Abstract: The present invention relates to interferometric detection of particles and optical detection of particles having size dimensions less than or equal to 100 nm. Systems and methods are provided exhibiting enhanced alignment and stability for interferometric detection of particles and/or optical detection of particles having size dimensions less than or equal to 100 nm. Systems and methods are provided that include compensation means for mitigating the impact of internal and external stimuli and changes in operating conditions that can degrade the sensitivity and reliability of particle detection via optical methods, including interferometric-based techniques and/or systems for optical detection of particles having size dimensions less than or equal to 100 nm.

Abstract: This invention relates to compounds of Formula (I): and enantiomers thereof, and to pharmaceutically acceptable salts of Formula (I) and said enantiomers, wherein L1, L2, R1, R2, R3 and n are as defined herein. The invention further relates to pharmaceutical compositions comprising such compounds and salts, and to methods and uses of such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer, in a subject in need thereof.

Abstract: An example operation includes one or more of: determining a first subgroup of a group of vehicles and a second subgroup of the group of vehicles, wherein the second subgroup has a higher carbon footprint than the first subgroup; and determining a driving behavior modification of a vehicle in the second subgroup based on a driving behavior of one or more vehicles in the first subgroup.

Abstract: An example operation includes one or more of determining a first carbon footprint of a first mode of transportation and a second carbon footprint of a second mode of transportation, where the first mode of transportation is a primary mode of transportation and the second carbon footprint is less than the first carbon footprint, responsive to the first carbon footprint being above a threshold, calculating a period of time the second mode of transportation is utilized to negate an amount above the threshold, and sending a notification to use the second mode of transportation for the period of time.

Abstract: This invention relates to compounds of Formula (I): and enantiomers thereof, and to pharmaceutically acceptable salts of Formula (I) and said enantiomers, wherein L1, L2, R1, R2, R3 and n are as defined herein. The invention further relates to pharmaceutical compositions comprising such compounds and salts, and to methods and uses of such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer, in a subject in need thereof.

Abstract: Nanostructures and nanostructure-based vaccines that display antigens capable of eliciting immune responses to infectious agents such as bacteria, viruses, and pathogens are provided. Some vaccines are useful for preventing or decreasing the severity of infection with an infectious agent, including, for example and without limitation, lyme disease, pertussis, herpes virus, orthomyxovirus, paramyxovirus, pneumovirus, filovirus, flavivirus, reovirus, retrovirus, meningococcus, or malaria. The antigens may be attached to the core of the nanostructure either non-covalently or covalently, including as a fusion protein or by other means. Multimeric antigens may optionally be displayed along a symmetry axis of the nanostructure. Also provided are proteins and nucleic acid molecules encoding such proteins, vaccine compositions, and methods of administration.

Abstract: Synthetic nanostructures, polypeptides that are useful, for example, in making synthetic nanostructures, and methods for using such synthetic nanostructures are disclosed herein.

Abstract: The disclosure provides non-naturally occurring mutant neuraminidase (NA) polypeptides that improve expression and or modifies the open/closed tetrameric conformational state of the NA polypeptide, and uses thereof.

Abstract: This invention relates to compounds of Formula (I): and enantiomers thereof, and to pharmaceutically acceptable salts of Formula (I) and said enantiomers, wherein A, L2, R1, R2, R3, R4, and n are as defined herein. The invention further relates to pharmaceutical compositions comprising such compounds and salts, and to methods and uses of such compounds, salts, and compositions for the treatment of abnormal cell growth, including cancer, in a subject in need thereof.

Abstract: This invention relates to compounds of Formula (I): and enantiomers thereof, and to pharmaceutically acceptable salts of Formula (I) and said enantiomers, wherein L1, L2, R1, R2, R3 and n are as defined herein. The invention further relates to pharmaceutical compositions comprising such compounds and salts, and to methods and uses of such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer, in a subject in need thereof.

Abstract: A robotic system for treating a patient includes a robotic arm with an end effector for treating the patient, wherein the robotic arm is configured to be movable in a space surrounding the patient, and the end effector is configured to be movable individually and co-movable with the robotic arm in said space; a sensing device for acquiring data associating with coordinates and images of the end effector and the patient; and a controller in communications with the robotic arm and the sensing device for controlling movements of the robotic arm with the end effector and treatments of the patient with the end effector based on the acquired data and a treatment plan.

