Patents by Inventor Dandan ZHANG

Dandan ZHANG has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240117043
    Abstract: The present disclosure provides a bispecific antibody including a binding domain that binds to CD112R and a binding domain that binds to TIGIT, and the binding domain that binds to CD112R includes: HCDR1, HCDR2 and HCDR3 of the amino acid sequence set forth in SEQ ID NO: 1, and/or LCDR1, LCDR2 and LCDR3 of the amino acid sequence set forth in SEQ ID NO: 2; and the HCDR1, HCDR2, HCDR3, LCDR1, LCDR2 and LCDR3 are defined according to the Kabat, IMGT, Chothia, AbM or Contact numbering system. The present disclosure further provides a polynucleotide encoding the antibody, an expression vector, a host cell and a method for expressing and purifying the antibody, a pharmaceutical composition including the antibody of the present disclosure, and use of the bispecific antibody for treating cancer.
    Type: Application
    Filed: August 4, 2023
    Publication date: April 11, 2024
    Applicants: SHANGHAI JUNSHI BIOSCIENCES CO., LTD., SUZHOU JUNMENG BIOSCIENCES CO., LTD.
    Inventors: Dandan LIU, Jinwei ZHOU, Yuehua ZHOU, Jing ZHANG, Sheng YAO, Hui FENG, Hui LIU, Hongchuan LIU, Li LI, Qiang ZHAO
  • Patent number: 11935216
    Abstract: A vision inspection system includes a sorting platform having an upper surface supporting parts for inspection. An inspection station is positioned adjacent the sorting platform including an imaging device to image the parts in a field of view. A vision inspection controller receives images from the imaging device. The vision inspection controller includes an image histogram tool to pre-process the images to improve contrast of the images by redistributing lightness values of the images based on adaptive histogram equalization processing to generate enhanced images. The vision inspection controller processes the enhanced images based on an image analysis model to determine inspection results for each of the parts. The vision inspection controller has an artificial intelligence learning module operated to customize and configure the image analysis model based on the enhanced images.
    Type: Grant
    Filed: July 28, 2020
    Date of Patent: March 19, 2024
    Assignees: Tyco Electronics (Shanghai) Co., Ltd., TE Connectivity Solutions GmbH
    Inventors: Roberto Francisco-Yi Lu, Sonny O. Osunkwo, Dandan Zhang, Jiankun Zhou, Lei Zhou
  • Patent number: 11891201
    Abstract: A cable bundle taping device adapted to wind a tape on a coiled cable bundle includes a support frame, a conveying device mounted on the support frame and adapted to convey the tape to a standby position, a first driving wheel rotatably mounted on the support frame and having a slot extending radially inward from an outer edge of the first driving wheel, and a tape binding mechanism arranged on a side of at least one sidewall of the first driving wheel near a bottom of the slot and opposite to the tape in the standby position. The coiled cable bundle is bonded to an end of the tape at the standby position and pushed to the bottom of the slot. The tape is wound on the coiled cable bundle by rotating the tape binding mechanism under driving of the first driving wheel.
    Type: Grant
    Filed: October 13, 2020
    Date of Patent: February 6, 2024
    Assignees: Tyco Electronics (Shanghai) Co., Ltd., TE Connectivity Solutions GmbH, Kunshan League Automechanism Co., Ltd.
    Inventors: An Yang, Lvhai Hu, Dandan Zhang, Roberto Francisco-Yi Lu, Jian Cao, Yun Liu, Yuting He, Haidong Wu, Hui Xiao
  • Patent number: 11891248
    Abstract: An article support device has a pair of support platforms arranged symmetrically and opposite to each other. Each of the support platforms includes a support frame, a support plate disposed on a top of the support frame and having a horizontal support top surface, and at least one positioning block installed on the horizontal support top surface. The horizontal support top surfaces of the support plates are located at a same height position. The article is supported on the horizontal support top surfaces and positioned between the positioning blocks on the support plates. An accommodation space is defined between the support plates and the support frames, and an automated guided vehicle moves into the accommodation space. An article carried on the article support device is loadable onto the automatic guided vehicle or the article carried on the automatic guided vehicle is unloadable onto the article support device.
