Patents by Inventor Dangshe Ma

Dangshe Ma has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Radiolabeled MET binding proteins for immuno-PET imaging and methods of use thereof
    Patent number: 11896682
    Abstract: Radiolabeled anti-MET antibodies and MET×MET bispecific antibodies and their use in immuno-PET imaging are provided herein. Included are methods of detecting the presence of MET proteins in a subject or sample and methods of monitoring efficacy of treatment of a Met expressing tumor.
    Type: Grant
    Filed: September 15, 2020
    Date of Patent: February 13, 2024
    Assignee: REGENERON PHARMACEUTICALS, INC.
    Inventors: Marcus Kelly, Dangshe Ma, William Olson
  • RADIOLABELED ANTI-LAG3 ANTIBODIES FOR IMMUNO-PET IMAGING
    Publication number: 20230270894
    Abstract: Radiolabeled anti-LAG3 antibodies and their use in immuno-PET imaging are provided herein. Included are methods of detecting the presence of LAG3 proteins in a patient or sample.
    Type: Application
    Filed: October 25, 2022
    Publication date: August 31, 2023
    Inventors: Marcus Kelly, Dangshe Ma, William Olson, Gavin Thurston, Richard Tavare
  • ANTI-CD8 ANTIBODIES AND USES THEREOF
    Publication number: 20230159639
    Abstract: Anti-CD8 antibodies, radiolabeled anti-CD8 antibodies, fluorescently labeled anti-CD8 antibodies and their use in imaging are provided herein. Included are methods of detecting the presence of CD8 proteins in a subject or sample.
    Type: Application
    Filed: October 26, 2022
    Publication date: May 25, 2023
    Inventors: Jason T. Giurleo, Dangshe Ma, William Olson, Gavin Thurston, Richard Tavare
  • Anti-CD8 antibodies and uses thereof
    Patent number: 11525001
    Abstract: Anti-CD8 antibodies, radiolabeled anti-CD8 antibodies, fluorescently labeled anti-CD8 antibodies and their use in imaging are provided herein. Included are methods of detecting the presence of CD8 proteins in a subject or sample.
    Type: Grant
    Filed: June 26, 2020
    Date of Patent: December 13, 2022
    Assignee: Regeneron Pharmaceuticals, Inc.
    Inventors: Jason T. Giurleo, Dangshe Ma, William Olson, Richard Tavare, Gavin Thurston
  • Radiolabeled anti-LAG3 antibodies for immuno-PET imaging
    Patent number: 11511001
    Abstract: Radiolabeled anti-LAG3 antibodies and their use in immuno-PET imaging are provided herein. Included are methods of detecting the presence of LAG3 proteins in a patient or sample.
    Type: Grant
    Filed: December 18, 2020
    Date of Patent: November 29, 2022
    Assignee: Regeneron Pharmaceuticals, Inc.
    Inventors: Marcus Kelly, Dangshe Ma, William Olson, Gavin Thurston, Richard Tavare
  • RADIOLABELED ANTI-PD-L1 ANTIBODIES FOR IMMUNO-PET IMAGING
    Publication number: 20220184241
    Abstract: Radiolabeled anti-PD-L1 antibodies and their use in immuno-PET imaging are provided herein. Included are methods of detecting the presence of PD-L1 proteins in a patient or sample.
    Type: Application
    Filed: December 22, 2021
    Publication date: June 16, 2022
    Inventors: Marcus Kelly, Dangshe Ma, William Olson, Gavin Thurston
  • ANTI-CD8 ANTIBODIES AND USES THEREOF
    Publication number: 20210147542
    Abstract: Anti-CD8 antibodies, radiolabeled anti-CD8 antibodies, fluorescently labeled anti-CD8 antibodies and their use in imaging are provided herein. Included are methods of detecting the presence of CD8 proteins in a subject or sample.
