Patents by Inventor DANDAN NIU

DANDAN NIU has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11957743
    Abstract: A Streptococcus suis (S. suis) vaccine is provided. For the S. suis vaccine, an antigen is a protein with an amino acid sequence shown in SEQ ID NO: 2. A preparation method of the S. suis vaccine is provided, including the following steps: mixing a white oil and aluminum stearate to obtain a white oil adjuvant; adding poly sorbate 80 to an aqueous solution of the protein with the amino acid sequence shown in SEQ ID NO: 2, and thoroughly mixing to obtain an antigen solution; and mixing the antigen solution with the white oil adjuvant according to a volume ratio of (0.5-1.5):2, and emulsifying to obtain the S. suis vaccine. An animal immunized with the S. suis vaccine of the present disclosure can effectively resist the attack of S. suis serotype 2, 3, and 31, with a vaccine protection rate as high as 100%.
    Type: Grant
    Filed: June 10, 2022
    Date of Patent: April 16, 2024
    Assignee: JIANGSU ACADEMY OF AGRICULTURAL SCIENCES
    Inventors: Qi Xiao, Xialing Zhao, Hongjie Fan, Xiaoguo Huang, Wenxian Qian, Libin Wen, Haodan Zhu, Yanxiu Ni, Junming Zhou, Dandan Wang, Jiaqiang Niu, Kongwang He
  • Publication number: 20240025756
    Abstract: The disclosure discloses a method for producing ?-calcium sulfate hemihydrate whiskers by using fermentation broth for producing lactic acid with a calcium salt method as a raw material and synchronously recovering a lactic acid monomer. The method comprises the following steps: 1) after fermentation of lactic acid is ended, heating fermentation broth; 2) stirring, and adding sulfuric acid for reaction; 3) after the reaction is ended, filtering and collecting a solid part, namely ?-calcium sulfite hemihydrate whiskers, and collecting a liquid part, namely a free lactic acid solution containing the lactic acid monomer; and 4) washing and drying the obtained ?-calcium sulfate hemihydrate whiskers to obtain a ?-calcium sulfate hemihydrate whisker finished product, filtering and concentrating the obtained free lactic acid solution to obtain a lactic acid crude product, and refining the lactic acid crude product to obtain a high-purity lactic acid monomer.
    Type: Application
    Filed: February 3, 2021
    Publication date: January 25, 2024
    Applicant: TIANJIN UNIVERSITY OF SCIENCE & TECHNOLOGY
    Inventors: Zhengxiang WANG, Dandan NIU, Kangming TIAN, Fuping LU, Chunli SHEN
  • Patent number: 11447760
    Abstract: A method of using lactase for generating galactooligosaccharide as well as the preparation and an application of the lactase are provided. Lactase (BglD305 derived from Bacillus circulans B2301 and BglD derived from Bacillus circulans ATCC 31382) molecules from two sources are taken as the basis for molecular evolution, so as to obtain new lactase enzyme molecules with high galactooligosaccharide synthesis efficiency and good expression performance. The high-producing strain lactase is further constructed, the lactase can be efficiently synthesized during the submerged fermentation, and the enzyme molecule is secreted into the culture medium, the high-activity enzyme preparation is directly prepared from the fermentation supernatant, and the lactase expression level can achieve 2208 U/mL. As the result, the fermentation manufacturing cost of lactase is reduced, the fermentation manufacturing process is simplified, and the quality of the lactase preparation is improved.
    Type: Grant
    Filed: September 15, 2021
    Date of Patent: September 20, 2022
    Assignee: Tianjin University of Science and Technology
    Inventors: Zhengxiang Wang, Dandan Niu, Kangming Tian
  • Publication number: 20220098563
    Abstract: A method of using lactase for generating galactooligosaccharide as well as the preparation and an application of the lactase are provided. Lactase (BglD305 derived from Bacillus circulans B2301 and BglD derived from Bacillus circulans ATCC 31382) molecules from two sources are taken as the basis for molecular evolution, so as to obtain new lactase enzyme molecules with high galactooligosaccharide synthesis efficiency and good expression performance. The high-producing strain lactase is further constructed, the lactase can be efficiently synthesized during the submerged fermentation, and the enzyme molecule is secreted into the culture medium, the high-activity enzyme preparation is directly prepared from the fermentation supernatant, and the lactase expression level can achieve 2208 U/mL. As the result, the fermentation manufacturing cost of lactase is reduced, the fermentation manufacturing process is simplified, and the quality of the lactase preparation is improved.
    Type: Application
    Filed: September 15, 2021
    Publication date: March 31, 2022
    Applicant: Tianjin University of Science and Technology
    Inventors: Zhengxiang WANG, Dandan NIU, Kangming TIAN
  • Patent number: 10472654
    Abstract: Disclosed are very high optically pure D- and L-lactic acid fermentation production strains and construction methods thereof and the method for preparing very high optically pure D- and L-lactic acids using the strains, wherein the deposit number of the D-lactic acid fermentation production strain is CGMCC No. 11059, and the deposit number of the L-lactic acid fermentation production strain is CGMCC No. 11060.
    Type: Grant
    Filed: November 20, 2017
    Date of Patent: November 12, 2019
    Assignee: Tianjin University of Science and Technology
    Inventors: Zhengxiang Wang, Kangming Tian, Dandan Niu, Fuping Lu
  • Publication number: 20180073045
    Abstract: Disclosed are very high optically pure D- and L-lactic acid fermentation production strains and construction methods thereof and the method for preparing very high optically pure D- and L-lactic acids using the strains, wherein the deposit number of the D-lactic acid fermentation production strain is CGMCC No. 11059, and the deposit number of the L-lactic acid fermentation production strain is CGMCC No. 11060.
    Type: Application
    Filed: November 20, 2017
    Publication date: March 15, 2018
    Inventors: ZHENGXIANG WANG, KANGMING TIAN, DANDAN NIU, FUPING LU