    Type: Grant
    Filed: November 12, 2020
    Date of Patent: February 6, 2024
    Assignees: Tyco Electronics (Shanghai) Co., Ltd., TE Connectivity Solutions GmbH, Kunshan Sanxin Plastic Industry Co., Ltd.
    Inventors: Yingcong Deng, Ming Ni, Lei Yang, Dong Xu, Dandan Zhang, Fengchun Xie, Huabin Du, Roberto Francisco-Yi Lu, Yangming Wen, Ge Chen
  • Publication number: 20240034991
    Abstract: In a method for efficiently inducing reprogramming of human cells into neuronal cells, a concentration of cAMP is increased or an expression of PKA and CREB is up-regulated or an expression of AMPK, ALK2, ALK3, P38, and JNK is inhibited by a single small molecule compound or gene knockout or gene overexpression. In the present disclosure, the induction small molecule compound is single and safe, and has a short induction time, high induction efficiency, definite induction sites and genes, and clear molecular regulation mechanism. The small molecule compound can be applied to the clinical treatment of human neurodegenerative diseases, providing a safer and more efficient treatment method for the neurodegenerative diseases. Since neuronal cells cannot divide and proliferate, the method induces fibroblasts and astrocytes that can divide and proliferate in vitro and in vivo, to continuously obtain a large number of induced neuronal cells in vitro and in vivo.
    Type: Application
    Filed: July 27, 2022
    Publication date: February 1, 2024
    Applicants: GUANGXI UNIVERSITY, Guangxi Benpeng Biotechnology Co., Ltd.
    Inventors: Ben HUANG, Guodong WANG, Dandan ZHANG, Quanhui LIU, Yulian WU, Danwei LV, Jigang HU, Xiaolian XIE
  • Patent number: 11769978
    Abstract: An assembly system includes a robot, a first gripper mounted on the robot, the first gripper gripping a first housing, and a first clamping device clamping a cable and a contact connected to an end of the cable. The robot moves the first gripper and assembles the first housing gripped by the first gripper onto the contact held by the first clamping device.
    Type: Grant
    Filed: December 3, 2019
    Date of Patent: September 26, 2023
    Assignees: TE Connectivity Solutions GmbH Tyco, Electronics (Shanghai) Co., Ltd., Kunshan League Automechanism Co., Ltd.
    Inventors: Yingcong Deng, Dandan Zhang, Lvhai Hu, An Yang, Jian Cao, Yun Liu, Roberto Franciso-Yi Lu, Yuting He, Haidong Wu, Hui Xiao
  • Patent number: 11753265
    Abstract: A stamping strip reel replacing system includes an autonomous mobile robot and an automatic guide vehicle. The autonomous mobile robot is adapted to autonomously move to a position where a reel driving shaft for mounting the reel is located, and includes a grabbing tool for grabbing the reel. The automatic guide vehicle moves together with the autonomous mobile robot, and carries an empty reel wound with no stamping strip. The autonomous mobile robot is further adapted to unload a full reel wound with the stamping strip from the reel driving shaft and place the unloaded full reel onto the automatic guide vehicle by operating the grabbing tool. The autonomous mobile robot is further adapted to grab the empty reel from the automatic guide vehicle and mount the grabbed empty reel onto the reel driving shaft by operating the grabbing tool.
    Type: Grant
    Filed: May 14, 2021
    Date of Patent: September 12, 2023
    Assignees: TE Connectivity Germany GmbH, Tyco Electronics (Shanghai) Co., Ltd., TE Connectivity Solutions GmbH
    Inventors: Yingcong Deng, Dandan Zhang, Lvhai Hu, Fengchun Xie, Roberto Francisco-Yi Lu, Josef Sinder, Zongjie Tao, Xiaochen Yu, Swapnilsinh Solanki, Jiankun Zhou, Tim Darr
  • Patent number: 11749957
    Abstract: A cable straightening device includes a plurality of cable straightening units connected in series. Each of the cable straightening units includes a base, a pair of rows of rollers mounted on the base and cooperating with each other to define a pressing path extending in a row direction, and a mounting frame disposed on at least one end of a pair of opposite ends of the base in the row direction. A cable is pressed by the rows of rollers while passing through the pressing path. Any two adjacent cable straightening units are assembled together at the mounting frame of each so that center lines of the pressing paths of two adjacent cable straightening units are aligned with each other.
