Abstract: The present disclosure relates to a method for loading a dimeric CD24 into an HEK293 cell exosome with ADAM10 gene knocked out. By means of loading a dimeric CD24 and/or ApoE protein into an HEK293 cell exosome with ADAM10 gene knocked out, the efficacy is improved over 1000 times compared with that of a free CD24-Fc fusion protein and ApoE protein. Meanwhile, a MyD88 inhibitor polypeptide is loaded into the exosome, so that the inhibition efficacy of the exosome on an inherent immune inflammatory response is improved. After the CD24-exosome, the ApoE-exosome, or the CD24-ApoE-exosome loaded with the described inhibitor polypeptide is phagocytosed and removed by an immune cell, the MyD88 inhibitor polypeptide can be released in the cell, the inflammation inhibition efficacy is continuously exerted, and the duration of drug's action is effectively prolonged.

Abstract: A display substrate includes a base substrate, a pixel circuit layer, a first planarization layer, at least one transparent conductive layer, and a plurality of first light-emitting elements. The base substrate includes a first display region and a second display region, wherein the first display region at least partially surrounds the second display region. The pixel circuit layer is located in the first display region, and includes a plurality of pixel circuits, wherein the plurality of pixel circuits include a plurality of first pixel circuits. A plurality of first light-emitting elements are located in the second display region. The first planarization layer is located on a side of the pixel circuit layer away from the base substrate, and is located in the first display region and the second display region.

Abstract: The embodiments of this application provide a secondary battery, and a battery module, a battery pack and an apparatus including the same. Specifically, this application provides a secondary battery, which includes a negative electrode plate. The negative electrode plate includes a negative electrode current collector and a negative electrode film disposed on at least one surface of the negative electrode current collector. The negative electrode film includes a negative electrode active material, a conductive agent, and a binder. The negative electrode active material includes SiOx (0<x<2) and graphite. An average particle diameter Dv50 of the negative electrode active material is from 8 ?m to 14 ?m. The conductive agent includes carbon nanotubes whose aspect ratio is greater than or equal to 2500:1. The secondary battery can have both good rate performance and cycle performance under the premise of a relatively high energy density.

Abstract: The embodiments of this application provide a secondary battery, and a battery module, a battery pack and an apparatus including the same. Specifically, this application provides a secondary battery, which includes a negative electrode plate. The negative electrode plate includes a negative electrode current collector and a negative electrode film disposed on at least one surface of the negative electrode current collector. The negative electrode film includes a negative electrode active material, a conductive agent, and a binder. The negative electrode active material includes SiOx (0<x<2) and graphite. An average particle diameter Dv50 of the negative electrode active material is from 8 ?m to 14 ?m. The conductive agent includes carbon nanotubes whose aspect ratio is greater than or equal to 2500:1. The secondary battery can have both good rate performance and cycle performance under the premise of a relatively high energy density.

Abstract: Provided are a human-induced pluripotent stem cell overexpressing TLX and use thereof. By enabling a human-induced pluripotent stem cell (hiPSC) to overexpress TLX or a truncation thereof, the self-driven differentiation of hiPSC into NSC is achieved. By employing this solution, not only the differentiation of hiPSC into NSC is accelerated, but also long-term stable in-vitro passaging of NSC is achieved, so that donor cells are provided for the treatment of nervous system diseases, cell therapy, and the like, and the obtained NSC exosome has good biological activity.

Abstract: A pixel circuit comprises a drive sub-circuit (101), writing sub-circuit (102), reset sub-circuit (103), voltage stabilizing sub-circuit (104), storage sub-circuit (105) and light emitting element. The drive sub-circuit is configured to provide a driving current to the light emitting element under control of signals of a first node (N1) and a second node (N2); the writing sub-circuit is configured to write a signal from a data signal terminal (Data) to N2 under control of signal of a scan signal terminal (Gate); the storage sub-circuit is configured to store a voltage of N1; the voltage stabilizing sub-circuit is configured to stabilize a voltage of an anode terminal of light emitting element through signal of a voltage stabilizing signal terminal (V1); the reset sub-circuit is configured to reset anode terminal of light emitting element under control of signal of Gate and reset N1 under control of signal of a reset control signal terminal (Reset).