    Type: Application
    Filed: June 26, 2020
    Publication date: May 20, 2021
    Inventors: Jason T. Giurleo, Dangshe Ma, William Olson, Richard Tavare, Gavin Thurston
  • RADIOLABELED ANTI-LAG3 ANTIBODIES FOR IMMUNO-PET IMAGING
    Publication number: 20210138096
    Abstract: Radiolabeled anti-LAG3 antibodies and their use in immuno-PET imaging are provided herein. Included are methods of detecting the presence of LAG3 proteins in a patient or sample.
    Type: Application
    Filed: December 18, 2020
    Publication date: May 13, 2021
    Inventors: Marcus Kelly, Dangshe Ma, William Olson, Gavin Thurston, Richard Tavare
  • RADIOLABELED MET BINDING PROTEINS FOR IMMUNO-PET IMAGING
    Publication number: 20210077638
    Abstract: Radiolabeled anti-MET antibodies and MET×MET bispecific antibodies and their use in immuno-PET imaging are provided herein. Included are methods of detecting the presence of MET proteins in a subject or sample and methods of monitoring efficacy of treatment of a Met expressing tumor.
    Type: Application
    Filed: September 15, 2020
    Publication date: March 18, 2021
    Inventors: Marcus Kelly, Dangshe Ma, William Olson
  • Radiolabeled anti-LAG3 antibodies for immuno-PET imaging
    Patent number: 10905784
    Abstract: Radiolabeled anti-LAG3 antibodies and their use in immuno-PET imaging are provided herein. Included are methods of detecting the presence of LAG3 proteins in a patient or sample.
    Type: Grant
    Filed: February 9, 2018
    Date of Patent: February 2, 2021
    Assignee: REGENERON PHARMACEUTICALS, INC.
    Inventors: Marcus Kelly, Dangshe Ma, William Olson, Richard Tavare, Gavin Thurston
  • PSMA ANTIBODY-DRUG CONJUGATES
    Publication number: 20210023094
    Abstract: This invention relates generally to antibody-drug conjugates (ADCs). In particular, the invention relates to ADCs which comprise an antibody or antigen-binding fragment thereof which binds to prostate-specific membrane antigen (PSMA) and is conjugated to monomethylauristatin norephedrine or monomethylauristatin phenylalanine. The antibody-drug conjugate has a PC-3™ cell to C4-2 or LNCaP™ cell selectivity of at least 250. The invention also relates, in part, to compositions of and methods of using the ADCs. The methods provided include, for example, methods for treating a PSMA-mediated disease.
    Type: Application
    Filed: July 6, 2020
    Publication date: January 28, 2021
    Applicant: PSMA Development Company, LLC
    Inventors: Dangshe Ma, Paul J. Maddon, William C. Olson, Svetlana O. Doronina, Brian E. Toki, Peter D. Senter
  • SITE SPECIFIC HER2 ANTIBODY DRUG CONJUGATES
    Publication number: 20200377615
    Abstract: The present invention provides site specific HER2 antibody drug conjugates and methods for preparing and using the same.
    Type: Application
    Filed: June 3, 2020
    Publication date: December 3, 2020
    Applicant: Pfizer Inc.
    Inventors: Dangshe MA, Frank LOGANZO, Jr., Kimberly Ann MARQUETTE, Edmund Idris GRAZIANI, Puja SAPRA, Pavel STROP
  • RADIOLABELED ANTI-PD-L1 ANTIBODIES FOR IMMUNO-PET IMAGING
    Publication number: 20200345872
    Abstract: Radiolabeled anti-PD-L1 antibodies and their use in immuno-PET imaging are provided herein. Included are methods of detecting the presence of PD-L1 proteins in a patient or sample.
    Type: Application
    Filed: June 29, 2020
    Publication date: November 5, 2020
    Inventors: Marcus Kelly, Dangshe Ma, William Olson, Gavin Thurston
  • Radiolabeled anti-PD-L1 antibodies for immuno-PET imaging
    Patent number: 10736976
    Abstract: Radiolabeled anti-PD-L1 antibodies and their use in immuno-PET imaging are provided herein. Included are methods of detecting the presence of PD-L1 proteins in a patient or sample.
