Abstract: There is provided a data transmission and compression method arranged to compress and transmit data between an edge device and a remote server. The method comprises collecting data at the edge device, wherein the data is attributed to a plurality of signal signatures; generating a data matrix at the edge device; transforming the data matrix, wherein transforming the data comprises using a wavelet transform; compressing the data, wherein compressing the data comprises utilising an autoencoder; and transmitting the encoded compressed data to the remote server via a communication channel. The method further comprises, at the remote server, decompressing the data utilising an autoencoder; reconstructing the signal signatures using an inverse wavelet transform; and storing the reconstructed data signatures in a datastore on the remote server.

Abstract: Provided herein are pharmaceutical compositions for local administration of metabolic inhibitors, methods of locally administering such compositions, and rapid diagnostic methods for identifying mutant allele during the course of a surgical procedure.

Abstract: A braking system may include a controller, a first wheel and a second wheel. The first wheel may be laterally displaced from the second wheel by a first distance. A first wheel speed sensor may be coupled to the first wheel and a second wheel sensor may be coupled to the second wheel. The controller may be configured to determine at least one of a slip ratio, a coefficient of friction, or a braking pressure of the second wheel in response to failure of the first wheel speed sensor. The controller may be configured to calculate a consistency value of the at least one of the slip ratio, the coefficient of friction, or the braking pressure. The controller may be configured to adjust a braking pressure of the first wheel speed sensor based upon the consistency value and the first distance.

Abstract: A brake control system (BCS) may comprise a first controller, a second controller in electronic communication with the first controller, and a valve comprising a first coil and a second coil. The first controller may be configured to actuate the valve via the first coil. The second controller may be configured to actuate the valve via the second coil. The first controller may be configured to disable the second controller to take over control of the valve.

Abstract: A braking system may include a controller, a first wheel and a second wheel. The first wheel may be laterally displaced from the second wheel by a first distance. A first wheel speed sensor may be coupled to the first wheel and a second wheel sensor may be coupled to the second wheel. The controller may be configured to determine at least one of a slip ratio, a coefficient of friction, or a braking pressure of the second wheel in response to failure of the first wheel speed sensor. The controller may be configured to calculate a consistency value of the at least one of the slip ratio, the coefficient of friction, or the braking pressure. The controller may be configured to adjust a braking pressure of the first wheel speed sensor based upon the consistency value and the first distance.

Abstract: An emergency park brake system of an aircraft may include a user input interface configured to receive actuation input from a user. The emergency park brake system may also include a first displacement sensor and a second displacement sensor that are both coupled to the user input interface. The first displacement sensor may be configured to detect displacement of the user input interface and generate a first status of the user input interface and the second displacement sensor may be configured to also detect displacement of the user input interface and generate a second status of the user input interface. The emergency park brake system may also include a controller having a processor and memory. The controller may be configured to determine an emergency park brake condition.

Abstract: A braking system may include a controller, a first wheel and a second wheel. The first wheel may be laterally displaced from the second wheel by a first distance. A first wheel speed sensor may be coupled to the first wheel and a second wheel sensor may be coupled to the second wheel. The controller may be configured to determine at least one of a slip ratio, a coefficient of friction, or a braking pressure of the second wheel in response to failure of the first wheel speed sensor. The controller may be configured to calculate a consistency value of the at least one of the slip ratio, the coefficient of friction, or the braking pressure. The controller may be configured to adjust a braking pressure of the first wheel speed sensor based upon the consistency value and the first distance.

Abstract: A displacement sensor includes a resistive element and a wiper element. The wiper element is separated from the resistive element in a parked mode the wiper element is in sliding electrical contact with the resistive element in a sensing mode. A user input interface may be coupled to at least one of the resistive element and the wiper element, wherein whether the displacement sensor is in the parked mode or the sensing mode is dependent on actuation of the user input interface.

Abstract: Provided herein are pharmaceutical compositions for local administration of metabolic inhibitors, methods of locally administering such compositions, and rapid diagnostic methods for identifying mutant allele during the course of a surgical procedure.

Abstract: Systems and methods for an aircraft emergency and park brake system are disclosed. The emergency and park brake system may comprise an emergency and park brake controller. The emergency and park brake controller may be configured to receive brake signals from mechanical and electrical inputs, generate a braking command comprising data from the brake signal, and transmit the braking command to control braking force. The emergency and park brake controller may receive brake signals from multiple locations including from the aircraft and from a remote location.

Abstract: An electrically controlled park and emergency brake system is disclosed. The brake system may comprise a brake control module having a shut-off valve in fluid communication with an outboard servo-valve and an inboard servo-valve. An emergency/park power source may supply fluid to the shut-off valve. The brake system may also comprise a vehicle management system in electronic communication with the brake control module. The brake system may also comprise mechanical inputs, including a wheel well brake handle and a cockpit brake handle. The brake system may also comprise redundant emergency/park power sources.

