Abstract: Disclosed herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, that are inhibitors of Polo Like Kinase 4 (PLK4). Also disclosed herein are pharmaceutical compositions comprising the compounds of Formula (I), or pharmaceutically acceptable salts thereof, and one or more pharmaceutically acceptable excipients. Further disclosed herein are methods of treating cancer in a subject in need thereof, comprising administering to the subject an amount of a compound of Formula (I), or a pharmaceutically acceptable salt thereof.

Abstract: An atherectomy system includes a handle having a handle housing, with a drive member extending through the handle housing and operably coupled to an atherectomy burr. A drive mechanism is disposed within the handle housing and is adapted to rotatably engage the drive member. The drive mechanism may include an electric drive motor, a drive gear that is rotatably engaged with the electric drive motor and a driven gear that is coupled with the drive member and is engaged with the drive gear such that rotation of the driven gear causes rotation of the drive member. The drive mechanism may be configured to enable a rotation speed of the atherectomy burr of up to at least about 200,000 revolutions per minute (rpm).

Abstract: An atherectomy system includes a handle and a drive motor that is adapted to rotate a drive cable extending through the handle and operably coupled to an atherectomy burr. A control system is adapted to regulate operation of the drive motor, including providing the drive motor with a high frequency pulse width modulation (PWM) drive signal in order to operate the drive motor. The control system monitors a motor performance parameter such as motor speed or motor torque, and when the motor performance parameter approaches a limit of a performance range, the control system adds a low frequency PWM signal to the high frequency PWM drive signal, thereby causing the drive motor to produce a tactile signal that signals to the user that the motor performance parameter is approaching the limit of the performance range.

Abstract: Configurable filters for asymmetrical radio frequency communication are disclosed. In one aspect, a radio frequency module includes a first filter configured to band-pass frequencies for a first transmit sub-band of a first communication band, a second filter configured to band-pass frequencies for a second transmit sub-band of the first communication band, and a third filter configured to band-pass frequencies for a receive band of the first communication band. The radio frequency module further includes an antenna terminal and at least one antenna switch module configured to connect the third filter and one of the first and second filters to the antenna terminal.

Abstract: A cavitation nozzle is disclosed, including a plate, a hollow body, and a cap removably engaged with the hollow body and holding the plate against a distal end of the hollow body. The plate may have a central aperture and a distal surface, wherein the distal surface is bisected by a groove and the hollow body is configured to deliver high pressure fluid through the central aperture. The delivered high pressure fluid may be discharged as a cavitating jet.

Abstract: Disclosed herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, that are inhibitors of Polo Like Kinase 4 (PLK4). Also disclosed herein are pharmaceutical compositions comprising the compounds of Formula (I), or pharmaceutically acceptable salts thereof, and one or more pharmaceutically acceptable excipients. Further disclosed herein are methods of treating cancer in a subject in need thereof, comprising administering to the subject an amount of a compound of Formula (I), or a pharmaceutically acceptable salt thereof.

Abstract: Disclosed herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, that are inhibitors of Polo Like Kinase 4 (PLK4). Also disclosed herein are pharmaceutical compositions comprising the compounds of Formula (I), or pharmaceutically acceptable salts thereof, and one or more pharmaceutically acceptable excipients. Further disclosed herein are methods of treating cancer in a subject in need thereof, comprising administering to the subject an amount of a compound of Formula (I), or a pharmaceutically acceptable salt thereof.

Abstract: A method of cavitation peening may include coupling a moveable water source to a portable nozzle, through a flexible conduit. The method may include positioning the nozzle adjacent a treatment surface and discharging a first and second stream of fluid through a first and second channel of the nozzle, with the second channel concentrically positioned around the first channel. The first stream may have a first pressure, and the second stream may have a second pressure, the first pressure being greater than the second pressure and the two streams combining to generate a cloud of cavitation bubbles.

Abstract: An apparatus for treating a surface of an object is disclosed, including a carrier configured to transport the object through a treatment zone and an array of nozzle devices, each nozzle device positioned to deliver a cavitating jet into the treatment zone. The apparatus further includes a fluid source, a pump connected to the fluid source, and a hose configured to carry fluid under high pressure generated by the pump from the fluid source to the array of nozzle devices.