    Type: Grant
    Filed: November 2, 2020
    Date of Patent: September 5, 2023
    Assignees: Tyco Electronics (Shanghai) Co., Ltd., TE Connectivity Solutions GmbH
    Inventors: An Yang, Lvhai Hu, Dandan Zhang, Roberto Francisco-Yi Lu, Jian Cao, Yun Liu
  • Publication number: 20230237636
    Abstract: A vision inspection system includes a vision inspection controller receiving images form an imaging device. The vision inspection controller includes a binary classification tool and a multi-classification tool. The vision inspection controller processes each of the images through the binary classification tool to detect for the defects to determine primary inspection results including a PASS result if no defects are detected and a FAIL result if defects are detected. The vision inspection controller processes each of the images associated with the FAIL result through the multi-classification tool to determine secondary inspection results including identification of a type of defect. The vision inspection system may include a display configured to display the primary and secondary inspection results to an operator.
    Type: Application
    Filed: February 24, 2022
    Publication date: July 27, 2023
    Inventors: Sonny O. Osunkwo, Lei Zhou, Roberto Francisco-Yi Lu, Dandan Zhang, Jiankun Zhou, Angel Alberto Slistan, Tianyi Gao
  • Patent number: 11707755
    Abstract: A painting system includes a conveying mechanism adapted to convey a workpiece to be painted to a painting station, a holding and rotating mechanism mounted at the painting station and adapted to hold and rotate the workpiece, and a robot having a nozzle adapted to spray a paint on the workpiece held by the holding and rotating mechanism. The robot is configured to spray the paint onto the workpiece while the holding and rotating mechanism rotates the workpiece, spraying a layer of the paint on an outer surface of the workpiece.
    Type: Grant
    Filed: August 23, 2021
    Date of Patent: July 25, 2023
    Assignees: TE Connectivity Solutions GmbH, Kunshan League Automechanism Co., Ltd., Tyco Electronics (Shanghai) Co., Ltd.
    Inventors: Rong Zhang, Roberto Francisco-Yi Lu, Dandan Zhang, Lvhai Hu, Haidong Wu, Yuting He
  • Patent number: 11673176
    Abstract: A servo-driven Z-shape bending device includes a base, a Z-shape bending module disposed on the base, a servo-drive mechanism disposed on the base, and a terminal feeding mechanism disposed on the base. The Z-shape bending module is configured to perform a bending operation on a terminal to be bent to form a Z-shaped terminal. The servo-drive mechanism is configured to servo-drive the Z-shape bending module to perform the bending operation. The terminal feeding mechanism is configured to feed the terminal to be bent to the Z-shape bending module.
    Type: Grant
    Filed: November 19, 2020
    Date of Patent: June 13, 2023
    Assignees: TE Connectivity Solutions GmbH, Tyco Electronics (Shanghai) Co., Ltd., Kunshan Leagure Automechanism Co., Ltd., Tyco Electronics Polska Sp. z.o.o
    Inventors: Fengchun Xie, Jaroslaw Kowalski, Andrzej Przybylski, Dandan Zhang, Lvhai Hu, Yingcong Deng, Jian Cao, Radoslaw Mrozik, Roberto Francisco-Yi Lu, Haidong Wu
  • Patent number: 11637407
    Abstract: A welding system comprises a welding module and a moving module adapted to move the welding module to a predetermined welding position. The welding module includes a guiding device and a welding tool. The guiding device has a plurality of tubular guiding heads arranged in a row, ends of the plurality of tubular guiding heads are disposed close to joints of a plurality of cables so as to guide a plurality of welding wires to the joints of the plurality of cables. The welding tool has a plurality of tooth-shaped welding heads arranged in a row, ends of the plurality of tooth-shaped welding heads are disposed close to the joints of the plurality of cables and configured to simultaneously heat the plurality of welding wires guided to the joints of the plurality of cables, so as to simultaneously weld the joints of the plurality of cables onto a circuit board.