Abstract: A brake control system (BCS) may comprise a first controller, a second controller in electronic communication with the first controller, and a valve comprising a first coil and a second coil. The first controller may be configured to actuate the valve via the first coil. The second controller may be configured to actuate the valve via the second coil. The first controller may be configured to disable the second controller to take over control of the valve.

Abstract: A brake system may comprise a controller, a vehicle management system (VMS) in communication with the controller, a valve in communication with the controller, and a tangible, non-transitory memory configured to communicate with the controller, the tangible, non-transitory memory having instructions stored thereon that, in response to execution by the controller, cause the controller to perform operations comprising determining, by the controller, that a first enable signal is received by the controller from the VMS, determining, by the controller, that a second enable signal is received by the controller from the VMS, and disabling, by the controller, the controller from control of the valve in response to the first enable signal and the second enable signal.

Abstract: A controller unit for an aircraft control system includes an interface that is electrically connectable to a controller slot of an electronics bay of the aircraft control system, a processor coupled to the interface, and a tangible non-transitory computer-readable medium having instructions stored thereon that, in response to execution by the processor, cause the processor to perform various operations. The various operations include identifying, by the processor, a first aircraft assembly in electrical communication with the controller slot of the electronics bay, identifying, by the processor, a first program code stored on the tangible non-transitory computer-readable medium corresponding to the first aircraft assembly, and selecting, by the processor, the first program code to control the first aircraft assembly.

Abstract: A brake system of an aircraft may include a first brake control assembly, a second brake control assembly, a first brake control unit electrically coupled to the first brake control assembly, a second brake control unit electrically coupled to the second brake control assembly, and an arbitration control module. The arbitration control module may be configured to determine an operational integrity of the first brake control unit and the second brake control unit. In response to determining that one of the first brake control unit and the second brake control unit does not have sufficient operational integrity, the arbitration control module may enable the other of the first brake control unit and the second brake control unit to control both the first brake control assembly and the second brake control assembly.

Abstract: A hydraulic brake valve system may comprise a valve housing comprising a brake port, a pressure port, a return port, and a valve actuation end; a valve shaft coupled to the valve actuation end, wherein the valve shaft may be comprised at least partially within the valve housing; and an electric actuator coupled to the valve shaft, wherein the electric actuator may be configured to move the valve shaft between a shaft on position and a shaft off position. The hydraulic brake valve system may be configured to pass hydraulic pressure through at least one of the brake port, the pressure port, or the return port in response to a position of the valve shaft.

Abstract: A brake system may comprise a controller, a vehicle management system (VMS) in communication with the controller, a valve in communication with the controller, and a tangible, non-transitory memory configured to communicate with the controller, the tangible, non-transitory memory having instructions stored thereon that, in response to execution by the controller, cause the controller to perform operations comprising determining, by the controller, that a first enable signal is received by the controller from the VMS, determining, by the controller, that a second enable signal is received by the controller from the VMS, and disabling, by the controller, the controller from control of the valve in response to the first enable signal and the second enable signal.

Abstract: An emergency park brake system of an aircraft may include a user input interface configured to receive actuation input from a user. The emergency park brake system may also include a first displacement sensor and a second displacement sensor that are both coupled to the user input interface. The first displacement sensor may be configured to detect displacement of the user input interface and generate a first status of the user input interface and the second displacement sensor may be configured to also detect displacement of the user input interface and generate a second status of the user input interface. The emergency park brake system may also include a controller having a processor and memory. The controller may be configured to determine an emergency park brake condition.

Abstract: A valve includes an electrical park valve configured to receive an electrical park signal and to allow hydraulic fluid to flow through a first electrically-controlled channel in response to the signal indicating a parking request, and a main valve configured to receive the hydraulic fluid from the first electrically-controlled channel and to allow the hydraulic fluid to flow to a braking actuator in response to receiving the hydraulic fluid. The valve also includes an electrical emergency control valve configured to allow the hydraulic fluid to flow through a first control channel in response to a request for emergency braking. The valve also includes an emergency enable valve configured to receive the hydraulic fluid from the first control channel and to allow the hydraulic fluid to flow to the braking actuator in response to receiving the hydraulic fluid from the electrical emergency control valve.

Abstract: A hydraulic park brake system for an aircraft may include a hydraulic park brake controller having a processor and a tangible, non-transitory memory configured to communicate with the processor. The tangible, non-transitory memory may have instructions stored thereon that, in response to execution by the processor, cause the hydraulic park brake system to perform various operations. Such operations may include receiving, by the processor, a hydraulic park brake condition, comparing, by the processor, the hydraulic park brake condition with a predetermined condition to yield comparison data, and determining, by the processor and based on the comparison data, a hydraulic park brake adjustment status. Such operations may further include generating, by the processor and based on the hydraulic park brake adjustment status, an adjustment command and transmitting, by the processor, the adjustment command to a hydraulic park brake of the aircraft.