    Type: Grant
    Filed: December 1, 2017
    Date of Patent: August 11, 2020
    Assignee: REGENERON PHARMACEUTICALS, INC.
    Inventors: Marcus Kelly, Dangshe Ma, William Olson, Gavin Thurston
  • Anti-CD8 antibodies and uses thereof
    Patent number: 10730944
    Abstract: Anti-CD8 antibodies, radiolabeled anti-CD8 antibodies, fluorescently labeled anti-CD8 antibodies and their use in imaging are provided herein. Included are methods of detecting the presence of CD8 proteins in a subject or sample.
    Type: Grant
    Filed: July 23, 2018
    Date of Patent: August 4, 2020
    Assignee: REGENERON PHARMACEUTICALS, INC.
    Inventors: Jason T. Giurleo, Dangshe Ma, William Olson, Richard Tavare, Gavin Thurston
  • Site specific HER2 antibody drug conjugates
    Patent number: 10689458
    Abstract: The present invention provides site specific HER2 antibody drug conjugates and methods for preparing and using the same.
    Type: Grant
    Filed: November 21, 2016
    Date of Patent: June 23, 2020
    Assignee: Pfizer Inc.
    Inventors: Dangshe Ma, Frank Loganzo, Jr., Kimberly Ann Marquette, Edmund Idris Graziani, Puja Sapra, Pavel Strop
  • ANTIBODIES AND ANTIBODY FRAGMENTS FOR SITE-SPECIFIC CONJUGATION
    Publication number: 20200069764
    Abstract: The invention relates to polypeptides, antibodies, and antigen-binding fragments thereof, that comprise a substituted cysteine for site-specific conjugation.
    Type: Application
    Filed: November 19, 2019
    Publication date: March 5, 2020
    Applicant: Pfizer Inc.
    Inventors: Dangshe MA, Kimberly Ann MARQUETTE, Edmund Idris GRAZIANI, Puja SAPRA, Lawrence Nathan TUMEY, Nadira Anarkali PRASHAD, Kiran Manohar KHANDKE, Eric M. BENNETT, Lioudmila TCHISTIAKOVA
  • ANTI-CD8 ANTIBODIES AND USES THEREOF
    Publication number: 20190023790
    Abstract: Anti-CD8 antibodies, radiolabeled anti-CD8 antibodies, fluorescently labeled anti-CD8 antibodies and their use in imaging are provided herein. Included are methods of detecting the presence of CD8 proteins in a subject or sample.
    Type: Application
    Filed: July 23, 2018
    Publication date: January 24, 2019
    Inventors: Jason T. Giurleo, Dangshe Ma, William Olson, Richard Tavare, Gavin Thurston
  • RADIOLABELED ANTI-LAG3 ANTIBODIES FOR IMMUNO-PET IMAGING
    Publication number: 20180228926
    Abstract: Radiolabeled anti-LAG3 antibodies and their use in immuno-PET imaging are provided herein. Included are methods of detecting the presence of LAG3 proteins in a patient or sample.
    Type: Application
    Filed: February 9, 2018
    Publication date: August 16, 2018
    Inventors: Marcus Kelly, Dangshe Ma, William Olson, Gavin Thurston, Richard Tavare
  • RADIOLABELED ANTI-PD-L1 ANTIBODIES FOR IMMUNO-PET IMAGING
    Publication number: 20180161464
    Abstract: Radiolabeled anti-PD-L1 antibodies and their use in immuno-PET imaging are provided herein. Included are methods of detecting the presence of PD-L1 proteins in a patient or sample.
    Type: Application
    Filed: December 1, 2017
    Publication date: June 14, 2018
    Inventors: Marcus Kelly, Dangshe Ma, William Olson, Gavin Thurston