Abstract: A pixel driving circuit, a driving method thereof and a display panel are provided. The pixel driving circuit includes a driving transistor, a capacitor having two terminals connected to a first power terminal and a gate electrode of the driving transistor, and a light emitting device. The pixel driving circuit includes: a reset module; a data writing module; a threshold compensation module including a compensation transistor configured to electrically connect second and gate electrodes of the driving transistor together in the data writing phase; a light emitting control module including a first gating transistor configured to electrically connect the second electrode of the driving transistor and the light emitting device in the reset phase and disconnect the second electrode from the light emitting device in the data writing phase. The compensation transistor and the first gating transistor are oxide transistors, and the driving transistor is a low-temperature polysilicon transistor.

Abstract: A pixel circuit comprises a drive sub-circuit (101), writing sub-circuit (102), reset sub-circuit (103), voltage stabilizing sub-circuit (104), storage sub-circuit (105) and light emitting element. The drive sub-circuit is configured to provide a driving current to the light emitting element under control of signals of a first node (N1) and a second node (N2); the writing sub-circuit is configured to write a signal from a data signal terminal (Data) to N2 under control of signal of a scan signal terminal (Gate); the storage sub-circuit is configured to store a voltage of N1; the voltage stabilizing sub-circuit is configured to stabilize a voltage of an anode terminal of light emitting element through signal of a voltage stabilizing signal terminal (V1); the reset sub-circuit is configured to reset anode terminal of light emitting element under control of signal of Gate and reset N1 under control of signal of a reset control signal terminal (Reset).

Abstract: A display substrate includes a base substrate, a pixel circuit layer, a first planarization layer, at least one transparent conductive layer, and a plurality of first light-emitting elements. The base substrate includes a first display region and a second display region, wherein the first display region at least partially surrounds the second display region. The pixel circuit layer is located in the first display region, and includes a plurality of pixel circuits, wherein the plurality of pixel circuits include a plurality of first pixel circuits. A plurality of first light-emitting elements are located in the second display region. The first planarization layer is located on a side of the pixel circuit layer away from the base substrate, and is located in the first display region and the second display region.

Abstract: A battery swap method includes obtaining impedance parameters of battery packs that include a reference battery pack and a plurality of candidate battery packs, obtaining impedance differences between the reference battery pack and the plurality of candidate battery packs based on the impedance parameters, and selecting M target battery packs based on the impedance differences. M is a positive integer and the candidate battery packs include the target battery packs. The method further includes setting the target battery packs and the reference battery pack as swapped-in battery packs.

Abstract: A pixel driving circuit, a driving method thereof and a display panel are provided. The pixel driving circuit includes a driving transistor, a capacitor having two terminals connected to a first power terminal and a gate electrode of the driving transistor, and a light emitting device. The pixel driving circuit includes: a reset module; a data writing module; a threshold compensation module including a compensation transistor configured to electrically connect second and gate electrodes of the driving transistor together in the data writing phase; a light emitting control module including a first gating transistor configured to electrically connect the second electrode of the driving transistor and the light emitting device in the reset phase and disconnect the second electrode from the light emitting device in the data writing phase. The compensation transistor and the first gating transistor are oxide transistors, and the driving transistor is a low-temperature polysilicon transistor.

Abstract: The embodiments of this application provide a secondary battery, and a battery module, a battery pack and an apparatus including the same. Specifically, this application provides a secondary battery, which includes a negative electrode plate. The negative electrode plate includes a negative electrode current collector and a negative electrode film disposed on at least one surface of the negative electrode current collector. The negative electrode film includes a negative electrode active material, a conductive agent, and a binder. The negative electrode active material includes SiOx (0<x<2) and graphite. An average particle diameter Dv50 of the negative electrode active material is from 8 ?m to 14 ?m. The conductive agent includes carbon nanotubes whose aspect ratio is greater than or equal to 2500:1. The secondary battery can have both good rate performance and cycle performance under the premise of a relatively high energy density.