Patents by Inventor Danie Lagrange

Danie Lagrange has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nucleic acids encoding fungal cellobiohydrolases for expression in yeast
    Patent number: 11530428
    Abstract: The present invention provides for heterologous expression of polypeptides encoded by wild-type and condon-optimized variants of cbh1 and/or cbh2 from the fungal organisms Talaromyces emersonii (T. emersonii), Humicola grisea (H. grisea), Thermoascus aurantiacus (T. aurantiacus), and Trichoderma reesei (T. reesei) in host cells, such as the yeast Saccharomyces cerevisiae. The expression in such host cells of the corresponding genes, and variants and combinations thereof, result in improved specific activity of the expressed cellobiohydrolases. Thus, such genes and expression systems are useful for efficient and cost-effective consolidated bioprocessing systems.
    Type: Grant
    Filed: May 25, 2016
    Date of Patent: December 20, 2022
    Inventors: Riaan Den Haan, Emile Van Zyl, Danie LaGrange
  • HETEROLOGOUS EXPRESSION OF FUNGAL CELLOBIOHYDROLASES IN YEAST
    Publication number: 20160326560
    Abstract: The present invention provides for heterologous expression of polypeptides encoded by wild-type and condon-optimized variants of cbh1 and/or cbh2 from the fungal organisms Talaromyces emersonii (T. emersonii), Humicola grisea (H. grisea), Thermoascus aurantiacus (T. aurantiacus), and Trichoderma reesei (T. reesei) in host cells, such as the yeast Saccharomyces cerevisiae. The expression in such host cells of the corresponding genes, and variants and combinations thereof, result in improved specific activity of the expressed cellobiohydrolases. Thus, such genes and expression systems are useful for efficient and cost-effective consolidated bioprocessing systems.
    Type: Application
    Filed: May 25, 2016
    Publication date: November 10, 2016
    Inventors: Riaan Den Haan, Emile Van Zyl, Danie LaGrange
  • Nucleic acids encoding fungal cellobiohydrolases for expression in yeast
    Patent number: 9365842
    Abstract: The present invention provides for heterologous expression of polypeptides encoded by wild-type and codon-optimized variants of cbh1 and/or cbh2 from the fungal organisms Talaromyces emersonii (T. emersonii), Humicola grisea (H. grisea), Thermoascus aurantiacus (T. aurantiacus), and Trichoderma reesei (T. reesei) in host cells, such as the yeast Saccharomyces cerevisiae. The expression in such host cells of the corresponding genes, and variants and combinations thereof, result in improved specific activity of the expressed cellobiohydrolases. Thus, such genes and expression systems are useful for efficient and cost-effective consolidated bioprocessing systems.
    Type: Grant
    Filed: May 11, 2009
    Date of Patent: June 14, 2016
    Assignee: Stellenbosch University
    Inventors: Riaan Den Haan, Emile Van Zyl, Danie Lagrange
  • Yeast cells expressing an exogenous cellulosome and methods of using the same
    Patent number: 9315833
    Abstract: The present invention relates to the engineering and expression of heterologous cellulosomes in microorganisms in order to facilitate the conversion of biomass to useful products. In some embodiments, the invention relates to the expression of scaffoldin proteins which form the nucleus of a cellulosome. Cellulases or other biomass-degrading enzymes can be non-covalently linked to the scaffoldin protein by virtue of a dockerin domain-cohesin domain interaction.
    Type: Grant
    Filed: February 18, 2010
    Date of Patent: April 19, 2016
    Assignees: Lallemand Hungary Liquidity Management LLC, Stellenbosch University
    Inventors: John McBride, Mark Mellon, Vineet Rajgarhia, Elena E. Brevnova, Erin Wiswall, David A. Hogsett, Danie LaGrange, Shaunita Rose, Emile Van Zyl
  • Yeast Cells Expressing An Exogenous Cellulosome And Methods of Using The Same
    Publication number: 20120142046
    Abstract: The present invention relates to the engineering and expression of heterologous cellulosomes in microorganisms in order to facilitate the conversion of biomass to useful products. In some embodiments, the invention relates to the expression of scaffoldin proteins which form the nucleus of a cellulosome. Cellulases or other biomass-degrading enzymes can be non-covalently linked to the scaffoldin protein by virtue of a dockerin domain-cohesin domain interaction.
    Type: Application
    Filed: February 18, 2010
    Publication date: June 7, 2012
    Inventors: John McBride, Mark Mellon, Vineet Rajgarhia, Elena E. Brevnova, Erin Wiswall, David A. Hogsett, Danie LaGrange, Shaunita Rose, Emile Van Zyl
  • Heterologous Expression of Fungal Cellobiohydrolases in Yeast
    Publication number: 20110124074
    Abstract: The present invention provides for heterologous expression of polypeptides encoded by wild-type and codon-optimized variants of cbh1 and/or cbh2 from the fungal organisms Talaromyces emersonii (T. emersonii), Humicola grisea (H. grisea), Thermoascus aurantiacus (T. aurantiacus), and Trichoderma reesei (T. reesei) in host cells, such as the yeast Saccharomyces cerevisiae. The expression in such host cells of the corresponding genes, and variants and combinations thereof, result in improved specific activity of the expressed cellobiohydrolases. Thus, such genes and expression systems are useful for efficient and cost-effective consolidated bioprocessing systems.
    Type: Application
    Filed: May 11, 2009
    Publication date: May 26, 2011
    Applicant: Stellenbosch University
    Inventors: Riaan Den Haan, Emile Van Zyl, Danie Lagrange