Abstract: The invention provides devices, systems and methods for tissue approximation and repair at treatment sites. The devices, systems and methods of the invention will find use in a variety of therapeutic procedures, including endovascular, minimally-invasive, and open surgical procedures, and can be used in various anatomical regions, including the abdomen, thorax, cardiovascular system, heart, intestinal tract, stomach, urinary tract, bladder, lung, and other organs, vessels, and tissues. The invention is particularly useful in those procedures requiring minimally-invasive or endovascular access to remote tissue locations, where the instruments utilized must negotiate long, narrow, and tortuous pathways to the treatment site. In addition, many of the devices and systems of the invention are adapted to be reversible and removable from the patient at any point without interference with or trauma to internal tissues.

Abstract: The invention provides devices, systems and methods for tissue approximation and repair at treatment sites. The devices, systems and methods of the invention will find use in a variety of therapeutic procedures, including endovascular, minimally-invasive, and open surgical procedures, and can be used in various anatomical regions, including the abdomen, thorax, cardiovascular system, heart, intestinal tract, stomach, urinary tract, bladder, lung, and other organs, vessels, and tissues. The invention is particularly useful in those procedures requiring minimally-invasive or endovascular access to remote tissue locations, where the instruments utilized must negotiate long, narrow, and tortuous pathways to the treatment site. In addition, many of the devices and systems of the invention are adapted to be reversible and removable from the patient at any point without interference with or trauma to internal tissues.

Abstract: This disclosure relates to methods of treating interstitial lung disease by administering Compound A to the subject at one or more daily dosages lower than the standard daily dosage during a dose titration period of treatment then increasing the dosage to the standard daily dosage of Compound A, wherein the standard daily dosage is about 240 mg/day of Compound A, or an equivalent amount of a pharmaceutically acceptable salt thereof.

Abstract: This disclosure relates to methods of treating interstitial lung disease by administering an LPA1 antagonist to the subject at one or more daily dosages lower than the standard daily dosage during a dose titration period of treatment then increasing the dosage to the standard daily dosage of the LPA1 antagonist.

Abstract: An adjustable length strut includes two joints, a threaded rod extending between the joints, and a tube adapted to receive the threaded rod. An actuation mechanism with gear teeth extending radially outward of the strut axis is rotatably fixed to the threaded rod. A protrusion may be coupled to an end of the threaded rod by a rotatable collar, with the protrusion extending through a slot in the tube to mark the length of the strut. A modular attachment member may be adapted to be couple to the first joint and include a worm gear adapted to engage gear teeth of the actuation mechanism. The modular attachment member may include a radiofrequency identity tag mechanism adapted to be read by a tag reader of a tool, the tool adapted to couple to the attachment member to rotate the worm gear to increase or decrease the effective length of the strut.

Abstract: An adjustable length strut includes two joints, a threaded rod extending between the joints, and a tube adapted to receive the threaded rod. An actuation mechanism with gear teeth extending radially outward of the strut axis is rotatably fixed to the threaded rod. A protrusion may be coupled to an end of the threaded rod by a rotatable collar, with the protrusion extending through a slot in the tube to mark the length of the strut. A modular attachment member may be adapted to be couple to the first joint and include a worm gear adapted to engage gear teeth of the actuation mechanism. The modular attachment member may include a radiofrequency identity tag mechanism adapted to be read by a tag reader of a tool, the tool adapted to couple to the attachment member to rotate the worm gear to increase or decrease the effective length of the strut.

Abstract: The invention is a system that enables passive sonar identification of underwater items by making use of lift bags and/or flags, having distinctive sequences of bands of sonar-signal-reflecting materials, wherein the lift items are partially inflated so as to present a predictable orientation with respect to the floor of a body of water and its surface.

Abstract: Keyboards, input devices, and related systems include key mechanisms with keycaps and actuators that provide adjustable feedback in response to user input. The actuators are controllable to provide variable tactile force or audible feedback that is dependent upon the user input. Encoders are able to transduce a location or relative position of a keycap as it is being pressed over time, and a signal is provided to actuators to cause them to provide feedback corresponding to the position of the keycap as it moves. The feedback can change the feel or sound of the keycap based on the keycap positions, time of operation, velocity, user identity, and other factors. Thus, the feel or sound of a keyboard or related input device can be adjusted electronically for efficient testing and increased user customization and feedback modes.

Abstract: A powered ride-on vehicle having a frame supported by a first drive wheel, a second drive wheel and at least one non-driven support wheel. The vehicle has a first motor connected to the first drive wheel, a second motor connected to the second drive wheel, a steering wheel, a plurality of movement selectors, a dance selector, and one or more controllers operably electrically connected to the motors, the plurality of movement selectors, and the dance selector. The controllers operate to manipulate the motors to cause movements of the vehicle for a set period of time upon depression of one of the plurality of movement selectors independent of an angular location of the steering wheel. The controllers further operate to manipulate the motors to cycle through at least four different dances based on subsequent depression of the dance selector.

Abstract: Robotic system and methods for robotic arthroplasty are provided. The robotic system includes a machining system and a guidance system. The guidance station tracks movement of one or more of various objects in the operating room, such as a surgical tool, a tibia of a patient, a talus of the patient, or a component of an implant. The guidance system tracks these objects for purposes of displaying their relative positions and orientations to the surgeon and, in some cases, for purposes of controlling movement of the surgical tool of the machining system relative to virtual cutting boundaries or other virtual objects associated with the tibia and talus to facilitate preparation of bone to receive an ankle implant system.

