Patents by Inventor Daneil Lee SEVERANCE

Daneil Lee SEVERANCE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • O-LINKED THIADIAZOLYL COMPOUNDS AS DNA POLYMERASE THETA INHIBITORS
    Publication number: 20240287080
    Abstract: Disclosed herein are certain thiadiazolyl derivatives Formula (I): that inhibit DNA Polymerase Theta (Pol?) activity, in particular inhibit Pol? activity by inhibiting ATP dependent helicase domain activity of Pol?. Also, disclosed are pharmaceutical compositions comprising such compounds and methods of treating and/or preventing diseases treatable by inhibition of Pol? such as cancer, including homologous recombination (HR) deficient cancers.
    Type: Application
    Filed: June 9, 2022
    Publication date: August 29, 2024
    Inventors: Paul A. BARSANTI, Kevin J. DUFFY, Brian G. LAWHORN, Firoz Ali JAIPURI, Daneil Lee SEVERANCE, Chenbo WANG, Nicholas David ADAMS, Janos BOTYANSZKI, Michael G. DARCY, Terence J. KIESOW, John J. MCATEE, Cuthbert MARTYR, Alexander BUTTRAGO SANTANILLA, Xinrong TIAN