Patents by Inventor Daniel A. Benigni

Daniel A. Benigni has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for the preparation, isolation and purification of epothilone B, and X-ray crystal structures of epothilone B
    Patent number: 7241899
    Abstract: The present invention relates to improved methods for the production, isolation and purification of epothilone B. These methods include, for example, a fermentation process for the production of epothilone B, isolation via adsorption onto a resin, and subsequent purification.
    Type: Grant
    Filed: March 22, 2004
    Date of Patent: July 10, 2007
    Assignee: Bristol-Myers Squibb Company
    Inventors: Daniel A. Benigni, Jack Z. Gougoutas, John D. DiMarco
  • Methods for the Preparation, Isolation and Purification of Epothilone B, and X-Ray Crystal Structures of Epothilone B
    Publication number: 20070122891
    Abstract: The present invention relates to improved methods for the production, isolation and purification of epothilone B. These methods include, for example, a fermentation process for the production of epothilone B, isolation via adsorption onto a resin, and subsequent purification.
    Type: Application
    Filed: January 31, 2007
    Publication date: May 31, 2007
    Inventors: Daniel Benigni, Robert Stankavage, Shu-Jen Chiang, Hsing Hou, Bruce Eagan, Dennis Gu, David Hou, Les Mintzmyer, Thomas Tully, Brian Davis, Ivan Hargro, Mark Mascari, Gabriel Galvin, Gregory Stein, Cary McConlogue, Fahri Comezoglu
  • Methods for the preparation, isolation and purification of epothilone B, and x-ray crystal structures of epothilone B
    Patent number: 7172884
    Abstract: The present invention relates to improved methods for the production, isolation and purification of epothilone B. These methods include, for example, a fermentation process for the production of epothilone B, isolation via adsorption onto a resin, and subsequent purification.
    Type: Grant
    Filed: September 22, 2003
    Date of Patent: February 6, 2007
    Assignee: Bristol-Myers Squibb Company
    Inventors: Daniel Benigni, Robert Stankavage, Shu-Jen Chiang, Hsing Hou, Bruce Eagan, Dennis Gu, David Hou, Les Mintzmyer, Thomas P. Tully, Brian L. Davis, Ivan Hargro, Mark Mascari, Gabriel Galvin, Gregory Stein, Cary W. McConlogue, Fahri T. Comezoglu
  • Methods for the preparation, isolation and purification of epothilone B, and X-ray crystal structures of epothilone B
    Publication number: 20060135474
    Abstract: The present invention relates to improved methods for the production, isolation and purification of epothilone B. These methods include, for example, a fermentation process for the production of epothilone B, isolation via adsorption onto a resin, and subsequent purification.
    Type: Application
    Filed: March 22, 2004
    Publication date: June 22, 2006
    Inventors: Daniel Benigni, Jack Gougoutas, John DiMarco
  • Paclitaxel solvates
    Patent number: 6858644
    Abstract: Biologically active crystalline solvates of paclitaxel are precipitated using polar, aprotic, organic solvents. A pharmaceutical composition is also disclosed, as well as the preparation of the novel solvates and their uses as anti-tumor agents.
    Type: Grant
    Filed: November 26, 2002
    Date of Patent: February 22, 2005
    Assignee: Bristol-Myers Squibb Co.
    Inventors: Daniel A. Benigni, Jack Z. Gougoutas, John D. DiMarco
  • Methods for the preparation, isolation and purification of epothilone B, and x-ray crystal structures of epothilone B
    Publication number: 20040132146
    Abstract: The present invention relates to improved methods for the production, isolation and purification of epothilone B. These methods include, for example, a fermentation process for the production of epothilone B, isolation via adsorption onto a resin, and subsequent purification.
    Type: Application
    Filed: September 22, 2003
    Publication date: July 8, 2004
    Inventors: Daniel Benigni, Robert Stankavage, Shu-Jen Chiang, Hsing Hou, Bruce Eagan, Dennis Gu, David Hou, Les Mintzmyer, Thomas P. Tully, Brian L. Davis, Ivan Hargro, Mark Mascari, Gabriel Galvin, Gregory Stein, Cary W. McConlogue, Fahri T. Comezoglu
  • Paclitaxel solvates
    Publication number: 20030144344
    Abstract: Biologically active crystalline solvates of paclitaxel are precipitated using polar, aprotic, organic solvents. A pharmaceutical composition is also disclosed, as well as the preparation of the novel solvates and their uses as anti-tumor agents.
