Patents by Inventor Daniel A. Gamache

Daniel A. Gamache has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Treatment of dry eye by restoring 15-lipoxygenase activity to ocular surface cells
    Publication number: 20040248794
    Abstract: The present invention provides compositions comprising the 15-lipoxygenase-1 (15-LO-1) or 15-lipoxyngenase-2 (15-LO-2) gene such that 15-LO-1 or 15-LO-2 protein expression is replaced or replenished in the ocular surface epithelium of postmenopausal women suffering from dry eye. Thus, methods for treatment of dry eye in postmenopausal women are further provided.
    Type: Application
    Filed: October 17, 2003
    Publication date: December 9, 2004
    Inventors: John M. Yanni, Daniel A. Gamache, Steven T. Miller
  • Use of an h1 antagonist and a safe steroid to treat rhinitis
    Publication number: 20040242638
    Abstract: Compositions and methods for treating rhinitis with H1 antagonists/antiallergics and safe steroids are disclosed.
    Type: Application
    Filed: June 2, 2004
    Publication date: December 2, 2004
    Inventors: John M Yanni, Daniel A Gamache
  • Use of hydroxyeicosatetraenoic acid compounds to treat ophthalmic inflammatory disorders
    Patent number: 6825232
    Abstract: The topical use of HETE compounds to treat ophthalmic inflammatory disorders involving cytokines is disclosed.
    Type: Grant
    Filed: April 9, 2003
    Date of Patent: November 30, 2004
    Assignee: Alcon, Inc.
    Inventor: Daniel A. Gamache
  • Use of oculosurface selective glucocorticoid in the treatment of dry eye
    Publication number: 20040132704
    Abstract: Topical ophthalmic compositions and methods for treating dry eye are described. The compositions and methods of the invention are based on the finding that the oculosurface selective properties of the glucocorticoid rimexolone make this anti-inflammatory agent particularly well-suited for treating dry eye. As a result of the limited ability of rimexolone to penetrate the cornea, a high portion of the drug remains on the surface of the eye, which is the primary locus of the inflammatory conditions associated with dry eye. This enables a very low concentration of drug to be utilized, which in turn reduces the potential for elevations of intraocular pressure and cataract formation.
    Type: Application
    Filed: December 18, 2003
    Publication date: July 8, 2004
    Inventors: John M. Yanni, Daniel A. Gamache, Steven T. Miller, Ernesto J. Castillo
  • Method of treating neurodgenerative disorders of the retina and optic nerve head
    Publication number: 20040132773
    Abstract: The use of 3-benzolphenylacetic acids and derivatives, including nepafenac, to treat neurodegenerative retinal disorders is disclosed.
    Type: Application
    Filed: February 14, 2003
    Publication date: July 8, 2004
    Inventors: Daniel A Gamache, Gustav Graff, John M Yanni, Michael A Kapin
  • Methods of treating dry eye disorders
    Publication number: 20040058875
    Abstract: Inhibitors of cytokine synthesis in nonimmune, resident ocular surface cells are useful for treating dry eye disorders and other disorders requiring the wetting of the eye.
    Type: Application
    Filed: August 26, 2003
    Publication date: March 25, 2004
    Applicant: Alcon, Inc.
    Inventor: Daniel A. Gamache
  • PDE IV inhibitors to treat angiogenesis
    Publication number: 20040053939
    Abstract: Selective PDE-IV inhibitors are useful for preventing and treating angiogenic/edema related diseases and disorders.
    Type: Application
    Filed: September 11, 2003
    Publication date: March 18, 2004
    Inventors: Daniel A. Gamache, David P. Bingaman, Michael A. Kapin
  • Use of NF-&kgr;B inhibitors to treat dry eye disorders
    Patent number: 6696453
    Abstract: NF-&kgr;B inhibitors are useful for treating dry eye disorders and other disorders requiring the wetting of the eye.
    Type: Grant
    Filed: May 17, 2002
    Date of Patent: February 24, 2004
    Assignee: Alcon, Inc.
    Inventors: Daniel A. Gamache, John M. Yanni
  • Topical use of hydroxyeicosatetraenoic acid compounds to treat psoriasis
    Publication number: 20040002514
    Abstract: The topical use of HETE compounds to treat psoriasis is disclosed.
    Type: Application
    Filed: April 9, 2003
    Publication date: January 1, 2004
    Applicant: Alcon, Inc.
    Inventor: Daniel A. Gamache
  • Use of hydroxyeicosatetraenoic acid compounds to treat vaginal dryness
    Publication number: 20030236284
    Abstract: The use of HETE compounds to treat vaginal dryness is disclosed.
