Abstract: The invention relates to a method for the production of L-carnitine, wherein a chiral ?-lactone carnitine precursor is obtained by a [2+2] cycloaddition of ketene with an aldehyde X—CH2—CHO, wherein X is selected from Cl, Br, I and trimethylamine, in the presence of a chiral catalyst.

Abstract: An electrosurgical generator may reduce unintended tissue damage by improving regulation of output power. The electrosurgical generator may control the power during a cycle, and react to a change in power if arcing occurs. Voltage sources, especially, demonstrate the tendency to have large, uncontrolled power excursions during normal electrosurgical use. The magnitude of the power excursions may be dependent on various factors. An exemplary electrosurgical generator control scheme reduces or minimizes the thermal spread by accurately supplying the specified power within a few cycles. Additionally, fast and accurate regulation provided by the constant voltage mode reduces or minimizes unintentional tissue charring. Thus, reduced thermal spread and charring should result in better surgical outcomes by reducing scarring and decreasing healing times.

Abstract: The invention relates to a method for the production of L-carnitine, wherein a chiral ?-lactone carnitine precursor is obtained by a [2+2] cycloaddition of ketene with an aldehyde X—CH2—CHO, wherein X is selected from Cl, Br, I and trimethylamine, in the presence of a chiral catalyst.

Abstract: The present invention relates in general to an inhibitor of a glutaminyl peptide cyclotransferase-like protein (QPCTL), and the use thereof for the treatment and/or prevention of an inflammatory disease or disorder selected from the group consisting of (a) chronic and acute inflammations, e.g. rheumatoid arthritis, atherosclerosis, restenosis, pancreatitis; (b) other inflammatory diseases, e.g. neuropathic pain, graft rejection/graft failure/graft vasculopathy, HIV infections/AIDS, gestosis, tuberous sclerosis, Guillain-Barré syndrome, chronic inflammatory demyelinising polyradiculoneuropathy and multiple sclerosis; (c) neuroinflammation; and (d) neurodegenerative diseases, e.g. mild cognitive impairment (MCI), Alzheimer's disease, neurodegeneration in Down Syndrome, Familial British Dementia, and Familial Danish Dementia, which may result from neuroinflammation.

Abstract: Serious asset management depends on financial portfolios being valued accurately in a timely and complete manner. Custom, and in some jurisdiction, rules and regulations demand that they be “marked to market”, i.e. that their valuation as closely as possible reflect the market value of the financial instruments that make up a portfolio. A structured database of financial instruments and system and method for updating the prices of these instruments (the DPSM or Deductive Pricing System and Method) permits the use of information contained in the structure of financial instruments to complement the available market information and to deduce prices for virtually all instruments in a portfolio, even if they are only rarely traded and market prices are not available at most times.

Abstract: The present invention discloses a method for therapeutically treating an animal, including a human, for psychosomatic, depressive and neuropsychiatric diseases, such as anxiety, depression, insomnia, schizophrenia, epilepsy, spasm and chronic pain. Administration of a suitable attractin inhibitor causes the reduction of activity in the enzyme attraction or in isoforms thereof in the brain of mammals and leads as a causal consequence to a reduced degradation of the neuropeptide Y (NPY) and similar substrates. Such treatment will result in a reduction or delay in the decrease of the concentration of functionally active neuronal NPY (1-36). As a consequence of the resulting enhanced stability of the endogenous NPY (1-36), NPY activity is prolonged thereby resulting among other things in functionally active NPY Y1 receptor activity thereby facilitating antidepressive, anxiolytic, analgesic, t antihypertension and other neurological effects.

Abstract: Downstream of the last roller pair of a drafting frame for a spinning machine, the roving is condensed in a fiber-bundling zone having a belt with perforations to which suction is applied. Another belt converges toward the belt with the perforations and engages the roving at a nip spaced from the nip formed by the last roller pair of the drafting frame so that the wedge-shaped converging of the two belts promotes the compacting or condensing action.

Abstract: Downstream of the last roller pair of a drafting frame for a spinning machine, the roving is condensed in a fiber-bundling zone having a belt with perforations to which suction is applied. Another belt converges toward the belt with the perforations and engages the roving at a nip spaced from the nip formed by the last roller pair of the drafting frame so that the wedge-shaped converging of the two belts promotes the compacting or condensing action.

Abstract: A reserve-surface cleaning apparatus is used in combination with a ring-spinning machine having a longitudinally extending row of spindles each adapted to hold a roving sleeve and each formed below the respective sleeve with a respective reserve winding area and a longitudinally extending frame extending along a back side of the row and a service area extending along a front side of the row. The cleaning system has a guide rail extending on the frame longitudinally along the back side of the row of spindles, a cleaner carriage displaceable longitudinally along the rail past the spindles, and a drive for displacing the cleaner carriage longitudinally along the rail past the spindles. A set of tools on the cleaner carriage strips roving from the reserve surfaces as the cleaner carriage passes same.

Abstract: In a ring-spinning or -twisting machine a longitudinal row of upright and normally rotating spindles mounted on a common support beam each have a lower reserve surface below a sleeve normally carried on the spindle. An apparatus for clearing roving wound on the surface has a guide rail extending longitudinally along a back side of the beam adjacent the spindles, a carriage displaceable along the rail past the spindles, and a drive including a longitudinally extending drive element secured to the carriage for displacing same longitudinally along the rail past the spindles. A roving-cutting element is fixed on the carriage engageable immediately adjacent the spindles between the respective lower reserve surfaces and sleeves and a roving-clearing element is fixed on the carriage below the cutting element and engageable immediately adjacent the lower reserve surfaces of the spindles.