Patents by Inventor Dane S. Worley

Dane S. Worley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nogo receptor antagonists
    Patent number: 8030456
    Abstract: Disclosed are immunogenic Nogo receptor-1 polypeptides, Nogo receptor-1 antibodies, antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof and nucleic acids encoding the same. Also disclosed are compositions comprising, and methods for making and using, such Nogo receptor antibodies, antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof and nucleic acids encoding the same.
    Type: Grant
    Filed: December 15, 2008
    Date of Patent: October 4, 2011
    Assignees: Yale University, Biogen Idec MA Inc.
    Inventors: Daniel H. S. Lee, R. Blake Pepinsky, Weiwei Li, Jane K. Relton, Dane S. Worley, Stephen M. Strittmatter, Dinah W. Y. Sah, Sylvia A. Rabacchi
  • NOGO Receptor Antagonists
    Publication number: 20090215691
    Abstract: Disclosed are immunogenic Nogo receptor-1 polypeptides, Nogo receptor-1 antibodies, antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof and nucleic acids encoding the same. Also disclosed are compositions comprising, and methods for making and using, such Nogo receptor antibodies, antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof and nucleic acids encoding the same.
    Type: Application
    Filed: December 15, 2008
    Publication date: August 27, 2009
    Applicants: Yale University, Biogen Idec MA Inc.
    Inventors: Daniel H.S. Lee, R. Blake Pepinsky, Weiwei Li, Jane K. Relton, Dane S. Worley, Stephen M. Strittmatter, Dinah W.Y. Sah, Sylvia A. Rabacchi
  • ANTI-GFRALPHA3 ANTIBODIES
    Publication number: 20090202562
    Abstract: Antibodies and antibody fragments that bind to the receptor GFRalpha3 and inhibit formation of a Neublastin-GFRalpha3-Ret ternary complex are disclosed. Also disclosed are methods of using the antibodies and antibody fragments to inhibit phosphorylation of Ret in a cell and treat disorders and in a subject.
    Type: Application
    Filed: June 16, 2006
    Publication date: August 13, 2009
    Applicant: BIOGEN IDEC MA INC.
    Inventors: Dane S. Worley, Dinah Wen-Yee Sah, Katherine W. Seamans
  • Nogo receptor antagonists
    Patent number: 7465705
    Abstract: Disclosed are immunogenic Nogo receptor-1 polypeptides, Nogo receptor-1 antibodies, antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof and nucleic acids encoding the same. Also disclosed are compositions comprising, and methods for making and using, such Nogo receptor antibodies, antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof and nucleic acids encoding the same.
    Type: Grant
    Filed: February 10, 2005
    Date of Patent: December 16, 2008
    Assignees: Yale University, Biogen Idec MA Inc.
    Inventors: Daniel H. S. Lee, R. Blake Pepinsky, Weiwei Li, Jane K. Relton, Dane S. Worley, Stephen M. Strittmatter, Dinah W. Y. Sah, Sylvia A. Rabacchi
  • Nogo Receptor Antagonists
    Publication number: 20080274112
    Abstract: Disclosed are immunogenic Nogo receptor-1 polypeptides, Nogo receptor-1 antibodies, antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof and nucleic acids encoding the same. Also disclosed are compositions comprising, and methods for making and using, such Nogo receptor antibodies, antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof and nucleic acids encoding the same.
    Type: Application
    Filed: January 30, 2004
    Publication date: November 6, 2008
    Inventors: Daniel H.S. Lee, R. Blake Pepinsky, Weiwei Li, Sylvia A. Rabacchi, Jane K. Relton, Dane S. Worley, Stephen M. Strittmatter, Dinah W.Y. Sah
  • Antibodies to Ret and RetL3
    Patent number: 6861509
    Abstract: Nucleotide and amino acid sequences are provided for compounds which promote tissue growth, as well as methods for modulating tissue growth, for imaging tissues and organs, and for treating patients.
    Type: Grant
    Filed: January 21, 2000
    Date of Patent: March 1, 2005
    Assignee: Biogen, Inc.
    Inventors: Michele Sanicola-Nadel, Catherine Hession, Richard L. Cate, Dane S. Worley
  • Ret ligand (RetL) for stimulating neutral and renal growth
    Patent number: 6677135
    Abstract: Nucleotide and amino acid sequences are provided for compounds which promote tissue growth, as well as methods for modulating tissue growth, for imaging tissues and organs, and for treating patients. Isolated nucleic acid and amino acid sequences for Ret ligands are disclosed. Ret ligands encoded by the isolated nucleic acid sequences of the invention have a hydrophobic N-terminal signal sequence, a hydrophobic C-terminal sequence and a phosphatidylinositol glycan linkage motif. Vectors and host cells that include Ret ligands encoded by the isolated nucleic acid sequences of the invention are also disclosed.
    Type: Grant
    Filed: November 6, 1998
    Date of Patent: January 13, 2004
    Assignee: Biogen, Inc.
    Inventors: Michele Sanicola-Nadel, Catherine Hession, Richard L. Cate, Dane S. Worley