    Type: Grant
    Filed: August 6, 2019
    Date of Patent: April 25, 2023
    Assignees: TE Connectivity Solutions GmbH, Tyco Electronics (Shanghai) Co. Ltd.
    Inventors: Changjun Wang, Dandan Zhang, Roberto Francisco-Yi Lu, Lvhai Hu, Yun Liu, Fengchun Xie
  • Patent number: 11597623
    Abstract: A cable tension control device includes a pair of first active rollers clamping a cable therebetween, a first driver driving the first active rollers, a pair of second active rollers clamping the cable therebetween at an upstream position from the first active rollers, a second driver driving the second active rollers, a floating roller arranged between the first active rollers and the second active rollers and exerting a pushing force on the cable, and an actuator driving the floating roller to move vertically to adjust the pushing force exerted on the cable. A tension force applied on the cable is controlled to be equal to a predetermined tension force by controlling the pushing force and by controlling a speed difference between a first speed at which the first active rollers convey the cable forward and a second speed at which the second active rollers convey the cable forward.
    Type: Grant
    Filed: July 29, 2020
    Date of Patent: March 7, 2023
    Assignees: TE Connectivity Solutions GmbH, TE Connectivity Co. Ltd.
    Inventors: Zongjie Tao, Dandan Zhang, Roberto Francisco-Yi Lu, Yingcong Deng, Zhonghua Xu
  • Publication number: 20230066648
    Abstract: The present disclosure provides a method for inducing transdifferentiation of somatic cells into mammary epithelial cells in vitro using a small molecule compound. The method includes: inhibiting an expression of TGFbeta R1 and related sites thereof, to induce the transdifferentiation of the somatic cells into the mammary epithelial cells in vitro. The present disclosure fills a gap in the technology of inducing the transdifferentiation of fibroblasts to the mammary epithelial cells using the small molecule compound; the present disclosure also provides a research platform for in vitro researches on a mammary gland bioreactor, mammary gland development and differentiation, breast cancer, and transdifferentiation of the fibroblasts into other types of functional cells.
    Type: Application
    Filed: June 30, 2020
    Publication date: March 2, 2023
    Applicants: GUANGXI UNIVERSITY, Guangxi Benpeng Biotechnology Co., Ltd.
    Inventors: Ben HUANG, Dandan ZHANG, Sheng YE, Shaoqian ZHU, Quanhui LIU, Liangshan QIN, Deshun SHI, Jigang HU, Xiaolian XIE
  • Publication number: 20230049359
    Abstract: The present application discloses an identification circuit for a power-line carrier signal. During signal transmission on a power line, the amplitude change and duration of a voltage signal on the power line are identified and then decoded into corresponding data, so as to reduce dependency on a power supply voltage during signal identification, and prevent the signal identification rate from decreasing as a result of an increase in the transmission distance, thereby reducing requirements for a system power supply.
    Type: Application
    Filed: December 31, 2019
    Publication date: February 16, 2023
    Inventors: Yungen ZOU, Yuling LU, Shicheng QIAO, Ronghuai CAI, Mengbang CHEN, Dandan ZHANG, Jinwei CAO
  • Publication number: 20230053085
    Abstract: A part inspection system includes a vision device configured to image a part being inspected and generate a digital image of the part. The system includes a part inspection module communicatively coupled to the vision device and receives the digital image of the part as an input image. The part inspection module includes a defect detection model. The defect detection model includes a template image. The defect detection model compares the input image to the template image to identify defects. The defect detection model generates an output image. The defect detection model configured to overlay defect identifiers on the output image at the identified defect locations, if any.