    Type: Application
    Filed: November 26, 2002
    Publication date: July 31, 2003
    Inventors: Daniel A. Benigni, Jack Z. Gougoutas, John D. DiMarco
  • Process for preparing dithio-ethylanino 9A-methoxymitosanes
    Patent number: 5352798
    Abstract: 7-(Diphenylmethyl)oxy-9a-methoxymitosane is a novel intermediate for conversion into 7-amino and 7-oxy-9a-methoxymitosanes and is also useful for inhibiting mammalian tumor growth. The compound is prepared by reacting 7-hydroxy-9a-methoxymitosane with diazodiphenylmethane. In a preferred reaction, the compound is prepared from mitomycin C via 7-hydroxy-9a-methoxymitosane without drying (water removal). The intermediate is advantageously converted to the very effective anti-tumor agent 7-[2-(4-nitrophenyldithio)ethylamino]-9a-methoxymitosane in unexpectedly high yields using a two step process where the first step constitutes conversion to 7-[2-(2-pyridyldithio)ethylamino]-9a-methoxymitosane or 7-[2-(3-nitro-2-pyridyldithio)ethylamino]-9a-methoxymitosane.
    Type: Grant
    Filed: September 16, 1992
    Date of Patent: October 4, 1994
    Assignee: Bristol-Myers Squibb Company
    Inventors: Daniel A. Benigni, Kenton L. Shultis
  • Preparation of 7-(diphenylmethyl)oxy-9A-methoxymitosane
    Patent number: 5175303
    Abstract: 7-(Diphenylmethyl)oxy-9a-methoxymitosane is a novel intermediate for conversion into 7-amino and 7-oxy-9a-methoxymitosanes and is also useful for inhibiting mammalian tumor growth. The compound is prepared by reacting 7-hydroxy-9a-methoxymitosane with diazodiphenylmethane. In a preferred reaction, the compound is prepared from mitomycin C via 7-hydroxy-9a-methoxymitosane without drying (water removal). The intermediate is advantageously converted to the very effective anti-tumor agent 7-[2-(4-nitrophenyldithio) ethylamino]-9a-methoxymitosane in unexpectedly high yields using a two step process where the first step constitutes conversion to 7-[2-(2-pyridyldithio) ethylamino]-9a-methoxymitosane. or 7-[2-(3-nitro-2-pyridyldithio)ethylamino]-9a-methoxymitosane.
    Type: Grant
    Filed: September 27, 1991
    Date of Patent: December 29, 1992
    Assignee: Bristol-Myers Squibb Company
    Inventors: Daniel A. Benigni, Kenton L. Shultis, Henry S. L. Wong
  • 7-(diphenylmethyl)oxy-9a-methoxymitosane
    Patent number: 5075454
    Abstract: 7-(Diphenylmethyl)oxy-9a-methoxymitosane is a novel intermediate for conversion into 7-amino and 7-oxy-9a-methoxymitosanes and is also useful for inhibiting mammalian tumor growth. The compound is prepared by reacting 7-hydroxy-9a-methoxymitosane with diazodiphenylmethane. In a preferred reaction, the compound is prepared from mitomycin C via 7-hydroxy-9a-methoxymitosane without drying (water removal). The intermediate is advantageously converted to the very effective anti-tumor agent 7-[2-(4-nitrophenyldithio)ethylamino]-9a-methoxymitosane in unexpectedly high yields using a two step process where the first step constitutes conversion to 7-[2-(2-pyridyldithio)ethylamino]-9a-methoxymitosane or 7-[2-(3-nitro-2-pyridyldithio)ethylamino]-9a-methoxymitosane.
    Type: Grant
    Filed: March 8, 1990
    Date of Patent: December 24, 1991
    Assignee: Bristol-Myers Squibb Company
    Inventors: Daniel A. Benigni, Kenton L. Shultis, Henry S. L. Wong
  • Dideoxyinosine by enzymatic deamination of dideoxyadenosine
    Patent number: 5011774
    Abstract: A novel process utilizing adenosine deaminase to selectively produce .beta.-(D)-2',3'-dideoxyinosine in high yields from an .alpha.,.beta.-anomeric mixture. .beta.-(D)-2',3'-Dideoxyinosine so produced is useful as an antiviral and antibiotic agent.
    Type: Grant
    Filed: February 28, 1990
    Date of Patent: April 30, 1991
    Assignee: Bristol-Myers Squibb Co.
    Inventors: Vittorio Farina, Daniel A. Benigni, Paul R. Brodfuehrer
  • Methods for the preparation, isolation and purification of epothilone B, and X-ray crystal structures of epothilone B
    Patent number: RE42191
    Abstract: The present invention relates to improved methods for the production, isolation and purification of epothilone B. These methods include, for example, a fermentation process for the production of epothilone B, isolation via adsorption onto a resin, and subsequent purification.
    Type: Grant
    Filed: August 6, 2009
    Date of Patent: March 1, 2011
    Assignee: Bristol-Myers Squibb Company
    Inventors: Daniel Benigni, Thomas P. Tully, Brian L. Davis