Abstract: Robotic system and methods for robotic arthroplasty are provided. The robotic system includes a machining system and a guidance system. The guidance station tracks movement of one or more of various objects in the operating room, such as a surgical tool, a tibia of a patient, a talus of the patient, or a component of an implant. The guidance system tracks these objects for purposes of displaying their relative positions and orientations to the surgeon and, in some cases, for purposes of controlling movement of the surgical tool of the machining system relative to virtual cutting boundaries or other virtual objects associated with the tibia and talus to facilitate preparation of bone to receive an ankle implant system.

Abstract: An adjustable length strut includes two joints, a threaded rod extending between the joints, and a tube adapted to receive the threaded rod. An actuation mechanism with gear teeth extending radially outward of the strut axis is rotatably fixed to the threaded rod. A protrusion may be coupled to an end of the threaded rod by a rotatable collar, with the protrusion extending through a slot in the tube to mark the length of the strut. A modular attachment member may be adapted to be couple to the first joint and include a worm gear adapted to engage gear teeth of the actuation mechanism. The modular attachment member may include a radiofrequency identity tag mechanism adapted to be read by a tag reader of a tool, the tool adapted to couple to the attachment member to rotate the worm gear to increase or decrease the effective length of the strut.

Abstract: An adjustable length strut includes two joints, a threaded rod extending between the joints, and a tube adapted to receive the threaded rod. An actuation mechanism with gear teeth extending radially outward of the strut axis is rotatably fixed to the threaded rod. A protrusion may be coupled to an end of the threaded rod by a rotatable collar, with the protrusion extending through a slot in the tube to mark the length of the strut. A modular attachment member may be adapted to be couple to the first joint and include a worm gear adapted to engage gear teeth of the actuation mechanism. The modular attachment member may include a radiofrequency identity tag mechanism adapted to be read by a tag reader of a tool, the tool adapted to couple to the attachment member to rotate the worm gear to increase or decrease the effective length of the strut.

Abstract: An interactive electronic trampoline assembly is made up of a frame, legs, a trampoline mat, a plurality of bias members to secure the trampoline mat to the frame, and a sensor to sense movement of the trampoline mat. A handlebar may also be connected to the frame. A control module may be removably secured to the assembly adjacent the frame. The control module may have a speaker, a power source, a controller, lights and control buttons. The sensor may also be housed in the control module. Different lights and sounds are output based on an input to the controller, the game being played and input received by the sensor.

Abstract: The invention is a system that enables passive sonar identification of underwater items by making use of lift bags and/or flags, having distinctive sequences of bands of sonar-signal-reflecting materials, wherein the lift items are partially inflated so as to present a predictable orientation with respect to the floor of a body of water and its surface.

Abstract: Keyboards, input devices, and related systems include key mechanisms with keycaps and actuators that provide adjustable feedback in response to user input. The actuators are controllable to provide variable tactile force or audible feedback that is dependent upon the user input. Encoders are able to transduce a location or relative position of a keycap as it is being pressed over time, and a signal is provided to actuators to cause them to provide feedback corresponding to the position of the keycap as it moves. The feedback can change the feel or sound of the keycap based on the keycap positions, time of operation, velocity, user identity, and other factors. Thus, the feel or sound of a keyboard or related input device can be adjusted electronically for efficient testing and increased user customization and feedback modes.

Abstract: Keyboards, input devices, and related systems include key mechanisms with keycaps and actuators that provide adjustable feedback in response to user input. The actuators are controllable to provide variable tactile force or audible feedback that is dependent upon the user input. Encoders are able to transduce a location or relative position of a keycap as it is being pressed over time, and a signal is provided to actuators to cause them to provide feedback corresponding to the position of the keycap as it moves. The feedback can change the feel or sound of the keycap based on the keycap positions, time of operation, velocity, user identity, and other factors. Thus, the feel or sound of a keyboard or related input device can be adjusted electronically for efficient testing and increased user customization and feedback modes.

Abstract: An external fixation frame system may include a first ring, a second ring, and at least three struts configured to couple the first ring to the second ring, each strut having a rotatable head portion and a counter torque portion. The system may also include an adjustment tool that includes a driver portion having an inner engagement portion for engaging the head portion of the strut, an outer engagement portion for engaging the counter torque portion of the strut, and a feedback mechanism rotatably coupled to the inner and outer engagement portions. The tool may further include a plunger having an inner portion positioned at least partially within the inner engagement portion, and an outer portion positioned at least partially between the inner engagement portion and the outer engagement portions, the plunger being axially translatable with respect to the inner and outer engagement portions.

Abstract: The invention is a system that enables passive sonar identification of underwater items by making use of lift bags and/or flags, having distinctive sequences of bands of sonar-signal-reflecting materials, wherein the lift items are partially inflated so as to present a predictable orientation with respect to the floor of a body of water and its surface.

Abstract: A powered ride-on vehicle having a frame supported by a first drive wheel, a second drive wheel and at least one non-driven support wheel. The vehicle has a first motor connected to the first drive wheel, a second motor connected to the second drive wheel, a steering wheel, a plurality of movement selectors, a dance selector, and one or more controllers operably electrically connected to the motors, the plurality of movement selectors, and the dance selector. The controllers operate to manipulate the motors to cause movements of the vehicle for a set period of time upon depression of one of the plurality of movement selectors independent of an angular location of the steering wheel. The controllers further operate to manipulate the motors to cycle through at least four different dances based on subsequent depression of the dance selector.