    Type: Application
    Filed: April 9, 2003
    Publication date: December 25, 2003
    Applicant: Alcon, Inc.
    Inventors: John M. Yanni, Daniel A. Gamache, Michael Van Wie Bergamini
  • Use of hydroxyeicosatetraenoic acid compounds to treat ophthalmic inflammatory disorders
    Publication number: 20030236307
    Abstract: The topical use of HETE compounds to treat ophthalmic inflammatory disorders involving cytokines is disclosed.
    Type: Application
    Filed: April 9, 2003
    Publication date: December 25, 2003
    Applicant: Alcon, Inc.
    Inventor: Daniel A. Gamache
  • Use of hydroxyeicosatetraenoic acid compounds to treat dry mouth
    Publication number: 20030232858
    Abstract: The use of HETE compounds to treat dry mouth is disclosed. According to the methods of the present invention, a HETE compound is administered to the oral cavity of a patient.
    Type: Application
    Filed: April 9, 2003
    Publication date: December 18, 2003
    Inventors: Ronnie C. Barker, Daniel A. Gamache
  • Lipoxin A4 and its analogs for the treatment of dry eye
    Patent number: 6645978
    Abstract: Ophthalmic compositions containing Lipoxin A4 and its analogs and methods of their use for treating dry eve are disclosed.
    Type: Grant
    Filed: March 23, 2001
    Date of Patent: November 11, 2003
    Assignee: Alcon, Inc.
    Inventors: Daniel A. Gamache, Gustav Graff, Mark R. Hellberg, Peter G. Klimko, John M. Yanni
  • Method of treating dry eye disorders
    Patent number: 6645994
    Abstract: Inhibitors of acyl-CoA synthetase are useful for treating dry eye disorders and other disorders requiring the wetting of the eye.
    Type: Grant
    Filed: May 21, 2002
    Date of Patent: November 11, 2003
    Assignee: Alcon, Inc.
    Inventor: Daniel A. Gamache
  • Method of treating vascular endothelial growth factor mediated vascular disorders
    Publication number: 20030207941
    Abstract: The use of amfenac and derivatives, including nepafenac, to treat vascular endothelial growth factor mediated vascular disorders.
    Type: Application
    Filed: April 16, 2003
    Publication date: November 6, 2003
    Inventors: David P. Bingaman, Michael A. Kapin, Daniel A. Gamache, Gustav Graff, John M. Yanni
  • Method of treating neurodegenerative disorders of the retina and optic nerve head
    Patent number: 6638976
    Abstract: The use of 3-benzolphenylacetic acids and derivatives, including nepafenac, to treat neurodegenerative retinal disorders is disclosed.
    Type: Grant
    Filed: August 13, 2001
    Date of Patent: October 28, 2003
    Assignee: Alcon, Inc.
    Inventors: Daniel A. Gamache, Gustav Graff, John M. Yanni, Michael A. Kapin
  • Method of treating angiogenesis-related disorders
    Publication number: 20030187072
    Abstract: The use of 3-benzolphenylacetic acids and derivatives, including nepafenac, to treat angiogenesis-related disorders, including ophthalmic angiogenesis-related disorders such as diabetic retinopathy and exudative macular degeneration, is disclosed.
    Type: Application
    Filed: February 14, 2003
    Publication date: October 2, 2003
    Inventors: Michael A. Kapin, David P. Bingaman, Daniel A. Gamache, Gustav Graff, John M. Yanni
  • Methods for treating dry eye
    Publication number: 20030109508
    Abstract: Methods of treating dry eye by administering fixed combinations of MUC-1 secretagogues, such as HETE derivatives, and androgen compounds are disclosed.
    Type: Application
    Filed: September 26, 2002
    Publication date: June 12, 2003
    Applicant: Alcon, Inc.
    Inventors: John M. Yanni, Daniel A. Gamache
  • Methods for treating dry eye
    Publication number: 20030109509
    Abstract: Methods of treating dry eye by administering fixed combinations of MUC-1 secretagogues, such as HETE derivatives, and anti-inflammatory steroids are disclosed.
    Type: Application
    Filed: September 26, 2002
    Publication date: June 12, 2003
    Applicant: Alcon, Inc.
    Inventors: Daniel A. Gamache, John M. Yanni, Barry F. Van Duzee
  • Methods for treating dry eye
    Publication number: 20030109488
    Abstract: Methods of treating dry eye by administering fixed combinations of MUC-1 secretagogues, such as HETE derivatives, and lacrimal gland stimulants are disclosed.
    Type: Application
    Filed: September 26, 2002
    Publication date: June 12, 2003
    Applicant: Alcon, Inc.
    Inventors: John M. Yanni, Daniel A. Gamache