    Type: Application
    Filed: December 21, 2021
    Publication date: February 16, 2023
    Inventors: Sonny O. Osunkwo, Lei Zhou, Jiankun Zhou, Roberto Francisco-Yi Lu, Dandan Zhang, Zhonghua Xu, Avil Saunshi, Rajesh RK, Andrew Riordan, Viraat Das, Krithik Rao, Kuruvilla Thomas Renji, Dwivedi Jaya
  • Publication number: 20220411430
    Abstract: The disclosure relates to a series of substituted imidazolecarboxamide compounds of formula I as BTK (Bruton's Tyrosine Kinase) inhibitors, and the methods of using the same for the treatment of autoimmune disease, inflammatory disease, cancer and potentially allergies.
    Type: Application
    Filed: December 4, 2020
    Publication date: December 29, 2022
    Applicant: Henan Zhiwei Biomedicine Co., Ltd.
    Inventors: Yuqin Jiang, Qingjie Ding, Chunhua Ma, Guiqing Xu, Dandan Zhang, Yang Li, Pengfei Li, Wei Li, Shouning Yang, Xin Shi, Peipei Shi
  • Patent number: 11471967
    Abstract: A fixation apparatus includes a base, a wire fixing device mounted on the base, and a pressing device mounted on the base. The wire fixing device positions and fixes a wire on a circuit board and includes a fixing frame mounted on the base and a moving unit received in a receiving chamber of the fixing frame. The fixing frame has a first positioning groove. The moving unit is movable between a clamping position and a release position and has a second positioning groove coupled with the first positioning groove. The wire is inserted into a wire insertion hole in the circuit board between the first positioning groove and the second positioning groove when the mobile unit is moved to the release position. The wire is clamped and fixed between the first positioning groove and the second positioning groove when the moving unit is moved to the clamping position.
    Type: Grant
    Filed: December 13, 2019
    Date of Patent: October 18, 2022
    Assignees: Tyco Electronics (Shanghai) Co. Ltd., Measurement Sepcialties (China) Ltd., Shenzhen Ami Technology Co. Ltd.
    Inventors: Yingcong Deng, Jeffrey Rochette, Qiyu Cai, Yang Zhou, Wenzhao Liao, Yumin Lan, Yanbing Fu, Yun Liu, Dandan Zhang, Qinglong Zeng
  • Publication number: 20220318982
    Abstract: A part inspection system is provided and includes a vision device configured to image a part is inspected and generate a digital image of the part. The part inspection system includes a part inspection module coupled to the vision device and receiving the digital image of the part. The part inspection module includes a memory for storing a neural network architecture having a plurality of convolutional layers, a plurality of pooling layers disposed after different convolutional layers and spaced apart from each other, at least one random noise generation layer downstream of the convolutional layers and the pooling layers, and an output layer. The part inspection module includes a processor configured to analyze the digital image through the layers of the neural network architecture to output one of a defective output or a non-defective output based on the image analysis of the digital image through the neural network architecture.
    Type: Application
    Filed: May 12, 2021
    Publication date: October 6, 2022
    Inventors: Sonny O. Osunkwo, Roberto Francisco-Yi Lu, Jiankun Zhou, Lei Zhou, Angel Alberto Slistan, Dandan Zhang
  • Patent number: 11403743
    Abstract: A cable detection apparatus includes a cable support and a vision system. The vision system has a camera device rotatable about an axis parallel to an axial direction of a cable to be detected, so as to capture an image of the cable, and an optical element rotated synchronously with the camera device. The optical element transmits the image of the cable to the camera device by changing an optical path of the image.
    Type: Grant
    Filed: November 27, 2019
    Date of Patent: August 2, 2022
    Assignees: Tyco Electronics (Shanghai) Co. Ltd., TE Connectivity Corporation, Kunshan League Automechanism Co.. Ltd.
    Inventors: Hongtao Liu, Dandan Zhang, Roberto Francisco-Yi Lu, An Yang, Lvhai Hu, Yuting He