Abstract: The invention provides a 7-ethyl-10-hydroxycamptothecin drug precursor with fluorescence activity and a preparation method and use thereof. The method involves that a carboxyl group of a boron dipyrromethene dye molecule is condensed with a hydroxyl group at the 10 position of 7-ethyl-10-hydroxycamptothecin, yielding a 7-ethyl-10-hydroxy-camptothecin drug precursor (BDP-SN38) with fluorescent activity. BDP-SN38 shows good solubility and stability in most pharmaceutically acceptable solvents. Compared with SN38, BDP-SN38 exhibits comparable antitumor activity, has high tumor uptake capacity, and produces strong green fluorescence with the excitation of visible light, thus providing fluorescence-guided bioimaging and further treatment of residual tumors after drug treatment, and having good application prospects in the research of integrated diagnosis and treatment and effective tumor treatment.

Abstract: The present invention relates to the technical field of photosensitizers, and particularly to a near-infrared nano-photosensitizer and a preparation method and use thereof. The near-infrared nano-photosensitizer in the present invention is modified by conjugation extension of the boron dipyrromethene core, achieving absorption and emission spectra close to the near-infrared region. A polyfluoroalkyl group and a polyethylene glycol group are introduced to the boron dipyrromethene structure to obtain an amphiphilic photosensitizer. By means of the strong fluorine-fluorine interaction between the polyfluoroalkyl group and the hydrophilic interaction of the polyethylene glycol group, a nano-photosensitive micelle with an ultra-low CMC value is ultimately constructed. Boron dipyrromethene is induced by fluorine-fluorine interaction to undergo J-aggregation, causing the maximum absorption peak to red-shift to the near-infrared region, beneficial to the deep phototherapy of tumors.

Abstract: A platform for processing a workpiece includes a transmission mechanism, a plurality of workstations and a plurality of movable vehicles. The transmission mechanism transports the workpiece to be processed to one of the plurality of workstations. Each movable vehicle includes a processing module and a docking interface adapted to connect with a docking station of each workstation. The movable vehicles are each adapted to move in and out of each workstation, and each processing module is adapted to process the workpiece transmitted to the workstation after the movable vehicle is moved in and positioned in the workstation.

Abstract: The present invention discloses a capsaicin-derived photosensitizer, and a preparation method and use thereof. Boron-dipyrromethene is used as a core of the photosensitizer, which has a maximum absorption peak red-shifted to the near infrared region by expanding the ? system and is introduced with a capsaicin-targeting group to construct a capsaicin-derived photosensitizer cap-BDP with high-performance targeting of TRPV1 protein. The photosensitizer can generate singlet oxygen under low-power LED irradiation, which specifically activates the TRPV1 protein pathway, causes significant calcium influx, and induces apoptosis of tumor cells. Moreover, the generated singlet oxygen directly oxidizes endogenous substances in cells to cause cell apoptosis, eventually achieving light-induced bifunctional synergistic therapy.

Abstract: The present invention relates to the technical field of photosensitizers, and particularly to a near-infrared nano-photosensitizer and a preparation method and use thereof. The near-infrared nano-photosensitizer in the present invention is modified by conjugation extension of the boron dipyrromethene core, achieving absorption and emission spectra close to the near-infrared region. A polyfluoroalkyl group and a polyethylene glycol group are introduced to the boron dipyrromethene structure to obtain an amphiphilic photosensitizer. By means of the strong fluorine-fluorine interaction between the polyfluoroalkyl group and the hydrophilic interaction of the polyethylene glycol group, a nano-photosensitive micelle with an ultra-low CMC value is ultimately constructed. Boron dipyrromethene is induced by fluorine-fluorine interaction to undergo J-aggregation, causing the maximum absorption peak to red-shift to the near-infrared region, beneficial to the deep phototherapy of tumors.

Abstract: In a method of application programming interface (API) testing, a computing device obtains an API file transmitted by a user, parses the API file, and generates an API operation relationship graph and a test oracle. The computing device generates a first test case set based on the API operation relationship graph, and triggers a service node to execute a test case in the first test case set. The computing device obtains an API request initiated in a process of executing the test case in the first test case set and a corresponding API response, and provides the user with a matching status between the test oracle and the API request initiated in the process of executing the test case in the first test case set and the API response.

Abstract: A device for holding and rotating a plate shaped article comprises a group of fixed pins and a group of pivot pins arranged along the circumference of the movable base in a manner that each pivot pin opposites a fixed pin, and also comprises magnetic bodies positioned within and outside two opposing sides of the pivot pins. Each of the pivot pins can be driven to rotate around its pivot back and forth under the magnetic repulsive force between two adjacent magnetic bodies, so as to release or clamp the plate shaped article. The present invention has advantages of simple structure, convenient and reliable action control, controllable clamping force and good compatibility with various processing chambers.