Abstract: Systems and methods of controlling a docking station comprise establishing, by the wireless access point, a USB connection tunnelled over a local area wireless network connection with the mobile device, receiving, by the wireless access point over the USB connection, a request for an Internet Protocol (IP) or a Media Access Control (MAC) network address of the display controller, transmitting, by the wireless access point in response to the request, the IP or the MAC network address of the display controller to the mobile device over the USB connection, and receiving, by the wireless access point, the at least video data addressed to the IP or the MAC network address of the display controller and switching the at least video data addressed to the IP or the MAC network address of the display controller directly to the display controller without passing via the USB controller.

Abstract: Synthetic nanostructures, polypeptides that are useful, for example, in making synthetic nanostructures, and methods for using such synthetic nanostructures are disclosed herein.

Abstract: A computing system can include an embedding model and a clustering model. The computing system input each of the plurality of inputs into the embedding model and receiving respective embeddings for the plurality of inputs as outputs of the embedding model. The computing system can input the respective embeddings for the plurality of inputs into the clustering model and receiving respective cluster assignments for the plurality of inputs as outputs of the clustering model. The computing system can evaluate a clustering loss function that evaluates a first average, across the plurality of inputs, of a respective first entropy of each respective probability distribution; and a second entropy of a second average of the probability distributions for the plurality of inputs. The computing system can modify parameter(s) of one or both of the clustering model and the embedding model based on the clustering loss function.

Abstract: Provided herein are compositions and methods comprising mutated coronavirus “S” spike proteins or receptor binding domains thereof that have an increased expression level, yield and stability compared to its corresponding native or wild-type coronavirus spike protein under the same expression, culture or storage conditions. These mutated spike proteins can be used for generating a protein-based vaccine against one or more coronaviruses.

Abstract: Methods are provided for generating training triplets that can be used to train multidimensional embeddings to represent the semantic content of non-speech sounds present in a corpus of audio recordings. These training triplets can be used with a triplet loss function to train the multidimensional embeddings such that the embeddings can be used to cluster the contents of a corpus of audio recordings, to facilitate a query-by-example lookup from the corpus, to allow a small number of manually-labeled audio recordings to be generalized, or to facilitate some other audio classification task. The triplet sampling methods may be used individually or collectively, and each represent a respective heuristic about the semantic structure of audio recordings.

Abstract: Nanoparticles and vaccines containing these nano particles that elicit an immune response against hemagglutinin (HA) proteins from a broad range of influenza viruses are provided. The nanoparticles are made from self-assembling proteins, at least one of which is joined to an immunogenic portion of an influenza HA protein. This immunogenic portion is displayed on the nanoparticle surface, making the nanoparticles useful for vaccinating subjects against influenza virus.

Abstract: Synthetic nanostructures, polypeptides that are useful, for example, in making synthetic nanostructures, and methods for using synthetic nanostructures are disclosed herein.

Abstract: A method of configuring a Universal Serial Bus (USB) connection between a first and second devices, the USB connection comprising a plurality of data channels, each having a pair of signal links, each signal link including a port at either end of the connection, and a signal wire formed of one or more physical wires extending between corresponding ports. Each of the signal links are configured with a first direction for transmission of data. The first direction is determined based on an initial required data transmission capacity in each direction between the first and second devices. Thereafter, depending on required capacity in the different directions, a selection is made which of the signal links should change their direction of transmission from the first direction to a second direction and a redirection signal is sent to each of the selected signal links to cause the change in direction of transmission.

Abstract: The present disclosure provides systems and methods that generating health diagnostic information from an audio recording. A computing system can include a machine-learned health model comprising that includes a sound model trained to receive data descriptive of a patient audio recording and output sound description data. The computing system can include a diagnostic model trained to receive the sound description data and output a diagnostic score. The computing system can include at least one tangible, non-transitory computer-readable medium that stores instructions that, when executed, cause the processor to perform operations. The operations can include obtaining the patient audio recording; inputting data descriptive of the patient audio recording into the sound model; receiving, as an output of the sound model, the sound description data; inputting the sound description data into the diagnostic model; and receiving, as an output of the diagnostic model, the diagnostic score.