage mode comprising sequential repetition of messages sent from the wireless communication device to a network node. An example method includes: receiving a Timing Advance Command TAC from the network node; and adapting a time at which the TAC is applied, wherein a time difference between the time at which the TAC is applied and a time at which the TAC is received shall be greater than or equal to a specified time depending on a type of the used Radio Access Technology, such that application of the TAC does not occur during a period after a first subframe of a repeated uplink transmission till the end of the repeated uplink transmission.

Abstract: One or more embodiments herein relate to a method for an uplink transmission timing adjustment in a wireless communication device served by a network node and configured to operate in a coverage enhancement mode. The coverage enhancement mode comprises a repetitive transmission of a first uplink signal during a first repetition period. The method comprises determining a change in a downlink timing (210), determining whether the first repetition period is ongoing (240); and in response to the change in the downlink timing and the first repetition period being ongoing, performing an adjustment of an uplink transmission timing outside the first repetition period (260).

Abstract: Detection of Narrow-Band IOT (NB-IOT) Synchronization signal and Cyclic Prefix length determination at UE. The detection method implements symbol level correlation, comprising: filtering the radio signal with a plurality of matched filters to obtain a correlation for each OFDM symbol in the synchronization signal, wherein each matched filter provides a correlation with one OFDM symbol in the synchronization signal; delaying and combining the outputs of the plurality of matched filters in a first way to provide a first combined output for the normal cyclic prefix configuration and delaying and combining the outputs of the plurality of matched filters in a second way to provide a second combined output for the extended cyclic prefix configuration; and detecting a correlation peak indicative of the synchronization signal in one of the first or second combined outputs. The present disclosure also relates to a user equipment including the apparatus.

Abstract: One or more embodiments herein relate to a method for an uplink transmission timing adjustment in a wireless communication device served by a network node and configured to operate in a coverage enhancement mode. The coverage enhancement mode comprises a repetitive transmission of a first uplink signal during a first repetition period. The method comprises determining a change in a downlink timing (210), determining whether the first repetition period is ongoing (240); and in response to the change in the downlink timing and the first repetition period being ongoing, performing an adjustment of an uplink transmission timing outside the first repetition period (260).

Abstract: Embodiments disclosed herein relate to a method in a wireless communication device that operates in an enhanced coverage mode, the enhanced coverage mode comprising sequential repetition of messages sent from the wireless communication device to a network node. An example method includes: receiving a Timing Advance Command TAC from the network node; and adapting a time at which the TAC is applied, wherein a time difference between the time at which the TAC is applied and a time at which the TAC is received shall be greater than or equal to a specified time depending on a type of the used Radio Access Technology, such that application of the TAC does not occur during a period after a first subframe of a repeated uplink transmission till the end of the repeated uplink transmission.

Abstract: The solution presented herein discloses a method of reducing inter-symbol jitter caused while processing each of a plurality of OFDM symbols in a received signal. For each of the plurality of OFDM symbols, the method comprises receiving a plurality of radio samples produced by a sampling of an OFDM symbol at a reduced sampling rate, where the reduced sampling rate causes inter-symbol jitter between the plurality of OFDM symbols. The method further comprises determining a sample offset corresponding to a symbol number for the OFDM symbol, transforming the samples of the OFDM symbol into a plurality of frequency-domain resource elements, and determining a phase offset for each of the resource elements using the sample offset. The method then reduces the inter-symbol jitter by rotating each resource element using the corresponding phase offset to generate phase-rotated resource elements.

Abstract: The solution presented herein discloses a method of transmitting first symbols via a transceiver comprising a receiver and a transmitter. The method comprises determining a timing discrepancy between a previous reference timing and a current reference timing. The current reference timing is established responsive to a reduced sampling rate used to process second symbols received by the receiver, where the reduced sampling rate is less than a minimum sampling rate at which an inter-symbol distance between the second symbols can be represented by an integer number of samples. The method further comprises adjusting the current reference timing responsive to the timing discrepancy to generate an adjusted reference timing, and determining an uplink transmission timing responsive to the adjusted reference timing. The method further comprises transmitting the first symbols via the transmitter according to the determined uplink transmission timing.