Abstract: A cavitation peening system is disclosed, including a tank containing a fluid, a carrier, and an array of cavitation nozzles. The carrier is configured to deliver a workpiece to a treatment zone in the tank, and the array of cavitation nozzles are collectively configured to generate a cavitation induced whirlpool in the treatment zone.

Abstract: A method of smoothing an inner surface of a tubular wall of a workpiece is disclosed, including immersing the workpiece in a mixture of a liquid and an abrasive and inserting a cavitation peening nozzle into a cavity of the workpiece. The method further includes injecting a cavitating jet from the cavitation peening nozzle into the cavity.

Abstract: Disclosed herein is a method of facilitating conducting a competition between participants, in accordance with some embodiments.

Abstract: A hot-forming press (100) comprises a lower press assembly (102) and an upper press assembly (108). The lower press assembly (102) is movable along a vertical axis and comprises a lower die (106), and a lower hot-box portion (104), configured to receive the lower die (106). The upper press assembly (108) is movable along the vertical axis above the lower press assembly (102) and comprises an upper die (112), and an upper hot-box portion (110). The upper hot-box portion (110) is configured to receive the upper die (112) so that the upper die (112) is positioned opposite the lower die (106). The lower die (106) and the upper die (112) are configured to apply a forming pressure to a workpiece (114) that is received between the lower die (106) and the upper die (112). The lower hot-box portion (104) and the upper hot-box portion (110) are configured to heat the workpiece (114).

Abstract: Crack-free powder-based, near net shaped parts are fabricated using a die assembly and cold isostatic pressing. Soft materials are introduced on both sides of die components in order to balance compression loads applied to the die component, and thereby avoid deformation of the die component.

Abstract: An apparatus for cavitation peening is disclosed, including a fluid source, a conduit, and a portable nozzle assembly. The conduit includes a proximal end portion connected to the fluid source and a distal end portion connected to the portable nozzle assembly. The portable nozzle assembly includes an inner nozzle configured to channel a first stream of high-pressure fluid, and an outer nozzle configured to channel a second stream of low-pressure fluid concentrically around the first stream. The inner nozzle includes a cavitation insert having an inner passage with at least two reductions in cross-sectional area.

Abstract: Information and passive biometric capture systems and methods. The information system includes a housing having a cavity configured to receive tangible items therein. A transparent, touch-sensitive display device is positioned over the cavity and configured such that in response to pixels of the display being black, the tangible items behind the black pixels are visible through the transparent display. A controller is programmed to receive from a remote server an alarm signal, and in response thereto, cause the display to change its state to indicate an alarm condition on the display. In response to receiving an input from the touch-sensitive display, a keypad is displayed, and inputs thereon are communicated to the remote server. The display can also display personal photographs stored in the memory device.

Abstract: Disclosed herein is a method of facilitating conducting a competition between participants, in accordance with some embodiments.

Abstract: The present invention relates to encapsulated active compounds (actives/active ingredients/AI) produced by different methods with minimized/eliminated negative effects on the plant/enhanced biological compatibility while efficacy against pests is maintained.

Abstract: A dental matrix system enabling back-to-back tooth cavity fillings to be less tedious and more efficient. A wedge attached to a matrix band that is designed to be inserted between two teeth and then expanded into position on opposing sides of a tooth so a ring can be placed. The device is inserted perpendicular to the biting/occlusal surface of the tooth or teeth identified for repair. The folded/bonded band is dropped down between the teeth. The matrix consisting of the matrix band and the end tail section of the wedge is pushed between the teeth. The bond between the two halves of matrix band is broken. The matrix band is folded into an open position. A ring is then placed over the device with the tips of the ring aligned inside the open geometry of the folded matrix band or outside of the matrix band after being folded in.

Abstract: A hot box comprises a lower hot-box portion and an upper hot-box portion. The lower hot-box portion comprises a lower housing, a lower heating plate, and a lower insulation layer. The lower heating plate is received within the lower housing and is configured to support a lower die. The lower insulation layer is positioned between the lower housing and the lower heating plate. The upper hot-box portion is positionable above the lower hot-box portion and comprises an upper housing, an upper heating plate, and an upper insulation layer. The upper heating plate is received within the upper housing and is configured to support an upper die. The upper insulation layer is positioned between the upper housing and the upper heating plate.